EP0285496A1 - Vorrichtung zum Zusammenhalten und Verschliessen von Röhrchen für immunologische Dosierungen - Google Patents

Vorrichtung zum Zusammenhalten und Verschliessen von Röhrchen für immunologische Dosierungen Download PDF

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Publication number
EP0285496A1
EP0285496A1 EP88400673A EP88400673A EP0285496A1 EP 0285496 A1 EP0285496 A1 EP 0285496A1 EP 88400673 A EP88400673 A EP 88400673A EP 88400673 A EP88400673 A EP 88400673A EP 0285496 A1 EP0285496 A1 EP 0285496A1
Authority
EP
European Patent Office
Prior art keywords
plugs
tubes
bridge
test
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP88400673A
Other languages
English (en)
French (fr)
Inventor
Dominque L. Delacroix
Christian Saussez
Charles Tixhon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ire-Medgeniz SA
Original Assignee
Ire-Medgeniz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ire-Medgeniz SA filed Critical Ire-Medgeniz SA
Publication of EP0285496A1 publication Critical patent/EP0285496A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the present invention relates to test vessels, for example to test tubes, intended to be used in particular for the immunoassays of antigens and antibodies.
  • the present invention relates to a device adaptable to said containers allowing, inter alia, their closing and their assembly.
  • these tubes When these tubes, generally ten centimeters long, are delivered in the dosing kits, they are most often packaged by a number of ten in closed bags protecting the tubes from all impurities. This protection is particularly necessary when the tubes are coated with substances, for example monoclonal antibodies adsorbed on their internal wall. Losses of immunoreactivity can result from their pollution in the open air or even dropouts of the substances adsorbed on the walls of the tube can occur.
  • Opening the bag to take out a tube inevitably causes pollution of all the other tubes, which can become particularly annoying if they are not used simultaneously or quickly.
  • these tubes covered with an antibody of a given specificity are sometimes delivered with beads introduced inside said tubes and covered with an antibody endowed with another specificity, in order to allow the simultaneous assay of two analytes. through a single tube. It also often happens that these beads are coated with substances such as monoclonal antibodies, or frequently these beads spread out of the bag when it is opened.
  • the aim of the present invention is therefore to propose a device bringing together a whole series of functions facilitating the use of test tubes in immunoassays and thus offering everything at the same time - a means for closing the tubes, - a means for keeping the tubes connected to each other in one piece and in a certain order, - A means for closing and holding the tubes together but which also makes it possible to separate them, possibly individually, in any order.
  • closure means being useful as we have seen previously to preserve the cleanliness of the tube, preserve the stability of the possible coating adsorbed on its internal wall and maintain within it beads and also preserve them when they are coated with using a substance adsorbed on their surface.
  • the means of securing the different tubes to one another makes it possible to handle them all together in one piece, the tubes being well ordered with respect to each other and thus facilitates their use in the context of immunoassays.
  • the subject of the present invention is a device for assembling and closing several test containers, such as test tubes, useful in particular for immunological assays, device adaptable to the opening of test containers, characterized in that it consists of a plurality of plugs intended to close the opening of said containers, the plugs being connected to each other by a bridge of material made of a flexible elastic material, but ensuring a certain resistance to the device and to the assembly of tubes when adapted to them.
  • the term “material bridge” in fact means an amount of material sufficient to occupy essentially the entire space between the plugs, the latter therefore being able, however, to be partially hollowed out.
  • the material bridge is such that it ensures a certain resistance to the device itself and to the assembly of the tubes when the device is adapted to them. This holding essentially resides in a certain resistance to any lateral torsion applied to the tubes or to the device itself.
  • This device therefore combines well the sealing and sealing function of the various test pieces with all the advantages mentioned above.
  • the material bridge is made of plastic, in particular polypropylene or plastic of the elastomer type.
  • the device has a certain flexibility with for example the possibility that the lower ends of the assembled tubes are brought together with respect to each other so that the assembly can hold in one hand or even the possibility of detaching any tube by exerting a twist on said tube relative to the cap while ensuring good behavior of the other caps.
  • the device can consist of a strip comprising aligned plugs, connected by the material bridge, for example from 5 to 15 plugs.
  • the device may consist of a mat comprising a plurality of parallel alignments of plugs, the plugs being connected by the bridge of material.
  • the different alignments of parallel plugs can constitute a plurality of adjacent strips integral over their length but detachable from one another.
