EP0283629B1 - Conditionnement pour préparations extemporanées - Google Patents

Conditionnement pour préparations extemporanées Download PDF

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Publication number
EP0283629B1
EP0283629B1 EP19870440048 EP87440048A EP0283629B1 EP 0283629 B1 EP0283629 B1 EP 0283629B1 EP 19870440048 EP19870440048 EP 19870440048 EP 87440048 A EP87440048 A EP 87440048A EP 0283629 B1 EP0283629 B1 EP 0283629B1
Authority
EP
European Patent Office
Prior art keywords
flask
bottle
neck
liquid
packaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP19870440048
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0283629A1 (fr
Inventor
Jean Chibret
Charles Manni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEmballage et de Conditionnement SEMCO SAM
Original Assignee
Societe dEmballage et de Conditionnement SEMCO SAM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8704195A external-priority patent/FR2612892B2/fr
Application filed by Societe dEmballage et de Conditionnement SEMCO SAM filed Critical Societe dEmballage et de Conditionnement SEMCO SAM
Priority to AT87440048T priority Critical patent/ATE70517T1/de
Publication of EP0283629A1 publication Critical patent/EP0283629A1/fr
Application granted granted Critical
Publication of EP0283629B1 publication Critical patent/EP0283629B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end

Definitions

  • the present invention relates to improvements to assemblies intended for the extemporaneous preparation of suspensions or solutions of an active product, as described in particular in US Pat. No. 3,917,063.
  • Such an assembly is composed on the one hand of two hermetic bottles, the first of these bottles being intended to contain said active product generally in the form of dry lyophilized powder, and the second being intended to contain the liquid in which said product must be put in solution or in suspension at the time of its administration, and on the other hand connecting means allowing the communication of the two bottles, with a view, firstly, to introducing said liquid into the first bottle, then, in a second step, to suck, in the second bottle, the solution or suspension thus formed.
  • the first bottle is generally made of glass, and closed by an elastic stopper inserted in its neck, and having in its axis a channel covered by a thin perforable sealing membrane, glued or welded on one side, while the second bottle, made of flexible material, is closed by a dropper whose end has a diameter slightly smaller than that of the previous channel.
  • the mouth of the first bottle is surmounted by a socket, either internally threaded or smooth, while the flexible dropper bottle has a threaded cylindrical part which can be screwed into the sleeve of the first bottle.
  • the base of the threaded sleeve has outwardly a rim of the same diameter as the sealing membrane, and this sleeve is fixed to the bottle by means of '' a metal crimping ring supported on the upper side on this rim and on the lower side on the flange of the first bottle.
  • Document FR-A-2 160 668 proposes a different solution, avoiding this crimping problem.
  • this solution involves two separate connecting pieces, each snapped onto one of the bottles, the contents of which must be combined, and an additional piece constituting an intermediate plug carried by one of these two connecting pieces and traversed by a double needle intended to perforate each of the stoppers respectively closing each of said vials.
  • the aforementioned bushing and crimping ring are produced in a single molded piece of plastic material covering the neck of the first bottle, and by simple pushing, snap under said neck.
  • Said single piece is put in place without any centering problem, and stops without requiring the aforementioned separate crimping operation.
  • the means for closing the bottle containing the solid product remains, as in the conventional system, a stopper made of elastomeric material, pressed into the neck of the bottle, and crossed by a hole sealed with a perforable sealing membrane. As will be explained below, this arrangement ensures perfect sealing of the system.
  • the second bottle B is turned over and screwed into the socket 1 of the first bottle A.
  • This socket 1 comprises an upper part 2, having an internal thread 4, and a lower part 3 having a shoulder interior 5.
  • the bottle B ends in a dropper 6, connected to the body 7 of the bottle by a shoulder 8 externally threaded.
  • the bottle A is closed by a stopper 9 made of elastomeric material, crossed by a hole 10 sealed with a perforable sealing membrane 11, for example an aluminum polyethylene complex.
  • connection between said two bottles is made by means of the single piece 1, this piece being secured to the bottle A by snap-fastening of the shoulder 5 on the neck of the bottle A.
  • the part 1 when it is snapped onto the neck of the bottle A, exerts on the sealed cap a pressure, which seals it.
  • a tear-off tab forming a spacer.
  • This spacer prohibits, at the start of screwing, the descent of the stillicer to the membrane, the sealing function of which is thus guaranteed.
  • you tear the tab you can continue screwing, and puncture the membrane with the dropper.
  • Such a tab is similar to that shown in 13-14 on the aforementioned US patent, but is used for the first time according to the invention, in combination with a snap-on connecting piece.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
EP19870440048 1987-03-24 1987-07-30 Conditionnement pour préparations extemporanées Expired - Lifetime EP0283629B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT87440048T ATE70517T1 (de) 1987-03-24 1987-07-30 Verpackung von praeparaten fuer die zubereitung an ort und stelle.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8704195A FR2612892B2 (fr) 1972-06-13 1987-03-24 Conditionnements pour preparations extemporanees
FR8704195 1987-03-24

