EP0034595A1 - Nouvelles compositions pour la revelation et l'inhibition de la plaque dentaire - Google Patents
Nouvelles compositions pour la revelation et l'inhibition de la plaque dentaireInfo
- Publication number
- EP0034595A1 EP0034595A1 EP80901502A EP80901502A EP0034595A1 EP 0034595 A1 EP0034595 A1 EP 0034595A1 EP 80901502 A EP80901502 A EP 80901502A EP 80901502 A EP80901502 A EP 80901502A EP 0034595 A1 EP0034595 A1 EP 0034595A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- dental plaque
- compositions according
- constituents
- compositions
- revealing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract 14
- 208000002064 Dental Plaque Diseases 0.000 title claims abstract 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims abstract 3
- 239000000470 constituent Substances 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 1
- 229960003260 chlorhexidine Drugs 0.000 claims 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 claims 1
- 239000007793 ph indicator Substances 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims 1
- SJEYSFABYSGQBG-UHFFFAOYSA-M Patent blue Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 SJEYSFABYSGQBG-UHFFFAOYSA-M 0.000 abstract 1
- 239000000980 acid dye Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940034610 toothpaste Drugs 0.000 abstract 1
- 239000000606 toothpaste Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
Definitions
- the present invention relates to new compositions for dental hygiene and treatment having, among other aims, that of revealing and treating dental plaque.
- a dental plaque denotes a film depositing on the surface of the teeth and which is interposed between the teeth and the oral environment. It is essentially made up of a layer of more or less denatured natural and salivary proteins, salivary mucin and various living or dead microorganisms. Physico-chemically, dental plaque has properties linked to its high protein content. This largely protein film therefore constitutes a barrier between the teeth and the buccal volume in which the free saliva is slightly acidic or substantially neutral (pH 5.6 to 7.6 most generally). It tends to be more acidic at rest than during the active period.
- the object of the present invention is therefore, when the user so desires, and in particular when he is washing his teeth, to allow him to see appear, thanks to a clear coloration, said dental plaque, coloration then easily eliminated by washing and / or conventional brushing generally carried out using toothpaste.
- compositions revealing dental plaque in accordance with the invention, only, which requires subsequent elimination, or to use a unique composition including that according to the invention revealing dental plaque by coloring and the constituents of any conventional ifrice tooth.
- the latter solution being the simplest, we will insist on it in the examples which follow, without this limiting the scope of the invention.
- compositions according to the present invention therefore contain at least one body hereinafter called a developer which brings to the dental plaque a color which does not appear or appears differently on the other surfaces of the oral cavity.
- a developer which brings to the dental plaque a color which does not appear or appears differently on the other surfaces of the oral cavity.
- This staining of dental plaque can be obtained using any product which, in sufficient concentration, fixes physically, chemically and / or biologically, a layer, a film or particles, the time necessary for observation, and can then be easily removed. It is therefore important that the coloration be apparent during this observation, so that it can appear only at the time of contact between developer and dental plaque, by physical, chemical and / or biological interaction between the developers and one or more constituents of dental plaque.
- compositions having the following properties:
- a toothpaste is prepared on the basis of the following weight composition given as a percentage, with mention of the property generally considered to be the most characteristic. teristic in the context of the present invention:
- Nipasol propyl parahydroxybenzoate 0.07 preservative
- solution B 100 liters of purified water are dissolved and with electric stirring, the sodium rinocleatate, sodium saccharinate and sodium dihydroxyallantoinate, which gives the so-called solution B.
- a sufficient quantity of purified water is introduced into a disperser with the mixture of silica, xylitol, oxy- of titanium and aluminum hydroxide. The mixture is allowed to homogenize. Solution B is then added by filtering and pumping, then boric acid, lauric alcohol sul fane and any chloroform. After a few minutes, solution A is added as well as the fragrance essences in which the preservatives have previously been dissolved. The apparatus is left to rotate until good homogeneity, then the neutral red is incorporated and it is turned until perfect homogeneity, that is to say for about thirty minutes. Then deaerated under vacuum for a quarter of an hour.
- the paste thus obtained is crushed and stored in tanks for 48 hours.
- composition in accordance with the invention can be used as a toothpaste, the dental plaque being, in a first phase, directly colored, here essentially thanks to neutral red, the toothpaste acting in a second phase, removing the staining with all or part of the dental plaque.
- neutral red indicates the pH (red at pH 6.8, yellow at 8.0) and allows the revelation and detection of plaque microorganisms.
- cetylpyridinium chloride associated with neutral red acts as an energetic inhibitor of plaque and dissolves mucins.
- Example 1 is repeated, replacing cetylpyridinium chloride with chlorhexidine and neutral red (Basic Red 5 of the Color Index) with toluidine blue 0 (Basic blue 17 of the Color Index) or methyl violet (Basic Violet of color Index).
- Example 3 We obtain results as satisfactory as in Example 1 and in the case of methyl violet (Example 3) an enhanced action on the microorganisms of the plate.
