EP0024313B1 - Verfahren zur rückstandsfreien Dosierung kleiner Flüssigkeitsmengen - Google Patents

Verfahren zur rückstandsfreien Dosierung kleiner Flüssigkeitsmengen Download PDF

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Publication number
EP0024313B1
EP0024313B1 EP80104407A EP80104407A EP0024313B1 EP 0024313 B1 EP0024313 B1 EP 0024313B1 EP 80104407 A EP80104407 A EP 80104407A EP 80104407 A EP80104407 A EP 80104407A EP 0024313 B1 EP0024313 B1 EP 0024313B1
Authority
EP
European Patent Office
Prior art keywords
cylinder
piston
liquid
valve
dead centre
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP80104407A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0024313A1 (de
Inventor
Bernd Dr. Zierenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Priority to AT80104407T priority Critical patent/ATE4290T1/de
Publication of EP0024313A1 publication Critical patent/EP0024313A1/de
Application granted granted Critical
Publication of EP0024313B1 publication Critical patent/EP0024313B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0203—Burettes, i.e. for withdrawing and redistributing liquids through different conduits
    • B01L3/0206—Burettes, i.e. for withdrawing and redistributing liquids through different conduits of the plunger pump type
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B7/00—Piston machines or pumps characterised by having positively-driven valving
    • F04B7/0003—Piston machines or pumps characterised by having positively-driven valving the distribution member forming both the inlet and discharge distributor for one single pumping chamber
    • F04B7/0015—Piston machines or pumps characterised by having positively-driven valving the distribution member forming both the inlet and discharge distributor for one single pumping chamber and having a slidable movement

Definitions

  • the invention relates to a method for residue-free metering of small amounts of liquid by means of a micro-piston pump which has a capillary cylinder in which a gas-tightly fitted piston is movably arranged between an upper and a lower dead center, the cylinder opening into a two-way valve at its end opposite the piston head which alternately connects the cylinder cavity with an inlet and an outlet (which establishes the connection between the cylinder and atmosphere during the 1st stage of the intake process), characterized in that the piston and the valve are moved such that a defined one is initially defined during the intake process Amount of air and then a defined amount of liquid is transported into the cylinder, the amount of air being such that when the piston moves down to bottom dead center, the liquid is discharged through the outlet line without residue.
  • the method can be used with advantage, for example, to supply a defined amount of medicinal substance to the atomizing plate of a piezoelectric atomizer (e.g. according to DE-A-2 537 765).
  • the pump according to DE-C-254111 which is of larger dimensions, neither has the capillarity of the pump cylinder nor is the use of air provided as an aid for complete emptying when it is actuated.
  • the micro-piston pump that can be used according to the invention essentially consists of a capillary-like cylinder with a gas-tightly fitted piston, a two-way valve with inlet and outlet at the end of the cylinder opposite the piston head, and possibly a control device that coordinates the piston movement and valve setting.
  • FIGS. 1 and 2 A typical embodiment of the micro-piston pump that can be used according to the invention is shown in FIGS. 1 and 2, with FIG. 1 showing the micro-piston pump in the initial state and FIG. 2 the micro-piston pump in the filled state.
  • FIG. 3 A vertical section through the middle of the lower part of the micro-piston pump, perpendicular to the section shown in FIG. 1, is shown in FIG. 3.
  • the cylinder 2 ends in a valve block 4, e.g. B. from a plastic 3, such as Teflon®, in which the gas-tight valve, preferably made of stainless steel valve slide 5 each up to the stop 6; 7 can be moved.
  • a plastic 3 such as Teflon®
  • the position of the constriction 8 of the valve spool 5 relative to the inlet 9 or outlet 10 results in a connection between the inlet or outlet and the cavity 11 of the cylinder.
  • the piston 1 is at its bottom dead center when the piston handle 12 abuts the cylinder.
  • the product of the clear cross-section of the cylinder and the stroke between marks a and c determines the dosage.
  • the micro-piston pump that can be used according to the invention is preferably used for metering liquid quantities in the range from 10 to 50 ⁇ l, but can also be set up for larger or smaller volumes by changing the dimensions.
  • the use of a sufficiently narrow cylinder ensures that the filled microcol the air column between the piston and the liquid is retained.
  • a simple device for this purpose consists of a combination of gears, racks and levers, which is constructed as follows:
  • gears are arranged side by side and rigidly connected to each other.
  • the circumference of the gears is only partially covered with teeth, in such a way that only one gear becomes effective at a certain point in time.
  • the first gearwheel effects the process a) via a rack and lever
  • the other three run freely until the desired amount of air has entered the cylinder.
  • the second gear ensures the adjustment of the valve spool, while at the same time the first gear moves the piston towards top dead center.
  • gear 1 runs freely, a third gear brings the valve spool into the outlet position.
  • the fourth gear with the associated transmission elements takes over to move the piston to the bottom dead center.
  • the control mechanism is designed so that after rotating the gearwheels through 360 °, all elements are in the starting position again.
  • the rotary movement is replaced by an up and down movement.