  • each strip has at one of its ends or at its two ends a tongue.
  • This feature allows the opening by simple pull on the tongue of all the plugs of the same band with a single gesture, as well as the progressive opening of each tube in the order of their arrangement.
  • the material bridge connecting the plugs directly adjacent to each other is partially hollowed out in its central part between two plugs of the same strip.
  • This characteristic gives the device additional flexibility, in particular improving the faculty of movement of a tube relative to the other tubes, while ensuring good resistance of said tubes.
  • the material recess avoids transmitting the deformation to the plugs when there is a twist of one or more tubes. Consequently, the plugs hold better despite a certain flexibility in the assembly of the device and the tubes.
  • the plugs and the material bridge are made of the same material and in particular the plugs come from the material with the bridge.
  • the devices according to the invention can be prepared by injection molding, in particular of polypropylene.
  • the mass of the stopper is hollowed out in its central and upper part, which makes it easier to adapt to the opening of the tubes as well as to remove it, the elastic force exerted by the stopper against the wall of the tube being thus reduced.
  • test vessels consisting of test tubes (1).
  • These tubes (1) being intended to be coated with a test substance on their internal wall, for example monoclonal antibodies, they can be made of any material, capable of being thus shaped for example in glass.
  • a test substance on their internal wall for example monoclonal antibodies
  • they can be made of any material, capable of being thus shaped for example in glass.
  • plastics such as polystyrene and polypropylene are very suitable.
  • Figure 1 there are therefore shown six polystyrene tubes adapted to the device of the invention. They are shown to scale, as well as the device of the invention. However, this dimension is not limiting of the scope of the invention, the scale corresponds to a diameter of 10 mm for the tubes.
  • This device is shown in top view in FIG. 2 and in side view in FIGS. 1 and 3.
  • the device according to the invention forms a whole, however, it can be analyzed in two parts, on the one hand, plugs 3 and, on the other hand, bridges of material 4 between said plugs.
  • Said plugs 3 adapt forcefully in the opening 5 of the tubes 1 shown in FIG. 3.
  • the device of the invention is made of a single elastomeric plastic, which facilitates the adaptation of the device according to the invention on the tubes.
  • material recesses 6 appear in the central part of the material bridges 4.
  • the material bridge therefore consists of two tongues 4a and 4b (FIG. 2) which provide the connection between the upper parts 7 of the plugs 3 ( Figures 1 and 3).
  • test vessels for example which are not of circular opening.
  • shape of the lower part 3 of the stopper must be adapted in accordance with that of the opening of the test container.
  • the device according to the invention comprises a tongue 8.
  • a tongue 8 can include such a tongue at each of its ends.
  • the device according to the invention comprises six plugs, but of course we can consider a device of the desired length and therefore with a variable number of plugs.
  • the device according to the invention is assembled on the test tubes by forcibly applying the lower part 3 of the plugs to the opening 5 of the test tubes, the elastic material constituting the device according to the invention makes this attachment hermetic.
  • the device of the invention By pulling on the tongue 8, the device of the invention can be separated from the tubes 1.
  • a pull on the tongue 8 makes it possible to separate the device from all the tubes in a single gesture, a weaker traction makes it possible to separate the device of the invention from only part of the tubes.
  • any tube can be detached from the device according to the present invention, without pulling on the tongue 8, but by simple twisting applied to the tube with respect to the horizontal plane of the upper part 9 of the plug 3.
  • the mass of the plug is hollowed out in its central part 9, which makes its adaptation to the opening 5 of the tube as well as its removal easier.
  • the elastic force exerted by the plug on the internal walls of the tube at the opening 5 is reduced.
  • Figure 4 is shown a device of the carpet type in top view.
  • the plugs 3 and the material bridge 4 come from material, the assembly was manufactured by injection molding of polypropylene.
  • the material bridge 4 occupies the entire space between the plugs, the lines 10 represent the grooves made in the material bridge. These lines correspond to an area where the thickness of the material is reduced so that by pulling on a tongue 8 at the end of a strip, the strip can be separated from the corresponding tubes, on the one hand, and the rest of the carpet, on the other hand.
  • This type of mat device is particularly suitable when the tubes are arranged in a flat support of the rack type of test tubes in the form of a rack-plane.
EP88400673A 1987-03-23 1988-03-21 Vorrichtung zum Zusammenhalten und Verschliessen von Röhrchen für immunologische Dosierungen Withdrawn EP0285496A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8703976A FR2613071B1 (fr) 1987-03-23 1987-03-23 Dispositif d'assemblage et de fermeture de tubes pour dosages immunologiques
FR8703976 1987-03-23