- Example 3 there are obtained revealing, inhibiting, toothpaste and, with certain dyes, indicating pH compositions.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7920929 | 1979-08-20 | ||
| FR7920929A FR2463613A1 (fr) | 1979-08-20 | 1979-08-20 | Nouvelles compositions pour la revelation de la plaque dentaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0034595A1 true EP0034595A1 (fr) | 1981-09-02 |
Family
ID=9228939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP80901502A Withdrawn EP0034595A1 (fr) | 1979-08-20 | 1981-03-09 | Nouvelles compositions pour la revelation et l'inhibition de la plaque dentaire |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0034595A1 (enExample) |
| JP (1) | JPS57501280A (enExample) |
| AU (1) | AU6223080A (enExample) |
| BE (1) | BE884850A (enExample) |
| FR (1) | FR2463613A1 (enExample) |
| GR (1) | GR82353B (enExample) |
| NO (1) | NO811325L (enExample) |
| OA (1) | OA07365A (enExample) |
| PT (1) | PT71709B (enExample) |
| WO (1) | WO1981000513A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009017090A1 (de) * | 2009-04-15 | 2010-11-11 | Festo Ag & Co. Kg | Verfahren zur Ermittlung von Reglerparametern einer Regelungseinrichtung zur Antriebsregelung eines Antriebssystems |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01246214A (ja) * | 1988-03-28 | 1989-10-02 | Shiseido Co Ltd | 口腔用組成物 |
| FR2791890B1 (fr) * | 1999-04-12 | 2004-12-10 | Gilbert Lab | Solution de chlorhexidine alcoolique coloree et sa methode de fabrication |
| ITMI20011315A1 (it) * | 2001-06-21 | 2002-12-21 | Herbariorum Medicaminum Offici | Composizione per pasta dentifricia antiplacca con rilevatore di placca |
| US20050058602A1 (en) * | 2003-09-11 | 2005-03-17 | The Procter & Gamble Company | Dye composition and method for detection of demineralized lesions in teeth |
| BR122015013776B1 (pt) | 2005-11-09 | 2016-12-06 | Klox Technologies Inc | composição, método para branqueamento de dentes e kit |
| US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| MX337084B (es) | 2008-11-07 | 2016-02-10 | Klox Technologies Inc | Combinacion de un oxidante y un fotoactivador destinada a la cicatrizacion. |
| EP3318274A1 (en) | 2009-07-17 | 2018-05-09 | KLOX Technologies, Inc. | Antibacterial oral composition |
| ES2600316T3 (es) * | 2011-11-15 | 2017-02-08 | Colgate-Palmolive Company | Sistemas distribuidores de gel para la higiene bucodental |
| BR112014011663A2 (pt) * | 2011-11-15 | 2017-05-30 | Colgate Palmolive Co | géis de higiene bucal |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US20140105832A1 (en) | 2012-09-14 | 2014-04-17 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
| US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| KR20210142011A (ko) | 2013-07-03 | 2021-11-23 | 광동 클록스 바이오메디컬 그룹 씨오., 엘티디 | 상처를 치료하기 위한 발색단과 겔화제를 포함하는 생체광자성 조성물 |
| EP3125963B1 (en) | 2014-04-01 | 2019-11-20 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
| AU2015337786B2 (en) | 2014-10-31 | 2020-03-26 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3723613A (en) * | 1971-01-22 | 1973-03-27 | J Derdivanis | Dental plaque disclosing agent |
| AU6703974A (en) * | 1973-03-30 | 1975-09-25 | Selwyn S L | Dental plaque disclosing agents |
| US4080441A (en) * | 1976-12-27 | 1978-03-21 | Colgate-Palmolive Company | Antibacterial oral composition |
-
1979
- 1979-08-20 FR FR7920929A patent/FR2463613A1/fr active Granted
-
1980
- 1980-08-13 WO PCT/FR1980/000131 patent/WO1981000513A1/fr not_active Ceased
- 1980-08-13 JP JP55501817A patent/JPS57501280A/ja active Pending
- 1980-08-13 AU AU62230/80A patent/AU6223080A/en not_active Abandoned
- 1980-08-19 PT PT71709A patent/PT71709B/pt unknown
- 1980-08-20 BE BE0/201807A patent/BE884850A/fr unknown
- 1980-08-20 GR GR62709A patent/GR82353B/el unknown
-
1981
- 1981-03-09 EP EP80901502A patent/EP0034595A1/fr not_active Withdrawn
- 1981-04-15 NO NO811325A patent/NO811325L/no unknown
- 1981-04-20 OA OA57380A patent/OA07365A/xx unknown
Non-Patent Citations (1)
| Title |
|---|
| See references of WO8100513A1 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009017090A1 (de) * | 2009-04-15 | 2010-11-11 | Festo Ag & Co. Kg | Verfahren zur Ermittlung von Reglerparametern einer Regelungseinrichtung zur Antriebsregelung eines Antriebssystems |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1981000513A1 (fr) | 1981-03-05 |
| JPS57501280A (enExample) | 1982-07-22 |
| AU6223080A (en) | 1981-03-18 |
| BE884850A (fr) | 1980-12-16 |
| OA07365A (fr) | 1984-06-30 |
| PT71709B (fr) | 1981-06-17 |
| PT71709A (fr) | 1980-09-01 |
| FR2463613A1 (fr) | 1981-02-27 |
| FR2463613B1 (enExample) | 1983-01-28 |
| GR82353B (enExample) | 1984-12-13 |
| NO811325L (no) | 1981-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| AK | Designated contracting states |
Designated state(s): AT CH DE FR GB LI LU NL SE |
|
| 17P | Request for examination filed |
Effective date: 19810907 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 19840124 |