WO1981000513A1 - Nouvelles compositions pour la revelation et l'inhibition de la plaque dentaire - Google Patents

Nouvelles compositions pour la revelation et l'inhibition de la plaque dentaire Download PDF

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Publication number
WO1981000513A1
WO1981000513A1 PCT/FR1980/000131 FR8000131W WO8100513A1 WO 1981000513 A1 WO1981000513 A1 WO 1981000513A1 FR 8000131 W FR8000131 W FR 8000131W WO 8100513 A1 WO8100513 A1 WO 8100513A1
Authority
WO
WIPO (PCT)
Prior art keywords
dental plaque
compositions according
constituents
compositions
revealing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1980/000131
Other languages
English (en)
French (fr)
Inventor
J Thorel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO1981000513A1 publication Critical patent/WO1981000513A1/fr
Priority to DK175381A priority Critical patent/DK175381A/da
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes

Definitions

  • the present invention relates to new compositions for dental hygiene and treatment having, among other aims, that of revealing and treating dental plaque.
  • a dental plaque denotes a film depositing on the surface of the teeth and which is interposed between the teeth and the oral environment. It is essentially made up of a layer of more or less denatured natural and salivary proteins, salivary mucin and various living or dead microorganisms. Physico-chemically, dental plaque has properties linked to its high protein content. This largely protein film therefore constitutes a barrier between the teeth and the buccal volume in which the free saliva is slightly acidic or substantially neutral (pH 5.6 to 7.6 most generally). It tends to be more acidic at rest than during the active period.
  • the object of the present invention is therefore, when the user so desires, and in particular when he is washing his teeth, to allow him to see appear, thanks to a clear coloration, said dental plaque, coloration then easily eliminated by washing and / or conventional brushing generally carried out using toothpaste.
  • compositions revealing dental plaque in accordance with the invention, only, which requires subsequent elimination, or to use a unique composition including that according to the invention revealing dental plaque by coloring and the constituents of any conventional ifrice tooth.
  • the latter solution being the simplest, we will insist on it in the examples which follow, without this limiting the scope of the invention.
  • compositions according to the present invention therefore contain at least one body hereinafter called a developer which brings to the dental plaque a color which does not appear or appears differently on the other surfaces of the oral cavity.
  • a developer which brings to the dental plaque a color which does not appear or appears differently on the other surfaces of the oral cavity.
  • This staining of dental plaque can be obtained using any product which, in sufficient concentration, fixes physically, chemically and / or biologically, a layer, a film or particles, the time necessary for observation, and can then be easily removed. It is therefore important that the coloration be apparent during this observation, so that it can appear only at the time of contact between developer and dental plaque, by physical, chemical and / or biological interaction between the developers and one or more constituents of dental plaque.
  • compositions having the following properties:
  • a toothpaste is prepared on the basis of the following weight composition given as a percentage, with mention of the property generally considered to be the most characteristic. teristic in the context of the present invention:
  • Nipasol propyl parahydroxybenzoate 0.07 preservative
  • solution B 100 liters of purified water are dissolved and with electric stirring, the sodium rinocleatate, sodium saccharinate and sodium dihydroxyallantoinate, which gives the so-called solution B.
  • a sufficient quantity of purified water is introduced into a disperser with the mixture of silica, xylitol, oxy- of titanium and aluminum hydroxide. The mixture is allowed to homogenize. Solution B is then added by filtering and pumping, then boric acid, lauric alcohol sul fane and any chloroform. After a few minutes, solution A is added as well as the fragrance essences in which the preservatives have previously been dissolved. The apparatus is left to rotate until good homogeneity, then the neutral red is incorporated and it is turned until perfect homogeneity, that is to say for about thirty minutes. Then deaerated under vacuum for a quarter of an hour.
  • the paste thus obtained is crushed and stored in tanks for 48 hours.
  • composition in accordance with the invention can be used as a toothpaste, the dental plaque being, in a first phase, directly colored, here essentially thanks to neutral red, the toothpaste acting in a second phase, removing the staining with all or part of the dental plaque.
  • neutral red indicates the pH (red at pH 6.8, yellow at 8.0) and allows the revelation and detection of plaque microorganisms.
  • cetylpyridinium chloride associated with neutral red acts as an energetic inhibitor of plaque and dissolves mucins.
  • Example 1 is repeated, replacing cetylpyridinium chloride with chlorhexidine and neutral red (Basic Red 5 of the Color Index) with toluidine blue 0 (Basic blue 17 of the Color Index) or methyl violet (Basic Violet of color Index).
  • Example 3 We obtain results as satisfactory as in Example 1 and in the case of methyl violet (Example 3) an enhanced action on the microorganisms of the plate.
  • Example 3 there are obtained revealing, inhibiting, toothpaste and, with certain dyes, indicating pH compositions.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
PCT/FR1980/000131 1979-08-20 1980-08-13 Nouvelles compositions pour la revelation et l'inhibition de la plaque dentaire Ceased WO1981000513A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK175381A DK175381A (da) 1980-08-13 1981-04-15 Praeparater til paavisning og forebyggelse af plak