Publications (1)

Publication Number Publication Date
EP0285496A1 true EP0285496A1 (de) 1988-10-05

Family

ID=9349296

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88400673A Withdrawn EP0285496A1 (de) 1987-03-23 1988-03-21 Vorrichtung zum Zusammenhalten und Verschliessen von Röhrchen für immunologische Dosierungen

Country Status (2)

Country Link
EP (1) EP0285496A1 (de)
FR (1) FR2613071B1 (de)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0606534A1 (de) * 1993-01-11 1994-07-20 The Perkin-Elmer Corporation Schutzdeckel für Teströhrchen matrix
EP0916397A2 (de) * 1997-11-14 1999-05-19 Rohm And Haas Company Vorrichtung und Verfahren für die Anwendung in mehrfachen, simultanen Synthesen von allgemeinen Verbindungen
GB2334954A (en) * 1998-03-03 1999-09-08 Chromacol Ltd Array of connected closures
WO1999044745A1 (en) * 1998-03-03 1999-09-10 Chromacol Limited Closure plug array with blind bores
US6258323B1 (en) 1998-11-16 2001-07-10 Rohm And Haas Company Apparatus and method used in multiple, simultaneous synthesis of general compounds
EP1122181A2 (de) * 2000-02-02 2001-08-08 Soltec, Inc Flexible Matten mit Septumverschlusskappen für Probenbehälter-Arrays
DE102006001882A1 (de) * 2006-01-13 2007-07-19 Roche Diagnostics Gmbh Zu einem Verbund zusammengefasste Gruppe von Reagenzienträgern
WO2014075153A1 (en) * 2012-11-15 2014-05-22 THE WALKING EGG, vereniging zonder winstoogmerk Device and method for in vitro fertilisation.
GB2537637A (en) * 2015-04-21 2016-10-26 4Titude Ltd Improved cap strips
EP3055068A4 (de) * 2013-10-09 2017-07-05 University Of Utah Research Foundation Probenröhrchenadapter und verfahren zur verwendung davon
IT201700075491A1 (it) * 2017-07-05 2019-01-05 Eltek Spa Dispositivo per piastre di coltura cellulare multi-pozzetto, e relativo corredo
EP3967624A1 (de) * 2020-09-11 2022-03-16 A. Raymond et Cie Lieferplatte und verpackungssystem für medizinische elemente

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1211229A (fr) * 1958-12-17 1960-03-15 Assemblage temporaire de tubes cylindriques
US3098721A (en) * 1961-02-20 1963-07-23 Moeller Mfg Company Inc Multiple stopper unit
FR2007707A1 (de) * 1968-05-02 1970-01-09 Eppendore Geratebau
US4392389A (en) * 1980-10-07 1983-07-12 Dragerwerk Aktiengesellschaft Sampling tube having closing caps

