EP0119107B1 - Nouveaux dérivés du bicyclo(4.2.0)octatriène-1,3,5, leur préparation et leur application en thérapeutique - Google Patents
Nouveaux dérivés du bicyclo(4.2.0)octatriène-1,3,5, leur préparation et leur application en thérapeutique Download PDFInfo
- Publication number
- EP0119107B1 EP0119107B1 EP84400056A EP84400056A EP0119107B1 EP 0119107 B1 EP0119107 B1 EP 0119107B1 EP 84400056 A EP84400056 A EP 84400056A EP 84400056 A EP84400056 A EP 84400056A EP 0119107 B1 EP0119107 B1 EP 0119107B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- bicyclo
- octatriene
- cyano
- acid
- imidazolinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT84400056T ATE22557T1 (de) | 1983-01-14 | 1984-01-12 | Bicyclo(4.2.0)oktatriene-1,3,5 derivate, verfahren zu deren herstellung und deren therapeutische anwendung. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8300502 | 1983-01-14 | ||
FR8300502A FR2539415B1 (fr) | 1983-01-14 | 1983-01-14 | Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0119107A1 EP0119107A1 (fr) | 1984-09-19 |
EP0119107B1 true EP0119107B1 (fr) | 1986-10-01 |
Family
ID=9284924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP84400056A Expired EP0119107B1 (fr) | 1983-01-14 | 1984-01-12 | Nouveaux dérivés du bicyclo(4.2.0)octatriène-1,3,5, leur préparation et leur application en thérapeutique |
Country Status (17)
Country | Link |
---|---|
US (1) | US4567181A (da) |
EP (1) | EP0119107B1 (da) |
JP (1) | JPS59139361A (da) |
AT (1) | ATE22557T1 (da) |
AU (1) | AU562182B2 (da) |
CA (1) | CA1212111A (da) |
DE (1) | DE3460834D1 (da) |
DK (1) | DK12584A (da) |
ES (1) | ES8503681A1 (da) |
FR (1) | FR2539415B1 (da) |
GR (1) | GR79170B (da) |
IL (1) | IL70684A (da) |
NO (1) | NO159379C (da) |
NZ (1) | NZ206833A (da) |
OA (1) | OA07633A (da) |
PT (1) | PT77961B (da) |
ZA (1) | ZA84261B (da) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0166937B1 (en) * | 1984-06-06 | 1991-08-28 | Abbott Laboratories | Adrenergic compounds |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
US4923444A (en) * | 1988-12-19 | 1990-05-08 | Ivac Corporation | Negative pressure measurement system |
CA1321751C (en) * | 1989-02-21 | 1993-08-31 | Eugene C. Crichlow | Mechanism mediating ruminal stasis in ruminal lactic acidosis |
JP3761960B2 (ja) * | 1996-03-19 | 2006-03-29 | 仁美 鈴木 | ガス中の二酸化炭素の除去方法 |
FR2935381B1 (fr) * | 2008-08-29 | 2010-12-17 | Servier Lab | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
US9562136B2 (en) | 2011-07-04 | 2017-02-07 | Cambridge Display Technology, Ltd. | Polymers, monomers and methods of forming polymers |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE551610A (da) * | 1955-10-13 | 1900-01-01 | ||
US3287469A (en) * | 1963-09-27 | 1966-11-22 | Du Pont | Naphthyl-and indanylimidazolines |
US3927023A (en) * | 1974-05-24 | 1975-12-16 | Warner Lambert Co | Imidazolyl benzofurans |
US4226876A (en) * | 1976-12-20 | 1980-10-07 | Burroughs Wellcome Co. | Arthropodicidal imidazoline derivatives |
DE2933962A1 (de) * | 1979-08-22 | 1981-03-26 | Hoechst Ag, 65929 Frankfurt | Verfahren zur herstellung von 4,5-dichlor-imidazolen. |
NZ201219A (en) * | 1981-07-28 | 1984-10-19 | Reckitt & Colmann Prod Ltd | Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions |
-
1983
- 1983-01-14 FR FR8300502A patent/FR2539415B1/fr not_active Expired
-
1984
- 1984-01-12 GR GR73503A patent/GR79170B/el unknown
- 1984-01-12 ZA ZA84261A patent/ZA84261B/xx unknown
- 1984-01-12 EP EP84400056A patent/EP0119107B1/fr not_active Expired
- 1984-01-12 AT AT84400056T patent/ATE22557T1/de not_active IP Right Cessation
