EP0303172A3 - Oxyimino-céphalosporines - Google Patents

Oxyimino-céphalosporines Download PDF

Info

Publication number
EP0303172A3
EP0303172A3 EP19880112640 EP88112640A EP0303172A3 EP 0303172 A3 EP0303172 A3 EP 0303172A3 EP 19880112640 EP19880112640 EP 19880112640 EP 88112640 A EP88112640 A EP 88112640A EP 0303172 A3 EP0303172 A3 EP 0303172A3
Authority
EP
European Patent Office
Prior art keywords
lower alkyl
hydrogen
group
carbamoyl
cycloalkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19880112640
Other languages
German (de)
English (en)
Other versions
EP0303172A2 (fr
Inventor
Erwin Dr. Götschi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP0303172A2 publication Critical patent/EP0303172A2/fr
Publication of EP0303172A3 publication Critical patent/EP0303172A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP19880112640 1987-08-14 1988-08-03 Oxyimino-céphalosporines Withdrawn EP0303172A3 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH3133/87 1987-08-14
CH313387 1987-08-14
CH472687 1987-12-03
CH4726/87 1987-12-03

Publications (2)

Publication Number Publication Date
EP0303172A2 EP0303172A2 (fr) 1989-02-15
EP0303172A3 true EP0303172A3 (fr) 1991-05-15

Family

ID=25692275

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880112640 Withdrawn EP0303172A3 (fr) 1987-08-14 1988-08-03 Oxyimino-céphalosporines

Country Status (15)

Country Link
US (2) US5036064A (fr)
EP (1) EP0303172A3 (fr)
JP (1) JPS6466190A (fr)
KR (1) KR890003776A (fr)
AU (1) AU614984B2 (fr)
DK (1) DK455288A (fr)
FI (1) FI883766A (fr)
HU (1) HUT47944A (fr)
IL (1) IL87374A0 (fr)
MC (1) MC1970A1 (fr)
NO (1) NO883590L (fr)
NZ (1) NZ225754A (fr)
PH (1) PH25646A (fr)
PT (1) PT88274B (fr)
YU (1) YU156388A (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366189A3 (fr) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Lactames-quinolones antimicrobiennes
US5030724A (en) * 1990-01-22 1991-07-09 E. R. Squibb & Sons, Inc. Monobactam hydrazides containing catechol sulfonic acid groups
US20040197408A1 (en) * 2002-12-30 2004-10-07 Angiotech International Ag Amino acids in micelle preparation
US7537532B2 (en) * 2007-05-16 2009-05-26 Young Carl D Handle for implement and method
KR101719556B1 (ko) * 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
CA2848012A1 (fr) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Procedes de traitement d'infections intrapulmonaires
CN103958527A (zh) * 2011-10-04 2014-07-30 盐野义制药株式会社 具有儿茶酚基团的头孢烯衍生物
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
JP5681331B2 (ja) 2012-11-19 2015-03-04 三井化学株式会社 ポリエステル樹脂組成物とその製造方法
US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
MX2020004205A (es) 2013-03-15 2021-11-16 Merck Sharp & Dohme Llc Composiciones antibioticas de ceftolozano.
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
AU2014233637A1 (en) 2013-09-09 2015-03-26 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189287A2 (fr) * 1985-01-21 1986-07-30 Nippon Pharmaceutical Development Institute Company Limited Bêta-lactames antibiotiques
EP0254495A2 (fr) * 1986-07-21 1988-01-27 Sankei Pharmaceutical Company Limited Dérivés bêta-lactame, procédé pour leur préparation, compositions pharmaceutiques les contenant et intermédiaires

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
GB1596278A (en) * 1976-11-30 1981-08-26 Glaxo Operations Ltd 7-(-oxyimino-acetamino)cephalosporin derivatives
EP0150507B1 (fr) * 1983-12-29 1992-08-05 Mochida Pharmaceutical Co., Ltd. Dérivés de céphalosporine, procédés pour leur péparation et compositions pharmaceutiques
DE3840011A1 (de) * 1988-11-26 1990-05-31 Merck Patent Gmbh Benzoxazinderivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189287A2 (fr) * 1985-01-21 1986-07-30 Nippon Pharmaceutical Development Institute Company Limited Bêta-lactames antibiotiques
EP0254495A2 (fr) * 1986-07-21 1988-01-27 Sankei Pharmaceutical Company Limited Dérivés bêta-lactame, procédé pour leur préparation, compositions pharmaceutiques les contenant et intermédiaires

Also Published As

Publication number Publication date
FI883766A0 (fi) 1988-08-12
KR890003776A (ko) 1989-04-18
DK455288A (da) 1989-02-15
PH25646A (en) 1991-08-21
PT88274A (pt) 1989-06-30
DK455288D0 (da) 1988-08-12
AU614984B2 (en) 1991-09-19
MC1970A1 (fr) 1989-09-29
NO883590D0 (no) 1988-08-12
JPS6466190A (en) 1989-03-13
IL87374A0 (en) 1989-01-31
NO883590L (no) 1989-02-15
FI883766A (fi) 1989-02-15
PT88274B (pt) 1995-03-01
YU156388A (en) 1990-02-28
EP0303172A2 (fr) 1989-02-15
US5036064A (en) 1991-07-30
HUT47944A (en) 1989-04-28
US5319140A (en) 1994-06-07
AU2055488A (en) 1989-04-20
NZ225754A (en) 1991-04-26

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