EP0321231B1 - Compositions pharmaceutiques - Google Patents
Compositions pharmaceutiques Download PDFInfo
- Publication number
- EP0321231B1 EP0321231B1 EP88311861A EP88311861A EP0321231B1 EP 0321231 B1 EP0321231 B1 EP 0321231B1 EP 88311861 A EP88311861 A EP 88311861A EP 88311861 A EP88311861 A EP 88311861A EP 0321231 B1 EP0321231 B1 EP 0321231B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- phenol
- dyclonine
- dyclonine hcl
- antimicrobial
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Definitions
- This invention is directed to pharmaceutical compositions containing dyclonine hydrochloride (HCl) and phenol.
- Dyclonine HCl chemically denoted as 3-piperidino-4′-butoxypropiophenone hydrochloride, is a well known anesthetic/analgesic agent for topical use on the mucous membranes of the mouth and throat (see Federal Register, Vol. 47, No. 101, Proposed Rules, pages 22810-13, 1982).
- compositions of dyclonine HCl commercially available in the United States include and aqueous liquid spray containing 0.1% dyclonine HCl and solid lozenges containing 1.2 mg dyclonine HCl per lozenge for children and 3.0 mg per lozenge for adults (see Physicians' Desk Reference for Non-prescription Drugs, 8th Ed., 1987, pages 518-9).
- the benefit of dyclonine HCl is that it provides long acting topical anesthetic relief.
- the use of certain acids, particularly citric acid, to stabilize dyclonine HCl in anesthetic lozenges is reported in US-A-4,139,627.
- dyclonine HCl is known to possess antimicrobial activity.
- US-A-2,868,689 discloses stabilized aqueous preparations of dyclonine HCl (0.1-58) having topical anesthetic and antimicrobial action, the stabilization aspect being provided by the addition of chlorobutanol (0.1-0.5%).
- Phenol is a known topical anesthetic, which has been used to treat minor sore mouth and sore throat pain.
- the mode of action, fast acting but not long lasting, is that it desensitizes sensory nerve receptors present in the mucous membranes of the throat and oral cavity to exert its local anestheticeffect.
- Previous dosage forms of administration have included lozenges containing 32.5 mg phenol per lozenge and aqueous solutions of 1.4% phenol for use as a mouthwash, rinse or gargle, which is expelled from the oral cavity after use, and as a throat spray (see Physicians' Desk Reference for Non-prescription Drugs, 8th Ed., 1987, pages 654-5).
- phenol is known to possess antimicrobial activity.
- a liquid pharmaceutical composition of matter for oral health care use arid having enhanced antimicrobial action comprising an aqueous-based orally acceptable pharmaceutical carrier having incorporated therein from 0.05 to 2.0 w/v percent of dyclonine hydrochloride and from 1.0 to 1.4 w/v percent of phenol, said composition having a pH of from 3 to 4.
- the subject invention provides a pharmaceutical composition of matter for oral health care use which not only provides relief of pain in irritated mucous membranes of the mouth and throat, but also provides enhanced antimicrobial activity.
- oral includes the throat and oral cavity with contiguous mucosal tissues. Accordingly, the composition of this invention has beneficial application in treating, for example, sore or bacteria infected throat, cough-irritated sore throat, and other oral ailments wherein the source of irritation is partly or wholly derived from microbial infection.
- composition of this invention possesses antimicrobial action that is greater than the sum of that possessed by dyclonine HCl or phenol when used alone.
- the enhanced antimicrobial action between dyclonine HCl and phenol is demonstrated in the following type experiment using Staphylococcus aureus, a gram-positive bacterium.
- test formulation A five millimeter (ml) aliquot of the test formulation is dispensed into a clean 18 mm borosilicate glass test tube for the undiluted sample. Dilutions of the test formulation are prepared using sterile deionized water.
- the inoculum suspension is prepared from an overnight growth of the challenge organism on appropriate media.