- 1984-01-12 DE DE8484400056T patent/DE3460834D1/de not_active Expired
- 1984-01-12 DK DK12584A patent/DK12584A/da not_active Application Discontinuation
- 1984-01-13 IL IL70684A patent/IL70684A/xx not_active IP Right Cessation
- 1984-01-13 NO NO840131A patent/NO159379C/no unknown
- 1984-01-13 OA OA58205A patent/OA07633A/xx unknown
- 1984-01-13 PT PT77961A patent/PT77961B/pt unknown
- 1984-01-13 JP JP59004649A patent/JPS59139361A/ja active Granted
- 1984-01-13 AU AU23277/84A patent/AU562182B2/en not_active Ceased
- 1984-01-13 NZ NZ206833A patent/NZ206833A/en unknown
- 1984-01-13 ES ES528877A patent/ES8503681A1/es not_active Expired
- 1984-01-16 CA CA000445334A patent/CA1212111A/fr not_active Expired
- 1984-04-05 US US06/596,932 patent/US4567181A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ206833A (en) | 1987-02-20 |
NO840131L (no) | 1984-07-16 |
CA1212111A (fr) | 1986-09-30 |
ES528877A0 (es) | 1985-03-01 |
JPS632957B2 (da) | 1988-01-21 |
AU2327784A (en) | 1984-07-19 |
GR79170B (da) | 1984-10-02 |
US4567181A (en) | 1986-01-28 |
IL70684A0 (en) | 1984-04-30 |
NO159379C (no) | 1988-12-21 |
DK12584D0 (da) | 1984-01-12 |
PT77961B (fr) | 1986-06-18 |
AU562182B2 (en) | 1987-06-04 |
FR2539415B1 (fr) | 1985-09-13 |
EP0119107A1 (fr) | 1984-09-19 |
IL70684A (en) | 1987-07-31 |
ATE22557T1 (de) | 1986-10-15 |
FR2539415A1 (fr) | 1984-07-20 |
PT77961A (fr) | 1984-02-01 |
DK12584A (da) | 1984-07-15 |
NO159379B (no) | 1988-09-12 |
DE3460834D1 (en) | 1986-11-06 |
ES8503681A1 (es) | 1985-03-01 |
JPS59139361A (ja) | 1984-08-10 |
ZA84261B (en) | 1984-08-29 |
OA07633A (fr) | 1985-05-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0591057B1 (fr) | Arylalkyl(thio)amides ayant une affinité sélective pour les récepteurs de la mélatonine et leur procédé de préparation | |
FR2607493A1 (fr) | Nouveaux composes pharmacologiquement actifs, leurs procedes de preparation et les compositions en contenant | |
EP0506532A1 (fr) | Nouveaux dérivés de l'indole, procédé de préparation et médicaments les contenant | |
WO2004031160A2 (fr) | Composes derives de la 2-thiohydantoïne et leur utilisation pour le traitement du diabete | |
EP0373998A1 (fr) | Ethers d'oxime de propénone, procédé pour leur préparation et compositions pharmaceutiques les contenant | |
CH671574A5 (da) | ||
EP0025727B1 (fr) | Dérivés de l'indole, procédé pour leur préparation et médicaments les contenant | |
EP0049203A1 (fr) | Nouvelles benzoxazolinones substituées en 6 par une chaîne aminoalcool ou aminocétone, leur préparation et leur application en thérapeutique | |
EP0119107B1 (fr) | Nouveaux dérivés du bicyclo(4.2.0)octatriène-1,3,5, leur préparation et leur application en thérapeutique | |
EP0151072A2 (fr) | Dérivés de l'acide méthylènediphosphonique, procédé d'obtention et compositions pharmaceutiques antirhumatismales les contenant | |
EP0063509A1 (fr) | Nouveaux dérivés de pipérazino-2 pyrimidine, procédés pour leur préparation, médicaments les contenant et leur utilisation comme intermédiaires pour la fabrication de médicaments | |
EP0122827B1 (fr) | (Carbéthoxy-2 benzalkylamido-4 phénoxy)-1 amino-3 propanols-2, leurs préparations et leurs utilisations en thérapeutique | |
EP0150139B1 (fr) | Dérivés de l'indole éthénylphénol, leurs sels, procédé de préparation, application à titre de médicaments,et compositions les renfermant | |
EP0021924B1 (fr) | Dérivés de l'indole, procédé pour leur préparation, leur application comme médicaments et compositions pharmaceutiques les contenant | |
LU81562A1 (fr) | Derives de phenyl-1 piperazine | |
