PT88274A - Processo para a preparacao de novas oximas de cefalosporinas comportando um atomo de enxofre substituido por um radical fenilo no sitio oxima da cadeia e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novas oximas de cefalosporinas comportando um atomo de enxofre substituido por um radical fenilo no sitio oxima da cadeia e de composicoes farmaceuticas que os contem

Info

Publication number
PT88274A
PT88274A PT88274A PT8827488A PT88274A PT 88274 A PT88274 A PT 88274A PT 88274 A PT88274 A PT 88274A PT 8827488 A PT8827488 A PT 8827488A PT 88274 A PT88274 A PT 88274A
Authority
PT
Portugal
Prior art keywords
behavioring
oximates
cefalosporins
oxyme
atomus
Prior art date
Application number
PT88274A
Other languages
English (en)
Other versions
PT88274B (pt
Inventor
Erwin Gotschi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT88274A publication Critical patent/PT88274A/pt
Publication of PT88274B publication Critical patent/PT88274B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT88274A 1987-08-14 1988-08-12 Processo para a preparacao de novas oximas de cefalosporinas comportando um atomo de enxofre substituido por um radical fenilo no sitio oxima da cadeia e de composicoes farmaceuticas que os contem PT88274B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH313387 1987-08-14
CH472687 1987-12-03

Publications (2)

Publication Number Publication Date
PT88274A true PT88274A (pt) 1989-06-30
PT88274B PT88274B (pt) 1995-03-01

Family

ID=25692275

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88274A PT88274B (pt) 1987-08-14 1988-08-12 Processo para a preparacao de novas oximas de cefalosporinas comportando um atomo de enxofre substituido por um radical fenilo no sitio oxima da cadeia e de composicoes farmaceuticas que os contem

Country Status (15)

Country Link
US (2) US5036064A (pt)
EP (1) EP0303172A3 (pt)
JP (1) JPS6466190A (pt)
KR (1) KR890003776A (pt)
AU (1) AU614984B2 (pt)
DK (1) DK455288A (pt)
FI (1) FI883766A (pt)
HU (1) HUT47944A (pt)
IL (1) IL87374A0 (pt)
MC (1) MC1970A1 (pt)
NO (1) NO883590L (pt)
NZ (1) NZ225754A (pt)
PH (1) PH25646A (pt)
PT (1) PT88274B (pt)
YU (1) YU156388A (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
US5030724A (en) * 1990-01-22 1991-07-09 E. R. Squibb & Sons, Inc. Monobactam hydrazides containing catechol sulfonic acid groups
US20040197408A1 (en) * 2002-12-30 2004-10-07 Angiotech International Ag Amino acids in micelle preparation
US7537532B2 (en) * 2007-05-16 2009-05-26 Young Carl D Handle for implement and method
KR101719556B1 (ko) * 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
JP6151257B2 (ja) 2011-09-09 2017-06-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 肺内感染症の治療方法
JPWO2013051597A1 (ja) * 2011-10-04 2015-03-30 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
JP5681331B2 (ja) 2012-11-19 2015-03-04 三井化学株式会社 ポリエステル樹脂組成物とその製造方法
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
EP3100732A1 (en) 2013-03-15 2016-12-07 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
GB1596278A (en) * 1976-11-30 1981-08-26 Glaxo Operations Ltd 7-(-oxyimino-acetamino)cephalosporin derivatives
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
AU586215B2 (en) * 1985-01-21 1989-07-06 Nippon Pharmaceutical Development Institute Company Limited Novel ```-lactam antibiotics
FI872879A (fi) * 1986-07-21 1988-01-22 Sankei Yakuhin Kk --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes.
DE3840011A1 (de) * 1988-11-26 1990-05-31 Merck Patent Gmbh Benzoxazinderivate

Also Published As

Publication number Publication date
DK455288D0 (da) 1988-08-12
PH25646A (en) 1991-08-21
FI883766A (fi) 1989-02-15
FI883766A0 (fi) 1988-08-12
AU614984B2 (en) 1991-09-19
EP0303172A2 (de) 1989-02-15
US5319140A (en) 1994-06-07
NO883590L (no) 1989-02-15
YU156388A (en) 1990-02-28
JPS6466190A (en) 1989-03-13
DK455288A (da) 1989-02-15
IL87374A0 (en) 1989-01-31
HUT47944A (en) 1989-04-28
NO883590D0 (no) 1988-08-12
AU2055488A (en) 1989-04-20
EP0303172A3 (de) 1991-05-15
US5036064A (en) 1991-07-30
NZ225754A (en) 1991-04-26
MC1970A1 (fr) 1989-09-29
PT88274B (pt) 1995-03-01
KR890003776A (ko) 1989-04-18

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940804

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960229