- SCDA Soybean Casein Digest Agar
- SCDA contains 15 grams/liter (g/L) Soybean Casein Digest Broth and 15 g/L agar.
- One liter of the medium is autoclaved at 15 psi and 121 C for 30-40 minutes and approximately 25 ml per plate are poured into sterile disposable 100 x 15 mm polystyrene Petri dishes.
- Surface growth from the overnight culture is transferred from the plate using a sterile wire loop to 6 ml of 0.85% sterile saline in a test tube.
- the suspension is adjusted to an optical density at 540 nanometers (OD540) of 0.5 as read in a Spectronic 20 spectrophotometer.
- OD540 optical density at 540 nanometers
- This OD540 is equivalent to approximately 5 x 108 colony forming units (cfu)/ml for S. aureus .
- the inoculum size is confirmed by serial dilution of the inoculum into Letheen broth and by plating dilutions onto SCDA using a spread plate technique.
- the enhanced antimicrobial effect of phenol and dyclonine HCl in aqueous pharmaceutical preparations is illustrated in Table I by the indicated test results obtained in accordance with the Methodology.
- the "Base Vehicle” and other test products are described hereinafter in Example 1.
- ATCC American Tissue Culture Collection
- the actual OD540 reading was 0.43 and the actual inoculum size was 5.7 x 106 cfu/ml.
- the symbol "P” represents phenol, and the symbol “D” represents dyclonine hydrochloride.
- the numerical symbols indicate the recorded cfu/ml at the indicated time interval as follows:
- Test product containing 1.4% phenol shows complete kill by 30 seconds at full strength concentration and a two-fold dilution (1/2x). However, a four-fold dilution (1/4x) shows less antimicrobial effectiveness with a count of 10-100 cfu/ml being recorded even after 5 minutes.
- Test product containing 0.1% dyclonine HCl shows some activity at full strength with complete kill by 3 minutes. However, no activity is recorded at either two-fold or four-fold dilutions.
- Test product with both 1.4% phenol and 0.1% dyclonine HCl shows complete kill by 30 seconds at full strength, two-fold dilution and four-fold dilution. At the four-fold dilution, the combination product has a faster onset of action than either of the single entity products.
- the test results demonstrate that the two actives together have more than an additive effect on the antimicrobial activity of the formulations.
- Test product containing both 1.0% phenol and 0.1% dyclonine HCL shows a similar effect. With 1.0% phenol alone, diluted four-fold, a 1001-10,000 cfu/ml count is observed after 5 minutes; and the four-fold dilution of dyclonine HCl alone shows no effect. In contrast, the four-fold dilution of the combination of the two actives shows complete kill by 5 minutes.
- the present invention thus provides a novel pharmaceutical composition of matter for oral health care use, wherein it is sought to elicit an antimicrobial response.
- the combination of the two actives provides the benefit of both faster acting topical anesthetic activity attributable to the phenol and longer acting topical anesthetic activity attributable to the dyclonine HCl, particularly for the relief of sore throat or mouth conditions requiring antimicrobial treatment.
- Said composition comprises the two essential active ingredients, dyclonine hydrochloride and phenol, in admixture with a pharmaceutically acceptable carrier.
- the dyclonine HCl and phenol are incorporated into a liquid pharmaceutically acceptable carrier according to conventional pharmaceutical practices.
- the carrier is an aqueous-based pharmaceutically acceptable carrier, that is, one wherein the entire or predominant solvent content is water.
- aqueous-based pharmaceutically acceptable carrier that is, one wherein the entire or predominant solvent content is water.
- the pH of the subject compositions utilizing an aqueous-based orally acceptable pharmaceutical carrier is from 3 to 4 and, preferably, from 3.2 to 3.6.
- acid buffers consistent with conventional pharmaceutical practices are generally utilized such as, for example, citrate and phosphate buffers.
