EG17149A - Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine - Google Patents

Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine

Info

Publication number
EG17149A
EG17149A EG545/85A EG54585A EG17149A EG 17149 A EG17149 A EG 17149A EG 545/85 A EG545/85 A EG 545/85A EG 54585 A EG54585 A EG 54585A EG 17149 A EG17149 A EG 17149A
Authority
EG
Egypt
Prior art keywords
benzazepine
tetrahydro
chloro
methyl
preparing
Prior art date
Application number
EG545/85A
Other languages
English (en)
Inventor
John Borowski Stanly
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Application granted granted Critical
Publication of EG17149A publication Critical patent/EG17149A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
EG545/85A 1984-09-05 1985-09-04 Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine EG17149A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (1)

Publication Number Publication Date
EG17149A true EG17149A (en) 1989-06-30

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
EG545/85A EG17149A (en) 1984-09-05 1985-09-04 Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine

Country Status (19)

Country Link
US (1) US4541954A (en:Method)
EP (1) EP0174118A3 (en:Method)
JP (1) JPS6168469A (en:Method)
KR (1) KR860002470A (en:Method)
AU (1) AU581918B2 (en:Method)
CA (1) CA1244017A (en:Method)
DK (1) DK379985A (en:Method)
EG (1) EG17149A (en:Method)
ES (1) ES8609266A1 (en:Method)
FI (1) FI853255A7 (en:Method)
GR (1) GR852041B (en:Method)
HU (1) HU194181B (en:Method)
IL (1) IL76100A0 (en:Method)
NO (1) NO853255L (en:Method)
NZ (1) NZ213141A (en:Method)
PH (1) PH20796A (en:Method)
PT (1) PT81018B (en:Method)
ZA (1) ZA856268B (en:Method)
ZW (1) ZW13385A1 (en:Method)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
DE69218587T2 (de) * 1991-12-06 1997-08-14 Yuasa Battery Co Ltd Dünne batterie und monolitische dünne batterie
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US8367657B2 (en) * 2003-06-17 2013-02-05 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
MXPA05013366A (es) 2003-06-17 2006-04-05 Arena Pharm Inc Derivados de benzazepina utiles para el tratamiento de enfermedades asociadas con el receptor 5ht2c.
PT1838677E (pt) 2004-12-21 2009-11-16 Arena Pharm Inc Formas cristalinas do cloridrato de (r)-8-cloro-1-metil- 2,3,4,5-tetra-hidro-1h-3-benzazepina
CN102631349A (zh) 2004-12-23 2012-08-15 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
EP2518053A1 (en) 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
ES2522587T3 (es) * 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
US8822727B2 (en) * 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
BR112013004707A2 (pt) 2010-09-01 2016-05-10 Arena Pharm Inc administração de um composto antiobesidade a indivíduos com comprometimento renal
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
AU2011296003B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-HT2C agonist useful for weight management
CA2808909A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
EP0080779B1 (en) * 1981-11-27 1986-07-16 Smithkline Beckman Corporation 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism

Also Published As

Publication number Publication date
AU581918B2 (en) 1989-03-09
DK379985D0 (da) 1985-08-21
EP0174118A2 (en) 1986-03-12
KR860002470A (ko) 1986-04-26
AU4648185A (en) 1986-03-13
HU194181B (en) 1988-01-28
NO853255L (no) 1986-03-06
CA1244017A (en) 1988-11-01
ES546285A0 (es) 1986-09-01
GR852041B (en:Method) 1985-12-19
EP0174118A3 (en) 1986-12-30
IL76100A0 (en) 1985-12-31
ZW13385A1 (en) 1985-11-20
DK379985A (da) 1986-03-06
FI853255L (fi) 1986-03-06
PT81018B (en) 1987-06-24
PH20796A (en) 1987-04-14
JPS6168469A (ja) 1986-04-08
ZA856268B (en) 1986-07-30
FI853255A0 (fi) 1985-08-23
NZ213141A (en) 1988-07-28
HUT38617A (en) 1986-06-30
US4541954A (en) 1985-09-17
PT81018A (en) 1985-09-01
FI853255A7 (fi) 1986-03-06
ES8609266A1 (es) 1986-09-01

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