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7920929 1979-08-20
FR7920929A FR2463613A1 (fr) 1979-08-20 1979-08-20 Nouvelles compositions pour la revelation de la plaque dentaire

Publications (1)

Publication Number Publication Date
WO1981000513A1 true WO1981000513A1 (fr) 1981-03-05

Family

ID=9228939

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1980/000131 Ceased WO1981000513A1 (fr) 1979-08-20 1980-08-13 Nouvelles compositions pour la revelation et l'inhibition de la plaque dentaire

Country Status (10)

Country Link
EP (1) EP0034595A1 (enExample)
JP (1) JPS57501280A (enExample)
AU (1) AU6223080A (enExample)
BE (1) BE884850A (enExample)
FR (1) FR2463613A1 (enExample)
GR (1) GR82353B (enExample)
NO (1) NO811325L (enExample)
OA (1) OA07365A (enExample)
PT (1) PT71709B (enExample)
WO (1) WO1981000513A1 (enExample)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2791890A1 (fr) * 1999-04-12 2000-10-13 Gilbert Lab Solution de chlorhexidine alcoolique coloree et sa methode de fabrication
US8632822B2 (en) 2008-11-07 2014-01-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8685466B2 (en) 2009-07-17 2014-04-01 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US8986719B2 (en) 2005-11-09 2015-03-24 Klox Technologies Inc. Teeth whitening compositions and methods
US9345648B2 (en) 2006-11-09 2016-05-24 Klox Technologies Inc. Photoactivatable oxygen-evolving compositions and methods for teeth whitening
US9655829B2 (en) 2012-09-14 2017-05-23 Valeant Pharmaceuticals International, Inc. Compositions and methods for teeth whitening
US10130706B2 (en) 2013-03-14 2018-11-20 Klox Technologies Inc. Biophotonic materials and uses thereof
US10207029B2 (en) 2014-04-01 2019-02-19 Klox Technologies Inc. Tissue filler compositions and methods of use
US10213373B2 (en) 2012-04-20 2019-02-26 Klox Technologies, Inc. Chromophore combinations for biophotonic uses
US10881736B2 (en) 2013-07-03 2021-01-05 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US11421349B2 (en) 2014-10-31 2022-08-23 Klox Technologies Inc. Photoactivatable fibers and fabric media
RU2815420C1 (ru) * 2022-12-23 2024-03-14 Общество с ограниченной ответственностью "Эрин Хайден Рус" Гель-индикатор для визуализации зубного налета и биопленки на зубах и способ его изготовления

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01246214A (ja) * 1988-03-28 1989-10-02 Shiseido Co Ltd 口腔用組成物
ITMI20011315A1 (it) * 2001-06-21 2002-12-21 Herbariorum Medicaminum Offici Composizione per pasta dentifricia antiplacca con rilevatore di placca
US20050058602A1 (en) * 2003-09-11 2005-03-17 The Procter & Gamble Company Dye composition and method for detection of demineralized lesions in teeth
DE102009017090A1 (de) * 2009-04-15 2010-11-11 Festo Ag & Co. Kg Verfahren zur Ermittlung von Reglerparametern einer Regelungseinrichtung zur Antriebsregelung eines Antriebssystems
ES2600316T3 (es) * 2011-11-15 2017-02-08 Colgate-Palmolive Company Sistemas distribuidores de gel para la higiene bucodental
BR112014011663A2 (pt) * 2011-11-15 2017-05-30 Colgate Palmolive Co géis de higiene bucal

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723613A (en) * 1971-01-22 1973-03-27 J Derdivanis Dental plaque disclosing agent
DE2415093A1 (de) * 1973-03-30 1974-10-17 Stephen Leigh Selwyn Zahnbelag-erkennungsmittel
US4080441A (en) * 1976-12-27 1978-03-21 Colgate-Palmolive Company Antibacterial oral composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723613A (en) * 1971-01-22 1973-03-27 J Derdivanis Dental plaque disclosing agent
DE2415093A1 (de) * 1973-03-30 1974-10-17 Stephen Leigh Selwyn Zahnbelag-erkennungsmittel
US4080441A (en) * 1976-12-27 1978-03-21 Colgate-Palmolive Company Antibacterial oral composition

