EP0028411A1 - Bouchon pour flacons - Google Patents

Bouchon pour flacons Download PDF

Info

Publication number
EP0028411A1
EP0028411A1 EP80106715A EP80106715A EP0028411A1 EP 0028411 A1 EP0028411 A1 EP 0028411A1 EP 80106715 A EP80106715 A EP 80106715A EP 80106715 A EP80106715 A EP 80106715A EP 0028411 A1 EP0028411 A1 EP 0028411A1
Authority
EP
European Patent Office
Prior art keywords
flange
stopper
inner cap
rubber plug
cap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP80106715A
Other languages
German (de)
English (en)
Other versions
EP0028411B1 (fr
Inventor
Hisatomi Fukuoka
Seizou Sunago
Kiyonori Okada
Shinji Nakashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to AT80106715T priority Critical patent/ATE5958T1/de
Publication of EP0028411A1 publication Critical patent/EP0028411A1/fr
Application granted granted Critical
Publication of EP0028411B1 publication Critical patent/EP0028411B1/fr
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/241—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means

Definitions

  • This invention relates to a stopper for vials, and more particularly to a stopper for sealing off a vial by a simplified procedure without necessitating the step of crimping an aluminum cap.
  • Subject matter of this invention therefore is a stopper for a vial having a flange at its opening portion, characterized by a rubber plug having a top plate fittable to the flange in pressing contact therewith, a flexible inner cap for receiving the rubber plug therein and an outer cap fittable over the inner cap, the inner cap having an upper wall formed with a hole in its center and a side wall formed with at least one projection on the inner peripheral surface thereof, the projection being fittable to the lower face of the flange with the top plate of the rubber plug held between the upper wall and the flange.
  • the stopper of this invention comprises an outer cap 1, an inner cap 2 and a rubber plug 3.
  • the outer cap 1 includes an upper wlal la and a side wall 1b integral therewith and formed with a projection 4 on its inner peripheral surface.
  • the projection 4 is engageable with the outer periphery of the side wall 2b of the inner cap 2 to hold the outer cap 1 thereon.
  • the inner cap 2 includes an upper wall 2a integral with the above-mentioned side wall 2b.
  • the upper wall 2a is formed in its center with a hole 5 for permitting an injection needle to penetrate the rubber plug 3.
  • Formed on the inner periheral surface of the side wall 2b are two projections 6 which are fittable to the lower face of the flange 11a of a vial 11 with the top plate 3a of the rubber plug 3 positioned between the upper wall 2a and the flange 11a.
  • Four projections 7 are provided on the inner surface of the side wall 2b at its upper end for engaging the top plate 3a of the rubber plug 3 to retain the plug 3 in the inner cap 2.
  • the rubber plug 3 which is a rubber stopper heretofore used for vials, comprises the above-mentioned top plate 3a serving as a packing, and two legs 3b. Each of the legs has on its outer surface a projection 8 engageable with the opening portion of the vial 11.
  • the outer cap 1 and the inner cap 2 are made of a flexible plastic, which is preferably polypropylene, polyethylene, polycarbonate or the like.
  • the projection 4 on the outer cap 1 and the projections 6 and 7 on the inner cap 2 are not limitative in their arrangement but can be provided as desired insofar as they are serviceable as contemplated.
  • the projections 6 on the inner cap 2 may be in the form of a continuous projection extending over the entire inner periphery of the inner cap side wall 2b like the projection 4 on the outer cap 1, or may be in the form of dots resembling the projections 7 on the inner cap 2.
  • the stopper of this invention will be used in the following manner, for example, for a vial 11 for containing a freeze-dried preparation for injection.
  • the inner cap 2 is fitted in the outer cap 1 in engagement with the projection 4, with the rubber plug 3 engaged with the projections 7 on the inner cap 2.
  • the vial stopper of this invention for which no aluminum material is used, can be manufactured at a low cost.
  • the stopper is easy to use since it seals off the vial completely when simply pressed on. Because the sealing step can be performed subsequent to freeze-drying within a freeze-drying chamber in a continuous operation, the stopper is very useful for providing pharmaceutical products free from foreign matter and having an extremely low water content and a high quality.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP80106715A 1979-11-01 1980-10-31 Bouchon pour flacons Expired EP0028411B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT80106715T ATE5958T1 (de) 1979-11-01 1980-10-31 Stopfen fuer flaeschchen.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP142612/79 1979-11-01
JP14261279A JPS5664961A (en) 1979-11-01 1979-11-01 Plug body for vial

Publications (2)

Publication Number Publication Date
EP0028411A1 true EP0028411A1 (fr) 1981-05-13
EP0028411B1 EP0028411B1 (fr) 1984-01-25

