EP0019807A1 - Récipient pour la récupération stérile de solutions de préparations médicamenteuses - Google Patents

Récipient pour la récupération stérile de solutions de préparations médicamenteuses Download PDF

Info

Publication number
EP0019807A1
EP0019807A1 EP80102702A EP80102702A EP0019807A1 EP 0019807 A1 EP0019807 A1 EP 0019807A1 EP 80102702 A EP80102702 A EP 80102702A EP 80102702 A EP80102702 A EP 80102702A EP 0019807 A1 EP0019807 A1 EP 0019807A1
Authority
EP
European Patent Office
Prior art keywords
container
contamination
solutions
removal
taken
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP80102702A
Other languages
German (de)
English (en)
Inventor
Bernd Dr. Zierenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of EP0019807A1 publication Critical patent/EP0019807A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J9/00—Feeding-bottles in general
    • A61J9/001—Feeding-bottles in general with inner liners

Definitions

  • the volume removed When removing liquid from a container, the volume removed must be replaced by an appropriate volume of air.
  • the air access In the case of drug solutions which have to be removed from a storage container in small volumes over a long period of time, the air access has disadvantages. Drugs that are sensitive to oxidation are oxidized by the oxygen, the germs in the air contaminate the drug solution.
  • the negative pressure that arises in the container means that the volumes removed from the storage container by means of metering devices (e.g. peristaltic pumps) become smaller, so that exact metering is no longer possible.
  • metering devices e.g. peristaltic pumps
  • the container according to the invention for the contamination-free removal of drug solutions is characterized in that it consists of a rigid outer container into which air can flow during removal and a flexible, airtightly sealed container connected to it, in which the drug solution is located .
  • the flexible container is generally so large that it completely fills the rigid container and is appropriately provided with a piercing plug.
  • the outer container is preferably also airtight until use, but has a small bore which is made with an easily removable material, e.g. an adhesive strip until it is sealed before use.
  • Plastic bags which can be safely used to store the drug solution, are particularly suitable as material for the inner container.
  • the outer container can consist of any sufficiently rigid material, for example glass, metal, plastic.
  • a standard 20 ml glass injection bottle with a 0.5 mm diameter bore serves as the outer container; the hole is sealed with an airtight adhesive strip until the drug solution is used.
  • a polyethylene bag with a wall thickness of 45 ⁇ m is inserted into the injection vial. After filling with the drug solution, the container is crimped with a piercing rubber stopper.
  • the container was emptied into single doses via a cannula inserted into the crimping plug.
  • the evaluation of the weights of the removed volumes showed no dependence on the degree of emptying.
  • the drug solution could be removed except for a residual amount of less than 1%.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
EP80102702A 1979-05-30 1980-05-16 Récipient pour la récupération stérile de solutions de préparations médicamenteuses Withdrawn EP0019807A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2921960 1979-05-30
DE2921960 1979-05-30

Publications (1)

Publication Number Publication Date
EP0019807A1 true EP0019807A1 (fr) 1980-12-10

Family

ID=6072048

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80102702A Withdrawn EP0019807A1 (fr) 1979-05-30 1980-05-16 Récipient pour la récupération stérile de solutions de préparations médicamenteuses

Country Status (8)

Country Link
EP (1) EP0019807A1 (fr)
JP (1) JPS5618875A (fr)
AU (1) AU5888180A (fr)
DK (1) DK232480A (fr)
FI (1) FI801719A (fr)
IL (1) IL60180A0 (fr)
NO (1) NO801598L (fr)
ZA (1) ZA803246B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034080A (en) * 1987-10-15 1991-07-23 Impact International Pty. Ltd. Method of making a laminated tubular body
US5409559A (en) * 1992-05-20 1995-04-25 Impact International Pty Ltd. Making a laminated tubular body

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2310530A1 (de) * 1972-03-22 1973-09-27 Sulzer Ag Doppelwand-infusionsflasche
DE2433643A1 (de) * 1974-07-12 1976-01-29 Pfrimmer & Co J Zweikammerbehaelter fuer pharmazeutische loesungen
DE2612518A1 (de) * 1975-03-31 1976-10-14 Baxter Laboratories Inc Doppelkammer-behaelter, insbesondere fuer blut o.dgl.
CH610271A5 (en) * 1975-03-04 1979-04-12 Smith & Nephew Pharma Package in which a vessel containing a fluid is arranged in an envelope

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2310530A1 (de) * 1972-03-22 1973-09-27 Sulzer Ag Doppelwand-infusionsflasche
DE2433643A1 (de) * 1974-07-12 1976-01-29 Pfrimmer & Co J Zweikammerbehaelter fuer pharmazeutische loesungen
CH610271A5 (en) * 1975-03-04 1979-04-12 Smith & Nephew Pharma Package in which a vessel containing a fluid is arranged in an envelope
DE2612518A1 (de) * 1975-03-31 1976-10-14 Baxter Laboratories Inc Doppelkammer-behaelter, insbesondere fuer blut o.dgl.

Also Published As

Publication number Publication date
AU5888180A (en) 1980-12-04
IL60180A0 (en) 1980-07-31
DK232480A (da) 1980-12-01
FI801719A (fi) 1980-12-01
ZA803246B (en) 1982-02-24
JPS5618875A (en) 1981-02-23
NO801598L (no) 1980-12-01

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed
AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LU NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19810819

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZIERENBERG, BERND, DR.