EP0178178A3 - Dérivés de purine - Google Patents

Dérivés de purine Download PDF

Info

Publication number
EP0178178A3
EP0178178A3 EP85307283A EP85307283A EP0178178A3 EP 0178178 A3 EP0178178 A3 EP 0178178A3 EP 85307283 A EP85307283 A EP 85307283A EP 85307283 A EP85307283 A EP 85307283A EP 0178178 A3 EP0178178 A3 EP 0178178A3
Authority
EP
European Patent Office
Prior art keywords
carbon atoms
hydrogen
alkyl
zero
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP85307283A
Other languages
German (de)
English (en)
Other versions
EP0178178A2 (fr
Inventor
Jagadish C. Sircar
Garry W. Pinter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/767,202 external-priority patent/US4772606A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of EP0178178A2 publication Critical patent/EP0178178A2/fr
Publication of EP0178178A3 publication Critical patent/EP0178178A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP85307283A 1984-10-12 1985-10-11 Dérivés de purine Withdrawn EP0178178A3 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66015284A 1984-10-12 1984-10-12
US660152 1984-10-12
US767202 1985-08-22
US06/767,202 US4772606A (en) 1985-08-22 1985-08-22 Purine derivatives

Publications (2)

Publication Number Publication Date
EP0178178A2 EP0178178A2 (fr) 1986-04-16
EP0178178A3 true EP0178178A3 (fr) 1987-08-12

Family

ID=27097992

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85307283A Withdrawn EP0178178A3 (fr) 1984-10-12 1985-10-11 Dérivés de purine

Country Status (15)

Country Link
EP (1) EP0178178A3 (fr)
KR (1) KR860003255A (fr)
AU (1) AU584126B2 (fr)
CA (1) CA1260934A (fr)
DK (1) DK458485A (fr)
ES (2) ES8609328A1 (fr)
FI (1) FI853891L (fr)
GR (1) GR852468B (fr)
HU (1) HU197747B (fr)
IL (1) IL76546A (fr)
NO (1) NO854050L (fr)
NZ (1) NZ213798A (fr)
OA (1) OA08120A (fr)
PH (1) PH22811A (fr)
PT (1) PT81293B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
DE69031337T2 (de) * 1989-02-27 1998-03-05 Biocryst 9-substituierte-8-unsubstituierte-9-deazaguanine
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5217983A (en) * 1992-03-27 1993-06-08 Du Pont Merck Pharmaceutical Company (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories
US5272169A (en) * 1992-03-27 1993-12-21 The Dupont Merck Pharmaceutical Company (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories
JPH10507171A (ja) * 1994-10-05 1998-07-14 カイロサイエンス・リミテッド Ｐｎｐインヒビターとしてのプリンおよびグアニン化合物
DE19501482A1 (de) * 1995-01-19 1996-07-25 Bayer Ag 2,9-disubstituierte Purin-6-one
GB9520364D0 (en) * 1995-10-05 1995-12-06 Chiroscience Ltd Compouundds
GB9520363D0 (en) * 1995-10-05 1995-12-06 Chiroscience Ltd Compounds
DE19541264A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Purin-6-on-derivate
EP2336133A1 (fr) 2001-10-30 2011-06-22 Conforma Therapeutics Corporation Analogues de purine présentant une activité inhibitrice de HSP90
BRPI0414533A (pt) 2003-09-18 2006-11-07 Conforma Therapeutics Corp composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90
CA2602257A1 (fr) * 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyle pyrrolopyrimidines et analogues associes en tant qu'inhibiteurs de hsp90
EP2773207B1 (fr) * 2011-10-31 2018-03-07 Merck Sharp & Dohme Corp. Aminopyrimidinones en tant qu'inhibiteurs de kinases associées au récepteur de l'interleukine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844578A (en) * 1955-09-14 1958-07-22 Du Pont Pyrimidine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844578A (en) * 1955-09-14 1958-07-22 Du Pont Pyrimidine derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, vol. 10, no. 1, January 1967, pages 62-64, American Chemical Society, Washington, US; B.R. BAKER et al.: "Irreversible enzyme inhibitors. LXXIV. Inhibitors of guanine deaminase. II. Studies on bulk tolerance within enzyme-inhibitor complexes" *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol, 81, no. 9, 14th May 1959, pages 3046-3051, American Chemical Society, Washington, US; H.C: KOPPEL et al: "Potential purine antagonists. XIX. Synthesis of some 9-alkyl(aryl)-2-amino-6-substituted purines and related v-triazolo[d]pyrimidines" *

Also Published As

Publication number Publication date
NO854050L (no) 1986-04-14
HUT40131A (en) 1986-11-28
DK458485A (da) 1986-04-13
FI853891L (fi) 1986-04-13
NZ213798A (en) 1989-01-06
IL76546A (en) 1988-12-30
ES553606A0 (es) 1987-12-16
ES8609328A1 (es) 1986-09-01
CA1260934A (fr) 1989-09-26
KR860003255A (ko) 1986-05-21
IL76546A0 (en) 1986-02-28
PH22811A (en) 1988-12-27
ES8801273A1 (es) 1987-12-16
EP0178178A2 (fr) 1986-04-16
PT81293B (pt) 1988-02-17
HU197747B (en) 1989-05-29
FI853891A0 (fi) 1985-10-07
ES547805A0 (es) 1986-09-01
DK458485D0 (da) 1985-10-08
AU584126B2 (en) 1989-05-18
OA08120A (fr) 1987-03-31
AU4829285A (en) 1986-04-17
PT81293A (en) 1985-11-01
GR852468B (fr) 1986-02-12

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18D Application deemed to be withdrawn

Effective date: 19930705

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PINTER, GARRY W.

Inventor name: SIRCAR, JAGADISH C.