EP0273962A4 - Compositions pour l'action prolongee d'agents antiplaque. - Google Patents

Compositions pour l'action prolongee d'agents antiplaque.

Info

Publication number
EP0273962A4
EP0273962A4 EP19870904629 EP87904629A EP0273962A4 EP 0273962 A4 EP0273962 A4 EP 0273962A4 EP 19870904629 EP19870904629 EP 19870904629 EP 87904629 A EP87904629 A EP 87904629A EP 0273962 A4 EP0273962 A4 EP 0273962A4
Authority
EP
European Patent Office
Prior art keywords
composition
composition according
weight
surfactant
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19870904629
Other languages
German (de)
English (en)
Other versions
EP0273962A1 (fr
Inventor
Robert L Goldemberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Oral Research Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oral Research Laboratories Inc filed Critical Oral Research Laboratories Inc
Publication of EP0273962A1 publication Critical patent/EP0273962A1/fr
Publication of EP0273962A4 publication Critical patent/EP0273962A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • Dental plaque and, hence, calculus are particularly prone to form at the gingival margin, i.e., the junction of the tooth and gingiva.
  • Supragingival plaque i.e., plaque that causes damage above the gingival margin
  • subgingival plaque i.e., plaque causing damage below the gingival margine also commonly occur.
  • the buildup of plaque at the gingival margin is believed to be a prime cause of gingivitis and other periodontal disorders.
  • Regular tooth brushing with a conventional dentifrice for some persons greatly retards or even prevents the accumulation of significant amounts of plaque and calculus.
  • formulations of the active anti-plaque ingredients include lozenges and chewing gum designed for sustained release of the active anti-plaque ingredients of this invention in the oral cavity over prolonged periods. Such compositions are particularly useful when the brushing of teeth is difficult or impossible.
  • the dentifrice compositions comprise a gel or paste carrier which includes detersive amounts of an oral surfactant, at least about 1% by weight of sodium benzoate and preferably, an effective amount of dental abrasive.
  • the carrier for the active ingredients may be a gel, paste, powder or the like capable of being applied to a toothbrush and brushed onto the teeth.
  • formulations of the above anti-plaque ingredients include at least about 6% by weight sodium benzoate.
  • Clay suspensions may be employed in the dentifrice compositions of this invention. These materials can have a marked detersive effect on soiled teeth and dentures by aiding the suspension of the active plaque removing ingredients in dentifrice compositions of this invention. In addition clays may function to absorb some of the bacteria loosened by the other ingredients of the dentifrice.
  • a particularly useful synthetic clay material is Laponite XLGTM commercially available from LaPorte Industries, Ltd., London, England, because it can be used to produce dentifrice gels.
  • effective amounts of sodium monofluorophosphate or sodium fluoride may be used to aid in preventing dental caries. This activity is in addition to the separate anti-caries activity which is believed to result from the use of the compositions of this invention to remove plaque from dental surfaces.
  • the oral ionic surfactants are preferred for use as the oral surfactant component, and suitable non- ionic, anionic, amphoteric and cationic surfactants may be employed in the dentrifrice, chewing gum and lozenge formulations. In fact, any surfactant exhibiting strong detersive properties can be used. Denture cleansers of the present invention may employ any number of surfactants, but the oral surfactants are preferred because they may minimize any damage to the surface of the dentures.
  • the gum base is prepared by heating and blending the various ingredients in a manner well-known in the art.
  • the actives be dissolved or solubilized by plasticizer or water to produce a highly concentrated solution and then the resulting solution added to the gum base.
  • Salts of benzoic acid or benzoic acid analogues are also used in the denture cleanser aspect of this invention. At least about 1% by weight of a salt of benzoic acid or an analogue of benzoic acid is useful, and preferably at least about 4% to about 15% by weight of sodium benzoate is used.
  • a nascent oxygen containing compound is preferably included i compositions of the denture cleanser of the present invention to aid in removing stains present on dentures.
  • salts of perborate and/or persulfate are used in the range of from about 2% to 25% by weight and preferably about 5% to about 17% by weight. Any water soluble perborate or persulfate salt can be used in the composition, but it is preferred that sodium perborate or persulfate be used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
EP19870904629 1986-07-11 1987-07-10 Compositions pour l'action prolongee d'agents antiplaque. Withdrawn EP0273962A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88462586A 1986-07-11 1986-07-11
US884625 1986-07-11

Publications (2)

Publication Number Publication Date
EP0273962A1 EP0273962A1 (fr) 1988-07-13
EP0273962A4 true EP0273962A4 (fr) 1988-07-27

Family

ID=25385011

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870904629 Withdrawn EP0273962A4 (fr) 1986-07-11 1987-07-10 Compositions pour l'action prolongee d'agents antiplaque.