- stabilized aqueous pharmaceutical compositions containing dyclonine HCl are heretofore known as, for example, in US-A-2,868,689. Accordingly, in a stable liquid pharmaceutiral composition for oral health care use comprising an aqueous-based orally acceptable pharmaceutical carrier having incorporated therein an effective topical anesthetic and antimicrobial amount of dyclonine HCl, the present invention provides the improvement comprising the incorporation therein of the herein mentioned amounts of phenol.
- liquid preparations for oral health care purposes it is common practice to include such product enhancing optional additives as colorants, flavorants and co-solvents, which additives may affect the total solubility of the two actives in the final product.
- a liquid composition of this invention having an aqueous-based orally acceptable pharmaceutical carrier has from 0.05 to 2.0 weight/volume (w/v) percent of dyclonine HCl and from 1.0 to 1.4 w/v percent of phenol incorporated into said carrier.
- compositions of this invention may optionally contain one or more other known therapeutic agents, particularly those commonly utilized in oral health care preparations, such as, for example, other agents having local anesthetic or antimicrobial activity.
- Other optional ingredients which are non-therapeutic and well known to the pharmacist's art may also be included in amounts generally known for such ingredients, for example, natural or artificial sweeteners, flavoring agents and colorants to provide a palatable and pleasant looking final product; ethyl alcohol, propylene glycol and glycerin as co-solvents; and other typical pharmaceutically acceptable ingredients commonly employed in compositions of this type.
- the foregoing formulation represents the herein mentioned Base Vehicle, which is an aqueous-based orally acceptable pharmaceutical carrier without either the dyclonine HCl or the phenol.
- Base Vehicle an aqueous-based orally acceptable pharmaceutical carrier without either the dyclonine HCl or the phenol.
- P phenol
- D dyclonine HCl
- both phenol and dyclonine HCl are added to the Base Vehicle in the indicated percentages to provide the herein mentioned two respective test products with both P and D as combined actives, i.e., two respective embodiments of the compositions of this invention.
- the antimicrobial effectiveness of combined phenol and dyclonine HCl on the yeast microorganism, Candida albicans is demonstrated in Table II, the indicated test results being obtained in accordance with the previously described Methodology with the following modifications.
- the OD540 of 0.5 is approximately equivalent to 5 x 107 cfu/ml for C. albicans .
- the actual OD540 was 0.63 and the actual inoculum size was 1.8 x 105.
- the particular microorganism is C. albicans ATCC 10231. Other indicated symbols are as previously denoted.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT88311861T ATE73329T1 (de) | 1987-12-16 | 1988-12-15 | Pharmazeutische zusammensetzungen. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/133,834 US4808410A (en) | 1987-12-16 | 1987-12-16 | Pharmaceutical compositions containing dyclonine HC1 and phenol |
US133834 | 1987-12-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0321231A1 EP0321231A1 (fr) | 1989-06-21 |
EP0321231B1 true EP0321231B1 (fr) | 1992-03-11 |
Family
ID=22460497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP88311861A Expired - Lifetime EP0321231B1 (fr) | 1987-12-16 | 1988-12-15 | Compositions pharmaceutiques |
Country Status (11)
Country | Link |
---|---|
US (1) | US4808410A (fr) |
EP (1) | EP0321231B1 (fr) |
JP (1) | JPH01265026A (fr) |
KR (1) | KR890009400A (fr) |
AT (1) | ATE73329T1 (fr) |
