EP0309969A3 - Méthode de mise en carte de gènes - Google Patents

Méthode de mise en carte de gènes Download PDF

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Publication number
EP0309969A3
EP0309969A3 EP19880115842 EP88115842A EP0309969A3 EP 0309969 A3 EP0309969 A3 EP 0309969A3 EP 19880115842 EP19880115842 EP 19880115842 EP 88115842 A EP88115842 A EP 88115842A EP 0309969 A3 EP0309969 A3 EP 0309969A3
Authority
EP
European Patent Office
Prior art keywords
fragments
cleaved
labeling
fragment
derivatized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19880115842
Other languages
German (de)
English (en)
Other versions
EP0309969B1 (fr
EP0309969A2 (fr
Inventor
Kenneth James Livak
Sydney Brenner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PerkinElmer Health Sciences Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of EP0309969A2 publication Critical patent/EP0309969A2/fr
Publication of EP0309969A3 publication Critical patent/EP0309969A3/fr
Application granted granted Critical
Publication of EP0309969B1 publication Critical patent/EP0309969B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP88115842A 1987-09-28 1988-09-27 Méthode de mise en carte de gènes Expired - Lifetime EP0309969B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10310587A 1987-09-28 1987-09-28
US103105 1987-09-28
US185741 1988-04-25
US07/185,741 US5102785A (en) 1987-09-28 1988-04-25 Method of gene mapping

Publications (3)

Publication Number Publication Date
EP0309969A2 EP0309969A2 (fr) 1989-04-05
EP0309969A3 true EP0309969A3 (fr) 1991-03-06
EP0309969B1 EP0309969B1 (fr) 1995-07-19

Family

ID=26800094

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88115842A Expired - Lifetime EP0309969B1 (fr) 1987-09-28 1988-09-27 Méthode de mise en carte de gènes

Country Status (8)