Publications (2)

Publication Number Publication Date
EP0283629A1 EP0283629A1 (fr) 1988-09-28
EP0283629B1 true EP0283629B1 (fr) 1991-12-18

Family

ID=9349443

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870440048 Expired - Lifetime EP0283629B1 (fr) 1987-03-24 1987-07-30 Conditionnement pour préparations extemporanées

Country Status (5)

Country Link
EP (1) EP0283629B1 (cs)
AT (1) ATE70517T1 (cs)
DE (1) DE3775382D1 (cs)
ES (1) ES2028122T3 (cs)
GR (1) GR3004068T3 (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105857890A (zh) * 2016-06-06 2016-08-17 洛阳海惠新材料股份有限公司 一种乙二醇锑的包装容器

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682088B1 (fr) * 1991-10-04 1994-06-10 Emballages Conditionnement Conditionnement pour la preparation extemporanee de produits medicamenteux.
ES2078194B1 (es) * 1994-06-03 1996-08-16 Cusi Lab Perfeccionamientos introducidos en envases contenedores de productos de dos componentes que han de mezclarse para su administracion.
US6237649B1 (en) * 1997-08-27 2001-05-29 Pentapharm Ag Dual vial connecting system for lyophilized products
AU8860198A (en) * 1998-07-10 2000-02-01 Pentapharm Ag Dual vial connecting system
WO2019113276A1 (en) * 2017-12-08 2019-06-13 Unipharma, Llc Container and method for reconstitution of substances
CN115998692A (zh) * 2023-02-15 2023-04-25 苏州欧康维视生物科技有限公司 一种阿托品药物产品及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1913926A1 (de) * 1969-03-19 1970-09-24 Hoechst Ag Zweikammerspritze
BE791634A (fr) * 1971-11-20 1973-05-21 Hoechst Ag Seringue a deux chambres
FR2427960A1 (fr) * 1978-06-06 1980-01-04 Dehais Claude Manchon pour etablir une communication temporaire entre deux recipients
FR2552404B1 (fr) * 1983-09-26 1987-12-24 Merck Sharp & Dohme Ensemble de preparation et de delivrance d'une solution, bouchon obturateur pour cet ensemble et procede de fabrication de ce bouchon

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105857890A (zh) * 2016-06-06 2016-08-17 洛阳海惠新材料股份有限公司 一种乙二醇锑的包装容器
CN105857890B (zh) * 2016-06-06 2018-03-23 洛阳海惠新材料股份有限公司 一种乙二醇锑的包装容器

Also Published As

Publication number Publication date
DE3775382D1 (de) 1992-01-30
EP0283629A1 (fr) 1988-09-28
GR3004068T3 (cs) 1993-03-31
ES2028122T3 (es) 1992-07-01
ATE70517T1 (de) 1992-01-15

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