Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q13/00—Formulations or additives for perfume preparations

Definitions

• This invention relates generally to the use of hyaluroni ⁇ acid/hyaluronate as a means for achieving molecular encapsulation of various substances.
• the inven ⁇ tion specifically relates to the use of hyaluronic acid/ hyaluronate as a molecular encapsulant (fixative) for various fragrance products.
• a fixative in the perfume art is a substance, which, when combined with a fragrance or a cosmetic product including a fragrance, retards the rate of evaporation of the fragrance thus rendering its odor more persistent.
• a fragrance After a fragrance has been formulated and compounded, it is usually added to a cosmetic product, e.g., alcoholic fragrance solutions and aerosols including perfumes, toilet waters, colognes or bath oils, creams, gels, emollients, lotions, air fresheners, and deoderants .
• a fragrance may include various perfume oils and mixtures of a wide variety of material (animal and plant) and synthetic fragrant substances.
• Such fragrant substan ⁇ ces are typically selected from a wide variety of essential oils, absolutes, isolates, expressed oils, animal secre ⁇ tions, resins, gums, balsams, exudations and synthetic aliphatic and aromatic chemicals.
• fragrance compositions all cos ⁇ metic products and fragrant compositions will be referred to herein generally as fragrance compositions .
• hyaluronic acid/hyaluronate in fragrance compositions will add other benefits to those preparations in addition to the entrapment of scent.
• fragrances cause irritation of the skin of some individuals to which those scents are applied.
• the natural composition of hyaluronic acid/ hyaluronate in combination with the tendency to bind fragrance will reduce the exposure of sensitive skin to direct contact with a fragrance, thus reducing the opportunity for irritation to develop.
• Hyaluronic acid (hereinafter referred to as "HA” . as well as its salts , such as sodium hyaluronate (hereinafter referred to as "NaHA” ; NaHA is also used to refer generally to any salt form of HA herein) is a known, naturally occuring high viscosity glycosaminoglycan having alternating p 1-3 glucuronidic and /3 1-4 glucosaminidic bonds. It may also be described as a polysaccharide com ⁇ posed of alternate A -D-glucopyranosyluronic acid and 2-acetamido-2-deoxy- ⁇ -D-glucopyranosyl units linked (1 - 3) and (1 - 4), respectively.
• the molecular weight of this material is generally within the range of 50,000 to 8,000,000 (although there are reports of HA having molecu ⁇ lar weights as high as 13,000,000) depending on the source, method of isolation and method of determination. Typically, it exists in either the acid or the salt form either of which may be used in this invention.
• animal tissue e.g. in umbilical cord, vitreous humor, synovial fluid, rooster combs, body joints, group A and C hemolytic streptococci and in human skin .
• HA muccopolysaccharide
• U.S. Patent 2,975,104 describes the biosynthesis of HA, as does British Patent 1,557,755.
• Kjems and Lebeck in Acta Path . microbiol . scand. , Section B. , 84t_: 162-164 (1976) describe the strep- tococcal biosynthesis of a relatively low molecular weight HA.
• HA isolation and characterization of HA is described in Meyer et al, J. Biol . Chem. 107, 629 (1934); J. Biol. Chem., 114, 689 (1936); Balazs, Fed. Proc. 17, 1086 (1958); Laurent et al ; Biochim. Biophys . Acta 42,476 (1960).
• the structure of HA was elucidated by Weissman et al, J. Am. Chem. Soc. 76, 1753 (1954) and Meyer, Fed. Proc. 17, 1075 (1958).
• Sodium hyaluronate the salt form of HA
• HA Sodium hyaluronate
• Pharmacia AB Uppsala, Sweden
• AMVISC Med-Chem Products, Inc. (236 West Cummings Park, Woburn, MA 01801) from rooster combs
• HYALURE TM produced in various grades including a cosmetic grade, by Diagnostic, Inc., 1955 West County Road B2, St., Paul, Minnesota 55113 using microbial fermentation.
• This invention provides the fixation of various substances by means of HA/NaHA and its ability for molecu ⁇ lar encapsulation. It especially provides improved fra ⁇ grance compositions which exhibit prolonged persistence of the fragrance. This is believed due to the entrapment of the fragrant components of the composition by the HA or NaHA, which is included in the compositions according to this invention. The same persistent fragrance effect is obtained when either HA or NaHA is included in the fragrant compositio . Description of the Preferred Embodiment
• HA or NaHA used for the purposes of this invention may be obtained or prepared in any variety of ways, as referred to hereinabove.
• the HA is used in an aqueous solution form.
• aqueous solution can be prepared in any relative amounts, .005% - 1% NaHA, balance water, being most typi ⁇ cal, the 1% solution being quite viscous (like a rich cream) .
• Perfume as an example of a fragrance com ⁇ position, is usually composed of a solvent such as alcohol plus a concentrated fragrant essence.
• the NaHA solution may be mixed with the perfume or any other fragrant com ⁇ position in any relative amount which is not particularly critical. The amount will be determined by the particular objective intended. For example, small amounts may be used to enable one to provide a persistent perfume which main ⁇ tains its normal appearance. Larger amounts may be used to increase persistence and to increase the viscosity of the perfume.
• KEORA Jean Couturier
• test results A fresh cotton swab was dipped into the selected test perfume solution (A or B above), wiped on the side of the container neck four times, and a two inch streak placed on the inside of the test subjects' wrist at the beginning of the work day.
• the opposite wrist received the control solution of that subjects' scent choice (A or B above).
• the subjects were asked to monitor their wrists to deter ⁇ mine if any difference could be detected during the course of the work day. The subjects did not know the nature of the solutions placed on each wrist.
• test subjects eight (50%) of the test subjects could distinguish no difference between either the control or the test arm and after the test could't determine scent or odor endpoints of either arm.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Fats And Perfumes (AREA)
• Cosmetics (AREA)

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• 1984
  • 1984-11-13 EP EP19840904297 patent/EP0179070A1/de not_active Withdrawn
  • 1984-11-13 AU AU36199/84A patent/AU3619984A/en not_active Abandoned
  • 1984-11-13 WO PCT/US1984/001848 patent/WO1985004803A1/en not_active Application Discontinuation
• 1985
  • 1985-12-12 FI FI854930A patent/FI854930A/fi not_active Application Discontinuation

Non-Patent Citations (1)

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