EE200200466A - 8,8a-dihürdroindeno[1,2-d]tiasooli derivaadid, mis on asendatud 8a-asendis, nende valmistamismeetodja kasutamine ravimitena, näiteks anorektiliste toimeainetena - Google Patents

8,8a-dihürdroindeno[1,2-d]tiasooli derivaadid, mis on asendatud 8a-asendis, nende valmistamismeetodja kasutamine ravimitena, näiteks anorektiliste toimeainetena

Info

Publication number
EE200200466A
EE200200466A EEP200200466A EEP200200466A EE200200466A EE 200200466 A EE200200466 A EE 200200466A EE P200200466 A EEP200200466 A EE P200200466A EE P200200466 A EEP200200466 A EE P200200466A EE 200200466 A EE200200466 A EE 200200466A
Authority
EE
Estonia
Prior art keywords
preparation
dihydroindeno
medicaments
derivatives substituted
thiazole derivatives
Prior art date
Application number
EEP200200466A
Other languages
English (en)
Estonian (et)
Inventor
Jaehne Gerhard
Gossel Matthias
Bickel Martin
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of EE200200466A publication Critical patent/EE200200466A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fuses (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EEP200200466A 2000-02-23 2001-02-12 8,8a-dihürdroindeno[1,2-d]tiasooli derivaadid, mis on asendatud 8a-asendis, nende valmistamismeetodja kasutamine ravimitena, näiteks anorektiliste toimeainetena EE200200466A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10008275 2000-02-23
PCT/EP2001/001499 WO2001062746A1 (de) 2000-02-23 2001-02-12 8,8a-DIHYDRO-INDENO[1,2-d]THIAZOL-DERIVATE, DIE IN 8a-STELLUNG SUBSTITUIERT SIND; VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL Z.B. ALS ANOREKTIKA

Publications (1)

Publication Number Publication Date
EE200200466A true EE200200466A (et) 2003-12-15

Family

ID=7631989

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200466A EE200200466A (et) 2000-02-23 2001-02-12 8,8a-dihürdroindeno[1,2-d]tiasooli derivaadid, mis on asendatud 8a-asendis, nende valmistamismeetodja kasutamine ravimitena, näiteks anorektiliste toimeainetena

Country Status (27)

Country Link
US (1) US6403624B1 (xx)
EP (1) EP1259498B1 (xx)
JP (1) JP4898052B2 (xx)
KR (1) KR20020079891A (xx)
CN (1) CN1195747C (xx)
AT (1) ATE283265T1 (xx)
AU (1) AU781003B2 (xx)
BR (1) BR0108605A (xx)
CA (1) CA2400698A1 (xx)
CZ (1) CZ20022838A3 (xx)
DE (1) DE50104600D1 (xx)
EE (1) EE200200466A (xx)
ES (1) ES2231482T3 (xx)
HK (1) HK1055117A1 (xx)
HR (1) HRP20020688A2 (xx)
HU (1) HUP0300140A3 (xx)
IL (1) IL151327A0 (xx)
MX (1) MXPA02007021A (xx)
NO (1) NO20023978L (xx)
NZ (1) NZ520926A (xx)
PL (1) PL357547A1 (xx)
PT (1) PT1259498E (xx)
RU (1) RU2261860C2 (xx)
SK (1) SK12162002A3 (xx)
WO (1) WO2001062746A1 (xx)
YU (1) YU56302A (xx)
ZA (1) ZA200206487B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10142660A1 (de) 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von Derivaten von C2-substituierten Indan-1-ol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE10142659A1 (de) * 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von mehrfach substituierten Indan-1-ol. Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3243385B1 (en) 2011-02-25 2021-01-13 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
AU2013296470B2 (en) 2012-08-02 2016-03-17 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2958562A4 (en) 2013-02-22 2016-08-10 Merck Sharp & Dohme BICYCLIC ANTIDIABETIC COMPOUNDS
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP3551176A4 (en) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. ANTIDIABETIC HETEROCYCLIC COMPOUNDS
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2640358A1 (de) 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
JP2003528825A (ja) 2003-09-30
AU781003B2 (en) 2005-04-28
DE50104600D1 (de) 2004-12-30
US6403624B1 (en) 2002-06-11
HUP0300140A3 (en) 2004-10-28
NZ520926A (en) 2004-08-27
PL357547A1 (en) 2004-07-26
HRP20020688A2 (en) 2004-12-31
NO20023978D0 (no) 2002-08-21
SK12162002A3 (sk) 2003-02-04
WO2001062746A1 (de) 2001-08-30
EP1259498B1 (de) 2004-11-24
ES2231482T3 (es) 2005-05-16
JP4898052B2 (ja) 2012-03-14
CZ20022838A3 (cs) 2002-11-13
CA2400698A1 (en) 2001-08-30
CN1195747C (zh) 2005-04-06
CN1423640A (zh) 2003-06-11
US20020058658A1 (en) 2002-05-16
KR20020079891A (ko) 2002-10-19
IL151327A0 (en) 2003-04-10
MXPA02007021A (es) 2003-03-27
ZA200206487B (en) 2003-10-16
HK1055117A1 (en) 2003-12-24
RU2261860C2 (ru) 2005-10-10
RU2002125460A (ru) 2004-01-10
ATE283265T1 (de) 2004-12-15
BR0108605A (pt) 2002-11-19
AU5615301A (en) 2001-09-03
NO20023978L (no) 2002-10-18
YU56302A (sh) 2005-11-28
HUP0300140A2 (en) 2003-05-28
EP1259498A1 (de) 2002-11-27
PT1259498E (pt) 2005-02-28

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