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044686A1 (fr) * 1999-04-12 2000-10-18 Laboratoires Gilbert SA Solution de chlorhexidine alcoolique colorée et sa méthode de fabrication
FR2791890A1 (fr) * 1999-04-12 2000-10-13 Gilbert Lab Solution de chlorhexidine alcoolique coloree et sa methode de fabrication
US8986719B2 (en) 2005-11-09 2015-03-24 Klox Technologies Inc. Teeth whitening compositions and methods
US9345648B2 (en) 2006-11-09 2016-05-24 Klox Technologies Inc. Photoactivatable oxygen-evolving compositions and methods for teeth whitening
US10485986B2 (en) 2008-11-07 2019-11-26 Klox Technologies Inc. Methods and compositions for treatment of pigmented lesions
US9597349B2 (en) 2008-11-07 2017-03-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8911791B2 (en) 2008-11-07 2014-12-16 Klox Technologies Inc. Method for acne treatment using an oxidative-photoactivated composition
US8974833B2 (en) 2008-11-07 2015-03-10 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8986745B2 (en) 2008-11-07 2015-03-24 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US8658219B2 (en) 2008-11-07 2014-02-25 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US10384072B2 (en) 2008-11-07 2019-08-20 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8637086B2 (en) 2008-11-07 2014-01-28 Klox Technologies Inc. Method for acne treatment using an oxidative-photoactivated composition
US9375446B2 (en) 2008-11-07 2016-06-28 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US11691025B2 (en) 2008-11-07 2023-07-04 Klox Technologies Inc. Methods and compositions for reversing or mitigating skin aging
US10758744B2 (en) 2008-11-07 2020-09-01 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the wounds
US8632822B2 (en) 2008-11-07 2014-01-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US11020609B2 (en) 2008-11-07 2021-06-01 Klox Technologies Inc. Methods and compositions for treatment of pigmented lesions
US10149985B2 (en) 2008-11-07 2018-12-11 Klox Technologies Inc. Methods and compositions for treating rosacea
US11141482B2 (en) 2009-07-17 2021-10-12 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US8685466B2 (en) 2009-07-17 2014-04-01 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10322179B2 (en) 2009-07-17 2019-06-18 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US9603929B2 (en) 2009-07-17 2017-03-28 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfecton and treatment of oral disease
US8986746B2 (en) 2009-07-17 2015-03-24 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10471147B2 (en) 2009-07-17 2019-11-12 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10213373B2 (en) 2012-04-20 2019-02-26 Klox Technologies, Inc. Chromophore combinations for biophotonic uses
US10376455B2 (en) 2012-04-20 2019-08-13 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US11723854B2 (en) 2012-04-20 2023-08-15 Fle International S.R.L. Biophotonic compositions and methods for providing biophotonic treatment
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US11331257B2 (en) 2012-04-20 2022-05-17 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US9655829B2 (en) 2012-09-14 2017-05-23 Valeant Pharmaceuticals International, Inc. Compositions and methods for teeth whitening
US12496344B2 (en) 2013-03-14 2025-12-16 Fle International S.R.L. Biophotonic materials and uses thereof
US10130706B2 (en) 2013-03-14 2018-11-20 Klox Technologies Inc. Biophotonic materials and uses thereof
US11324823B2 (en) 2013-03-14 2022-05-10 Klox Technologies Inc. Biophotonic materials and uses thereof
US10881736B2 (en) 2013-07-03 2021-01-05 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
US10772990B2 (en) 2014-04-01 2020-09-15 Klox Technologies Inc. Tissue filler compositions and methods of use
US10207029B2 (en) 2014-04-01 2019-02-19 Klox Technologies Inc. Tissue filler compositions and methods of use
US11421349B2 (en) 2014-10-31 2022-08-23 Klox Technologies Inc. Photoactivatable fibers and fabric media
RU2815420C1 (ru) * 2022-12-23 2024-03-14 Общество с ограниченной ответственностью "Эрин Хайден Рус" Гель-индикатор для визуализации зубного налета и биопленки на зубах и способ его изготовления

Also Published As

Publication number Publication date
JPS57501280A (enExample) 1982-07-22
AU6223080A (en) 1981-03-18
BE884850A (fr) 1980-12-16
OA07365A (fr) 1984-06-30
PT71709B (fr) 1981-06-17
EP0034595A1 (fr) 1981-09-02
PT71709A (fr) 1980-09-01
FR2463613A1 (fr) 1981-02-27
FR2463613B1 (enExample) 1983-01-28
GR82353B (enExample) 1984-12-13
NO811325L (no) 1981-04-15

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