Family

ID=15319368

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80106715A Expired EP0028411B1 (fr) 1979-11-01 1980-10-31 Bouchon pour flacons

Country Status (5)

Country Link
EP (1) EP0028411B1 (fr)
JP (1) JPS5664961A (fr)
AT (1) ATE5958T1 (fr)
DE (1) DE3066308D1 (fr)
ES (1) ES265665Y (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3241283A1 (de) * 1981-11-13 1983-05-19 Manufacture Lyonnaise de Bouchage, 69008 Lyon Verschluss fuer behaelter beinhaltend ein injektionsgut
US4465200A (en) * 1983-06-06 1984-08-14 Becton, Dickinson And Company Low contamination closure for blood collection tubes
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
EP0257498A2 (fr) * 1986-08-18 1988-03-02 Becton, Dickinson and Company Bouchon composite caoutchouc-plastique muni de joints mécaniques adhésifs
WO1991011259A1 (fr) * 1990-01-26 1991-08-08 Mallinckrodt, Inc. Systeme d'echantillonnage hygienique
US5232111A (en) * 1991-05-13 1993-08-03 Becton, Dickinson And Company Stopper-shield combination closure
GB2312207A (en) * 1996-10-25 1997-10-22 Massmould Holdings Cap and plug closure assembly
FR2753180A1 (fr) * 1996-09-12 1998-03-13 Comar Inc Ensemble formant capuchon pour flacon a goulot en forme d'engrenage
US5823379A (en) * 1993-10-20 1998-10-20 Amersham International Plc Sealed container for hazardous material
WO2006066056A2 (fr) * 2004-12-16 2006-06-22 Dade Behring Inc. Bouchon de flacon d'etalonnage presentant des caracteristiques de securite ameliorees
US7543188B2 (en) * 2005-06-29 2009-06-02 Oracle International Corp. Browser based remote control of functional testing tool
JP2010517885A (ja) * 2007-02-09 2010-05-27 バイオコープ ルシェルシュ エ ディベロプメント 容器を固定するための装置、当該装置を備える容器及び当該容器のバッチを閉鎖するための方法
WO2013068636A1 (fr) * 2011-10-28 2013-05-16 Thermo Fisher Scientific Oy Flacon à réactif, système, procédé et appareil de manipulation de bouchons de fermeture et similaires
WO2019125223A1 (fr) * 2017-12-21 2019-06-27 Акционерное общество "Елатомский приборный завод" Tube à essai sous vide

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6096260U (ja) * 1983-12-05 1985-07-01 第一製薬株式会社 薬用壜の蓋
JPS61178344U (fr) * 1985-04-24 1986-11-07
JPS63180556U (fr) * 1987-05-12 1988-11-22
EP0819617B1 (fr) 1995-10-18 2001-01-31 Daikyo Seiko, Ltd. Capuchon en plastique et son procédé de fabrication
JP5479029B2 (ja) * 2009-10-30 2014-04-23 株式会社大協精工 バイアル用のゴム栓（ｂ）とプラスチック製キャップ（ｃ）との組み合わせ
JP5683129B2 (ja) * 2010-04-30 2015-03-11 大和特殊硝子株式会社 バイアル用栓体とこれに用いるシール部材

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1949902A (en) * 1930-11-05 1934-03-06 Owens Illinois Glass Co Bottle closure
US3073471A (en) * 1960-03-17 1963-01-15 Aluminum Co Of America Closure device for sealed packages
US3092278A (en) * 1957-09-20 1963-06-04 Astra Apotekarnes Kem Fab Cap for a container for an injection liquid
US3746196A (en) * 1971-01-29 1973-07-17 Green Cross Corp Coated plastic container for liquid medicine
DE2361350B1 (de) * 1973-12-08 1975-05-28 Matthias Faensen, Kleinmetallwarenfabrikation, 5190 Stolberg Verschluß für pharmazeutische Flaschen
DE1946566B2 (de) * 1969-09-13 1975-07-10 Pharma-Gummi Wimmer West Gmbh, 5180 Eschweiler Flaschenverschluß mit einem durchstechbaren Verschlußkörper zur Entnahme von Medikamenten
DE2405169A1 (de) * 1974-02-04 1975-08-07 Sanner Kg Friedr Tropfeinsatz
GB1406776A (en) * 1972-02-22 1975-09-17 Baxter Laboratories Inc Closure device especially for parenteral solution bottles
DE2734846A1 (de) * 1976-08-03 1978-02-09 Abbott Lab Einteiliger geschlossener kunststoffbehaelter fuer sterile fluessigkeiten
EP0006032A1 (fr) * 1978-06-05 1979-12-12 Merck & Co. Inc. Récipient à bouchon inviolable