Country Link
US (1) US5102785A (fr)
EP (1) EP0309969B1 (fr)
JP (1) JP2653684B2 (fr)
CA (1) CA1322942C (fr)
DE (1) DE3854176T2 (fr)
DK (1) DK536388A (fr)
GR (1) GR3017307T3 (fr)
IE (1) IE69577B1 (fr)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
FI95398C (fi) * 1989-06-24 1996-01-25 Boehringer Ingelheim Int Menetelmä ihmisen nuhaviruksen serotyypittämiseksi
FR2650840B1 (fr) * 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
AU8840091A (en) * 1990-08-24 1992-03-17 University Of Tennessee Research Corporation, The Dna amplification fingerprinting
US6074818A (en) * 1990-08-24 2000-06-13 The University Of Tennessee Research Corporation Fingerprinting of nucleic acids, products and methods
US5686065A (en) * 1991-03-27 1997-11-11 Special Advanced Biomaterials, Inc. Topical siloxane sunscreen compositions having enhanced performance and safety
DE4214112A1 (de) * 1991-08-02 1993-02-04 Europ Lab Molekularbiolog Neues verfahren zur sequenzierung von nukleinsaeuren
GB2264496B (en) * 1992-02-25 1995-10-25 Us Energy Sizing of fragments from a nucleic acid sequence
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
US5547859A (en) * 1993-08-02 1996-08-20 Goodman; Myron F. Chain-terminating nucleotides for DNA sequencing methods
GB9401200D0 (en) * 1994-01-21 1994-03-16 Medical Res Council Sequencing of nucleic acids
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5714330A (en) * 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5831065A (en) * 1994-04-04 1998-11-03 Lynx Therapeutics, Inc. Kits for DNA sequencing by stepwise ligation and cleavage
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5604100A (en) * 1995-07-19 1997-02-18 Perlin; Mark W. Method and system for sequencing genomes
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5780231A (en) * 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
WO1997029211A1 (fr) * 1996-02-09 1997-08-14 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services VISUALISATION PAR RESTRICTION (RD-PCR) DES ARNm EXPRIMES DE MANIERE DIFFERENTIELLE
CZ397998A3 (cs) * 1996-06-06 1999-07-14 Lynx Therapeutics, Inc. Způsob sekvenční analýzy ligací kódovaného adaptoru
GB9620769D0 (en) * 1996-10-04 1996-11-20 Brax Genomics Ltd Nucleic acid sequencing
US6258533B1 (en) * 1996-11-01 2001-07-10 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
ATE289358T1 (de) * 1997-06-27 2005-03-15 Lynx Therapeutics Inc Verfahren zur restriktionskarten-analyse von polynukleotiden
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6054276A (en) * 1998-02-23 2000-04-25 Macevicz; Stephen C. DNA restriction site mapping
US6136537A (en) * 1998-02-23 2000-10-24 Macevicz; Stephen C. Gene expression analysis
WO2001006009A1 (fr) * 1999-07-20 2001-01-25 Pioneer Hi-Bred International, Inc. Profilage de sites de restriction
US20030228611A1 (en) * 2002-05-01 2003-12-11 President And Fellows Of Harvard College Nucleic acid memory device
WO2005026686A2 (fr) * 2003-09-09 2005-03-24 Compass Genetics, Llc Plate-forme analytique multiplexee
ATE451478T1 (de) 2004-02-12 2009-12-15 Population Genetics Technologi Genetische analyse mittels sequenzspezifischem sortieren
US7407757B2 (en) * 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US20060211030A1 (en) * 2005-03-16 2006-09-21 Sydney Brenner Methods and compositions for assay readouts on multiple analytical platforms
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US9074244B2 (en) * 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
WO2012068405A2 (fr) * 2010-11-17 2012-05-24 Isis Pharmaceuticals, Inc. Modulation de l'expression de l'alpha synucléine
BR112019022159A2 (pt) 2017-07-28 2020-05-12 Wright Medical Technology, Inc. Sistema e método de osteotomia articular
TWI809004B (zh) 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
WO2019140231A1 (fr) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Oligonucléotides antisens ciblant l'alpha-synucléine et leurs utilisations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558262A1 (fr) * 1984-01-16 1985-07-19 California Inst Of Techn Procede et systeme pour l'analyse par electrophorese de fragments d'adn obtenus par sequencage
WO1986007387A1 (fr) * 1985-06-13 1986-12-18 Amgen Procede et kit d'execution d'essais d'hybridation d'acides nucleiques
US4661408A (en) * 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4849077A (en) * 1984-08-06 1989-07-18 Akademie Der Wissenschaften Der Ddr Process for solid phase-sequencing of nucleic acid fragments
JPS61278453A (ja) * 1985-06-05 1986-12-09 Morita Tokushu Kiko Kk 定置式車両傾動装置
US4855225A (en) * 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
CA1340806C (fr) * 1986-07-02 1999-11-02 James Merrill Prober Methode, systeme et reactifs pour le sequencage de l'adn

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558262A1 (fr) * 1984-01-16 1985-07-19 California Inst Of Techn Procede et systeme pour l'analyse par electrophorese de fragments d'adn obtenus par sequencage
WO1986007387A1 (fr) * 1985-06-13 1986-12-18 Amgen Procede et kit d'execution d'essais d'hybridation d'acides nucleiques
US4661408A (en) * 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 83, October 1986, pages 7821-7825; A. COULSON et al.: "Toward a physical map of the genome of the nematode Caenorhabditis elegans" *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 83, October 1986, pages 7826-7830; M.V. OLSON et al.: "Random-clone strategy for genomic restriction mapping in yeast" *
SCIENCE, vol. 238, October 1987, pages 336-341; J.M. PROBER et al.: "A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides" *

Also Published As

Publication number Publication date
US5102785A (en) 1992-04-07
JP2653684B2 (ja) 1997-09-17
EP0309969B1 (fr) 1995-07-19
DE3854176T2 (de) 1996-02-15
DK536388A (da) 1989-03-29
DK536388D0 (da) 1988-09-27
IE882920L (en) 1989-03-28
DE3854176D1 (de) 1995-08-24
IE69577B1 (en) 1996-10-02
CA1322942C (fr) 1993-10-12
EP0309969A2 (fr) 1989-04-05
JPH01137983A (ja) 1989-05-30
GR3017307T3 (en) 1995-12-31

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