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1211229A (fr) * 1958-12-17 1960-03-15 Assemblage temporaire de tubes cylindriques
US3098721A (en) * 1961-02-20 1963-07-23 Moeller Mfg Company Inc Multiple stopper unit
FR2007707A1 (de) * 1968-05-02 1970-01-09 Eppendore Geratebau
US4392389A (en) * 1980-10-07 1983-07-12 Dragerwerk Aktiengesellschaft Sampling tube having closing caps

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0606534A1 (de) * 1993-01-11 1994-07-20 The Perkin-Elmer Corporation Schutzdeckel für Teströhrchen matrix
CN1114702C (zh) * 1993-01-11 2003-07-16 Pe股份有限公司（纽约） 阵列式反应管的盖板
EP0916397A2 (de) * 1997-11-14 1999-05-19 Rohm And Haas Company Vorrichtung und Verfahren für die Anwendung in mehrfachen, simultanen Synthesen von allgemeinen Verbindungen
EP0916397A3 (de) * 1997-11-14 1999-05-26 Rohm And Haas Company Vorrichtung und Verfahren für die Anwendung in mehrfachen, simultanen Synthesen von allgemeinen Verbindungen
JP2002505183A (ja) * 1998-03-03 2002-02-19 クロマコル リミテッド ブラインド孔を有する閉鎖体プラグアレイ
US6202878B1 (en) 1998-03-03 2001-03-20 Chromacol Limited Closures
AU739801B2 (en) * 1998-03-03 2001-10-18 Chromacol Limited Closure plug array with blind bores
GB2334954B (en) * 1998-03-03 2002-01-16 Chromacol Ltd Array of connected closures for vials
WO1999044745A1 (en) * 1998-03-03 1999-09-10 Chromacol Limited Closure plug array with blind bores
GB2334954A (en) * 1998-03-03 1999-09-08 Chromacol Ltd Array of connected closures
US6258323B1 (en) 1998-11-16 2001-07-10 Rohm And Haas Company Apparatus and method used in multiple, simultaneous synthesis of general compounds
EP1122181A2 (de) * 2000-02-02 2001-08-08 Soltec, Inc Flexible Matten mit Septumverschlusskappen für Probenbehälter-Arrays
EP1122181A3 (de) * 2000-02-02 2003-05-28 Soltec, Inc Flexible Matten mit Septumverschlusskappen für Probenbehälter-Arrays
DE102006001882A1 (de) * 2006-01-13 2007-07-19 Roche Diagnostics Gmbh Zu einem Verbund zusammengefasste Gruppe von Reagenzienträgern
WO2014075153A1 (en) * 2012-11-15 2014-05-22 THE WALKING EGG, vereniging zonder winstoogmerk Device and method for in vitro fertilisation.
BE1021451B1 (nl) * 2012-11-15 2015-11-25 THE WALKING EGG vereniging zonder wonstoogmerk Inrichting voor in vitro fertilisatie
EP3055068A4 (de) * 2013-10-09 2017-07-05 University Of Utah Research Foundation Probenröhrchenadapter und verfahren zur verwendung davon
GB2537637A (en) * 2015-04-21 2016-10-26 4Titude Ltd Improved cap strips
IT201700075491A1 (it) * 2017-07-05 2019-01-05 Eltek Spa Dispositivo per piastre di coltura cellulare multi-pozzetto, e relativo corredo
WO2019008505A1 (en) * 2017-07-05 2019-01-10 Eltek S.P.A. DEVICE FOR PLATES FOR MULTI-WELL CELL CULTURE AND CORRESPONDING KIT
US11732228B2 (en) 2017-07-05 2023-08-22 Eltek S.P.A. Device for multi-well cell-culture plates, and corresponding kit
EP3967624A1 (de) * 2020-09-11 2022-03-16 A. Raymond et Cie Lieferplatte und verpackungssystem für medizinische elemente
FR3114081A1 (fr) * 2020-09-11 2022-03-18 A. Raymond Et Cie Plateau de livraison et systeme d’emballage d’elements medicaux

Also Published As

Publication number Publication date
FR2613071B1 (fr) 1991-05-03
FR2613071A1 (fr) 1988-09-30

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