EP0385848A1 (fr) | Nouveaux dérivés benzoxazolinoniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent | |
EP0201400B1 (fr) | Dérivés du 4-phénylpropyl indole et leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant | |
EP0173597A1 (fr) | Nouveaux éther-oxydes dérivés de cyclopropylphénols | |
EP0050072B1 (fr) | Nouvelles cyclopropylméthyl pipérazines, leur procédé de préparation et leur application en thérapeutique | |
FR2547822A1 (fr) | Acylpiperazinoquinazolines substituees utiles comme medicaments et procede pour leur preparation | |
EP0143016A1 (fr) | Dérivés de 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-N-phényl acétamide, leur préparation et leur application en thérapeutique | |
EP0275762B1 (fr) | Dérivés de l'indole carboxamide ainsi que leurs sels, procédé et intermédiaires de préparation, application à titre de médicaments de ces dérivés et compositions les renfermant | |
EP0161143A1 (fr) | Nouvelles 1,2,4-thiadiazines et leurs sels, leur procédé et leurs intermédiaires de préparation, leur application à titre de médicaments et les compositions les renfermant | |
EP0101379A1 (fr) | Benzamides, leurs sels, procédé pour leur préparation et compositions pharmaceutiques les renfermant | |
FR2571965A1 (fr) | Medicaments a base de nouveaux derives de la 4 h-dioxino-(4,5-c)-pyridine. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19850118 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
REF | Corresponds to: |
Ref document number: 22557 Country of ref document: AT Date of ref document: 19861015 Kind code of ref document: T |
|
REF | Corresponds to: |
Ref document number: 3460834 Country of ref document: DE Date of ref document: 19861106 |
|
ITF | It: translation for a ep patent filed |
Owner name: SOCIETA' ITALIANA BREVETTI S.P.A. |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed | ||
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Effective date: 19890113 |
|
EPTA | Lu: last paid annual fee | ||
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 19950118 Year of fee payment: 12 |
|
EUG | Se: european patent has lapsed |
Ref document number: 84400056.2 Effective date: 19891205 |
|
ITTA | It: last paid annual fee | ||
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: AT Payment date: 19951122 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: LU Payment date: 19960101 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 19960103 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 19960126 Year of fee payment: 13 Ref country code: BE Payment date: 19960126 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 19960131 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 19960201 Year of fee payment: 13 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Effective date: 19960930 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 19970112 Ref country code: GB Effective date: 19970112 Ref country code: AT Effective date: 19970112 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Effective date: 19970131 Ref country code: CH Effective date: 19970131 Ref country code: BE Effective date: 19970131 |
|
BERE | Be: lapsed |
Owner name: ADIR Effective date: 19970131 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Effective date: 19970801 |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 19970112 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
NLV4 | Nl: lapsed or anulled due to non-payment of the annual fee |
Effective date: 19970801 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Effective date: 19971001 |