Landscapes

  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Reciprocating Pumps (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Volume Flow (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Details Of Reciprocating Pumps (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP80104407A 1979-08-20 1980-07-26 Verfahren zur rückstandsfreien Dosierung kleiner Flüssigkeitsmengen Expired EP0024313B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT80104407T ATE4290T1 (de) 1979-08-20 1980-07-26 Verfahren zur rueckstandsfreien dosierung kleiner fluessigkeitsmengen.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792933617 DE2933617A1 (de) 1979-08-20 1979-08-20 Mikrokolbenpumpe
DE2933617 1979-08-20

Publications (2)

Publication Number Publication Date
EP0024313A1 EP0024313A1 (de) 1981-03-04
EP0024313B1 true EP0024313B1 (de) 1983-07-27

Family

ID=6078839

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80104407A Expired EP0024313B1 (de) 1979-08-20 1980-07-26 Verfahren zur rückstandsfreien Dosierung kleiner Flüssigkeitsmengen

Country Status (14)

Country Link
EP (1) EP0024313B1 (fi)
JP (1) JPS5632082A (fi)
AT (1) ATE4290T1 (fi)
AU (1) AU544213B2 (fi)
CA (1) CA1152379A (fi)
DE (2) DE2933617A1 (fi)
DK (1) DK147844C (fi)
ES (1) ES494358A0 (fi)
FI (1) FI67434C (fi)
IE (1) IE50187B1 (fi)
IL (1) IL60854A0 (fi)
NO (1) NO155358C (fi)
NZ (1) NZ194707A (fi)
ZA (1) ZA805103B (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6520755B1 (en) * 2000-10-10 2003-02-18 Beckman Coulter, Inc. Fluid-moving device with integrated valve
CN109573124A (zh) * 2018-12-29 2019-04-05 河南官渡生物工程有限公司 用于兽药生产的可调节灌装量的柱塞泵

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE125606C (fi) *
DE254111C (fi) *
GB1109492A (en) * 1964-04-29 1968-04-10 Snam Spa Improvements in or relating to hydraulic reciprocating pumps
JPS4935904A (fi) * 1972-08-09 1974-04-03
FR2319117A1 (fr) * 1975-07-25 1977-02-18 Pasteur Institut Dispositif pour prelever et/ou delivrer de faibles quantites dosees de liquide
US4022065A (en) * 1976-02-19 1977-05-10 Ramin James A Calibrated sample delivery apparatus accommodating offset error
US4061037A (en) * 1976-09-20 1977-12-06 Keegan William P Pipettes
US4091677A (en) * 1976-12-23 1978-05-30 Nichiryo Co., Ltd. Pipetting apparatus
JPS541422A (en) * 1977-06-06 1979-01-08 Citizen Watch Co Ltd Fixed quantity of liquid supplying device

Also Published As

Publication number Publication date
NO155358C (no) 1987-03-18
CA1152379A (en) 1983-08-23
IL60854A0 (en) 1980-10-26
NO802439L (no) 1981-02-23
ES8105829A1 (es) 1981-06-16
DK356980A (da) 1981-02-21
ZA805103B (en) 1982-04-28
FI67434C (fi) 1985-03-11
NZ194707A (en) 1984-11-09
IE50187B1 (en) 1986-03-05
AU544213B2 (en) 1985-05-23
ES494358A0 (es) 1981-06-16
DK147844C (da) 1985-06-03
IE801752L (en) 1981-02-20
ATE4290T1 (de) 1983-08-15
NO155358B (no) 1986-12-08
FI67434B (fi) 1984-11-30
AU6156880A (en) 1981-04-09
DE2933617A1 (de) 1981-03-26
JPS5632082A (en) 1981-04-01
DK147844B (da) 1984-12-24
DE3064407D1 (en) 1983-09-01
FI802588A (fi) 1981-02-21
EP0024313A1 (de) 1981-03-04

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