Country Status (4)

Country Link
EP (1) EP0273962A4 (fr)
JP (1) JPH01501472A (fr)
AU (1) AU7694787A (fr)
WO (1) WO1988000463A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994262A (en) * 1988-10-14 1991-02-19 The Procter & Gamble Company Oral compositions
FR2647308A1 (fr) * 1989-08-22 1990-11-30 Maestre Reyes Jose Composition de gomme a macher et procede de fabrication
EP0414932A1 (fr) * 1989-08-29 1991-03-06 Csemege Edesipari Gyar Composition de chewing-gum
US4992256A (en) * 1989-09-27 1991-02-12 Colgate-Palmolive Company Plaque disclosing compositions
US5028413A (en) * 1990-03-21 1991-07-02 Bausch & Lomb Incorporated Novel fluoride-containing dentifrice
DE4222739A1 (de) * 1992-07-10 1994-01-13 Henkel Kgaa Flüssige Zahnreinigungsmittel
BR9307332A (pt) * 1992-10-28 1999-06-01 Den Mat Corp Lavagem bucal antibacteriana
US6485739B2 (en) 2000-03-10 2002-11-26 Warner-Lambert Company Stain removing chewing gum and confectionery compositions, and methods of making and using the same
US7041277B2 (en) 2000-03-10 2006-05-09 Cadbury Adams Usa Llc Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same
US6471945B2 (en) * 2000-03-10 2002-10-29 Warner-Lambert Company Stain removing chewing gum and confectionery compositions, and methods of making and using the same
US7588696B2 (en) 2003-06-12 2009-09-15 Cargill, Incorporated Antimicrobial water softener salt and solutions
US7658959B2 (en) 2003-06-12 2010-02-09 Cargill, Incorporated Antimicrobial salt solutions for food safety applications
US7883732B2 (en) 2003-06-12 2011-02-08 Cargill, Incorporated Antimicrobial salt solutions for cheese processing applications
US7090882B2 (en) 2003-06-12 2006-08-15 Cargill, Incorporated Antimicrobial salt solutions for food safety applications
US9271904B2 (en) 2003-11-21 2016-03-01 Intercontinental Great Brands Llc Controlled release oral delivery systems
US7727565B2 (en) 2004-08-25 2010-06-01 Cadbury Adams Usa Llc Liquid-filled chewing gum composition
US9198448B2 (en) 2005-02-07 2015-12-01 Intercontinental Great Brands Llc Stable tooth whitening gum with reactive ingredients
US8486472B2 (en) 2006-01-18 2013-07-16 Cargill, Incorporated Antimicrobial salt solutions for food safety applications
KR101384328B1 (ko) 2006-03-23 2014-04-10 가오 가부시키가이샤 세균막 형성 억제제 조성물
JP2008100964A (ja) * 2006-10-20 2008-05-01 Kao Corp バイオフィルム生成抑制剤組成物
JP5209864B2 (ja) * 2006-10-20 2013-06-12 花王株式会社 バイオフィルム生成抑制剤組成物
AU2007235359B2 (en) 2006-04-05 2011-03-10 Intercontinental Great Brands Llc Calcium phosphate complex and salts in oral delivery systems
AU2007235360B2 (en) 2006-04-05 2010-11-25 Intercontinental Great Brands Llc Impact of calcium phosphate complex on dental caries
DE102012007212A1 (de) 2012-04-11 2013-10-17 Merz Pharma Gmbh & Co. Kgaa Zubereitung zur topischen Anwendung auf Schleimhäuten mit Polyhexanid als Wirkstoff
WO2015151915A1 (fr) * 2014-03-31 2015-10-08 ライオン株式会社 Composition de dentifrice

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1627963A (en) * 1920-01-30 1927-05-10 Henry C Fuller Medicinal product
FR737220A (fr) * 1931-09-03 1932-12-08 Henkel & Cie Gmbh Produit dentifrice et d'hygiène buccale
SE321765B (fr) * 1968-11-29 1970-03-16 K Holmstroem
US4152418A (en) * 1970-04-01 1979-05-01 Lever Brothers Company Zinc and enzyme mouthwash and mouthwash concentrate for reducing dental plaque and calculus formation
US3772431A (en) * 1972-09-21 1973-11-13 W Mlkvy Effervescent mouthwash tablet
US3887701A (en) * 1974-11-01 1975-06-03 Colgate Palmolive Co Antibacterial oral compositions containing preservative-antioxidants
GB2095694B (en) * 1981-03-31 1984-08-01 Hollaway E R Ltd Tooth cleaning compositions
US4362639A (en) * 1981-04-03 1982-12-07 Warner-Lambert Company Cleanser with improved afterodor and tarnish resistance
US4666708A (en) * 1984-01-27 1987-05-19 Oral Research Laboratories, Inc. Dental rinse
US4585649A (en) * 1984-12-21 1986-04-29 Ici Americas Inc. Dentifrice formulation and method of treating teeth, mouth and throat therewith to reduce plaque accumulation and irritation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No relevant documents have been disclosed. *
See also references of WO8800463A1 *

Also Published As

Publication number Publication date
AU7694787A (en) 1988-02-10
EP0273962A1 (fr) 1988-07-13
JPH01501472A (ja) 1989-05-25
WO1988000463A1 (fr) 1988-01-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19880323

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19880727

EL Fr: translation of claims filed
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PFIZER INC.

17Q First examination report despatched

Effective date: 19900802

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19901213