AU (1) | AU629803B2 (fr) |
CA (1) | CA1318599C (fr) |
DE (1) | DE3869088D1 (fr) |
DK (1) | DK701188A (fr) |
NZ (1) | NZ227339A (fr) |
PH (1) | PH24860A (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4892877A (en) * | 1987-10-27 | 1990-01-09 | Richardson-Vicks Inc. | Antitussive liquid compositions containing phenol |
US4917894A (en) * | 1988-06-29 | 1990-04-17 | Beecham Inc. | Rapid-onset long-duration oral anesthetic composition |
ZA90341B (en) * | 1989-01-23 | 1990-10-31 | Merrell Dow Pharma | Liquid pharmaceutical composition for piperidinoalkanol derivatives |
US4931473A (en) * | 1989-02-15 | 1990-06-05 | Richardson-Vicks Inc. | Anesthetic oral compositions |
US5100898A (en) * | 1990-01-25 | 1992-03-31 | Richardson-Vicks Inc. | Antitussive liquid compositions containing dyclonine |
US5478565A (en) * | 1990-03-27 | 1995-12-26 | Warner-Lambert Company | Treatment of sinus headache |
US5547657A (en) * | 1994-10-11 | 1996-08-20 | Eastman Chemical Company | Low-irritation anesthetic and antiseptic mouth rinse |
US5641512A (en) * | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
US10179159B2 (en) | 1999-10-22 | 2019-01-15 | Scott Wepfer | Topical anesthetic formulation |
AU5286901A (en) | 1999-10-22 | 2001-06-18 | Transdermatech, Inc. | Topical anesthetic formulation |
US7144846B2 (en) * | 2004-05-11 | 2006-12-05 | Steris, Inc. | Acidic phenolic disinfectant compositions |
PL2552440T3 (pl) * | 2010-03-30 | 2019-04-30 | Helperby Therapeutics Ltd | Nowa kombinacja i zastosowanie |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2868689A (en) * | 1956-10-09 | 1959-01-13 | Allied Lab Inc | Pharmaceutical preparations containing dyclonine hydrochloride and chlorobutanol |
US3203097A (en) * | 1963-04-25 | 1965-08-31 | Denver Chemical Mfg Company | Germicidal dental pad |
US4067997A (en) * | 1975-05-21 | 1978-01-10 | Med-Chem Laboratories | Synergistic microbecidal composition and method |
US4139627A (en) * | 1977-10-06 | 1979-02-13 | Beecham Inc. | Anesthetic lozenges |
DE2860482D1 (en) * | 1977-11-07 | 1981-03-26 | Beecham Inc | Anaesthetic lozenges and method of preparing them |
JPS5549317A (en) * | 1978-10-02 | 1980-04-09 | Dow Chemical Co | Control of virus surrounded with phenylketones |
US4624849A (en) * | 1984-11-02 | 1986-11-25 | The Procter & Gamble Company | Antimicrobial lozenges |
US4713243A (en) * | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
-
1987
- 1987-12-16 US US07/133,834 patent/US4808410A/en not_active Expired - Fee Related
-
1988
- 1988-12-13 PH PH37915A patent/PH24860A/en unknown
- 1988-12-14 CA CA000585914A patent/CA1318599C/fr not_active Expired - Fee Related
- 1988-12-14 KR KR1019880016639A patent/KR890009400A/ko not_active Application Discontinuation
- 1988-12-15 EP EP88311861A patent/EP0321231B1/fr not_active Expired - Lifetime
- 1988-12-15 DE DE8888311861T patent/DE3869088D1/de not_active Expired - Fee Related
- 1988-12-15 NZ NZ227339A patent/NZ227339A/xx unknown
- 1988-12-15 AT AT88311861T patent/ATE73329T1/de not_active IP Right Cessation
- 1988-12-16 AU AU27004/88A patent/AU629803B2/en not_active Ceased
- 1988-12-16 JP JP63318318A patent/JPH01265026A/ja active Pending
- 1988-12-16 DK DK701188A patent/DK701188A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2700488A (en) | 1989-06-22 |
CA1318599C (fr) | 1993-06-01 |
AU629803B2 (en) | 1992-10-15 |
PH24860A (en) | 1990-12-26 |
US4808410A (en) | 1989-02-28 |
KR890009400A (ko) | 1989-08-01 |
DE3869088D1 (de) | 1992-04-16 |
EP0321231A1 (fr) | 1989-06-21 |
JPH01265026A (ja) | 1989-10-23 |
DK701188D0 (da) | 1988-12-16 |
ATE73329T1 (de) | 1992-03-15 |
DK701188A (da) | 1989-06-17 |
NZ227339A (en) | 1990-09-26 |
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