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888377A (en) * 1973-05-30 1975-06-10 Reinhard Stadler Closure cap for an infusion flask

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1949902A (en) * 1930-11-05 1934-03-06 Owens Illinois Glass Co Bottle closure
US3092278A (en) * 1957-09-20 1963-06-04 Astra Apotekarnes Kem Fab Cap for a container for an injection liquid
US3073471A (en) * 1960-03-17 1963-01-15 Aluminum Co Of America Closure device for sealed packages
DE1946566B2 (de) * 1969-09-13 1975-07-10 Pharma-Gummi Wimmer West Gmbh, 5180 Eschweiler Flaschenverschluß mit einem durchstechbaren Verschlußkörper zur Entnahme von Medikamenten
US3746196A (en) * 1971-01-29 1973-07-17 Green Cross Corp Coated plastic container for liquid medicine
GB1406776A (en) * 1972-02-22 1975-09-17 Baxter Laboratories Inc Closure device especially for parenteral solution bottles
DE2361350B1 (de) * 1973-12-08 1975-05-28 Matthias Faensen, Kleinmetallwarenfabrikation, 5190 Stolberg Verschluß für pharmazeutische Flaschen
DE2405169A1 (de) * 1974-02-04 1975-08-07 Sanner Kg Friedr Tropfeinsatz
DE2734846A1 (de) * 1976-08-03 1978-02-09 Abbott Lab Einteiliger geschlossener kunststoffbehaelter fuer sterile fluessigkeiten
EP0006032A1 (fr) * 1978-06-05 1979-12-12 Merck & Co. Inc. Récipient à bouchon inviolable

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3241283A1 (de) * 1981-11-13 1983-05-19 Manufacture Lyonnaise de Bouchage, 69008 Lyon Verschluss fuer behaelter beinhaltend ein injektionsgut
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
US4465200A (en) * 1983-06-06 1984-08-14 Becton, Dickinson And Company Low contamination closure for blood collection tubes
EP0129029A1 (fr) * 1983-06-06 1984-12-27 Becton Dickinson and Company Bouchon pour tubes de prélèvement de sang évitant la contamination
EP0257498A2 (fr) * 1986-08-18 1988-03-02 Becton, Dickinson and Company Bouchon composite caoutchouc-plastique muni de joints mécaniques adhésifs
EP0257498A3 (en) * 1986-08-18 1988-08-03 Becton, Dickinson And Company Rubber/plastic stopper composite with mechanical adhesive joints
WO1991011259A1 (fr) * 1990-01-26 1991-08-08 Mallinckrodt, Inc. Systeme d'echantillonnage hygienique
US5232111A (en) * 1991-05-13 1993-08-03 Becton, Dickinson And Company Stopper-shield combination closure
US5823379A (en) * 1993-10-20 1998-10-20 Amersham International Plc Sealed container for hazardous material
FR2753180A1 (fr) * 1996-09-12 1998-03-13 Comar Inc Ensemble formant capuchon pour flacon a goulot en forme d'engrenage
GB2312207A (en) * 1996-10-25 1997-10-22 Massmould Holdings Cap and plug closure assembly
GB2312207B (en) * 1996-10-25 1998-08-26 Massmould Holdings Plug closure assembly
WO2006066056A2 (fr) * 2004-12-16 2006-06-22 Dade Behring Inc. Bouchon de flacon d'etalonnage presentant des caracteristiques de securite ameliorees
WO2006066056A3 (fr) * 2004-12-16 2006-10-19 Dade Behring Inc Bouchon de flacon d'etalonnage presentant des caracteristiques de securite ameliorees
US7543188B2 (en) * 2005-06-29 2009-06-02 Oracle International Corp. Browser based remote control of functional testing tool
JP2010517885A (ja) * 2007-02-09 2010-05-27 バイオコープ ルシェルシュ エ ディベロプメント 容器を固定するための装置、当該装置を備える容器及び当該容器のバッチを閉鎖するための方法
WO2013068636A1 (fr) * 2011-10-28 2013-05-16 Thermo Fisher Scientific Oy Flacon à réactif, système, procédé et appareil de manipulation de bouchons de fermeture et similaires
US10335792B2 (en) 2011-10-28 2019-07-02 Thermo Fisher Scientific Oy Reagent bottle cap, system, method and apparatus for handling closure caps and like
WO2019125223A1 (fr) * 2017-12-21 2019-06-27 Акционерное общество "Елатомский приборный завод" Tube à essai sous vide

Also Published As

Publication number Publication date
DE3066308D1 (en) 1984-03-01
ATE5958T1 (de) 1984-02-15
ES265665U (es) 1983-02-01
ES265665Y (es) 1983-07-16
EP0028411B1 (fr) 1984-01-25
JPS5664961A (en) 1981-06-02

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