WO2000046193A3 - Ether derivatives having neuronal activity - Google Patents

Ether derivatives having neuronal activity Download PDF

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Publication number
WO2000046193A3
WO2000046193A3 PCT/US2000/002773 US0002773W WO0046193A3 WO 2000046193 A3 WO2000046193 A3 WO 2000046193A3 US 0002773 W US0002773 W US 0002773W WO 0046193 A3 WO0046193 A3 WO 0046193A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
neuronal activity
ether derivatives
compounds
formula
relates
Prior art date
Application number
PCT/US2000/002773
Other languages
French (fr)
Other versions
WO2000046193A2 (en )
Inventor
Thomas Brumby
Fiona Mcdonald
Eckhard Ottow
Herbert Schneider
Original Assignee
Schering Ag
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Abstract

The invention relates to the compounds of Formula (I), as well as the process for their production and their use as pharmaceutical agents. The invention also relates to the compounds of Formula (IA), their isomers and physiologically compatible salts.
PCT/US2000/002773 1999-02-03 2000-02-03 Ether derivatives having neuronal activity WO2000046193A3 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE19905254.9 1999-02-03
DE1999105254 DE19905254A1 (en) 1999-02-03 1999-02-03 New ether compounds, useful for treating neurological diseases e.g. Parkinson's disease, amyotrophic lateral sclerosis and Alzheimer's disease
US12600899 true 1999-03-24 1999-03-24
US60/126,008 1999-03-24
US49627900 true 2000-02-01 2000-02-01
US09/496,279 2000-02-01

Publications (2)

Publication Number Publication Date
WO2000046193A2 true WO2000046193A2 (en) 2000-08-10
WO2000046193A3 true true WO2000046193A3 (en) 2000-12-21

Family

ID=27218962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002773 WO2000046193A3 (en) 1999-02-03 2000-02-03 Ether derivatives having neuronal activity

Country Status (1)

Country Link
WO (1) WO2000046193A3 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0229630A2 (en) * 1986-01-16 1987-07-22 Hoechst Aktiengesellschaft 1,2-Disubstituted piperidines, process for their preparation and their use as herbicides
WO1996040682A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories 3-pyridyloxyalkyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
WO1996041609A2 (en) * 1995-06-08 1996-12-27 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
WO1997046554A1 (en) * 1996-06-06 1997-12-11 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
WO1999032480A1 (en) * 1997-12-19 1999-07-01 Abbott Laboratories Heterocyclic ether and thioether compounds useful in controlling chemical synaptic transmission
WO1999062881A1 (en) * 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. Aza-heterocyclic compounds used to treat neurological disorders and hair loss
WO1999065451A2 (en) * 1998-06-18 1999-12-23 Smithkline Beecham Corporation Caspases and apoptosis

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0229630A2 (en) * 1986-01-16 1987-07-22 Hoechst Aktiengesellschaft 1,2-Disubstituted piperidines, process for their preparation and their use as herbicides
WO1996040682A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories 3-pyridyloxyalkyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
WO1996041609A2 (en) * 1995-06-08 1996-12-27 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
WO1997046554A1 (en) * 1996-06-06 1997-12-11 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
WO1999032480A1 (en) * 1997-12-19 1999-07-01 Abbott Laboratories Heterocyclic ether and thioether compounds useful in controlling chemical synaptic transmission
WO1999062881A1 (en) * 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. Aza-heterocyclic compounds used to treat neurological disorders and hair loss
WO1999065451A2 (en) * 1998-06-18 1999-12-23 Smithkline Beecham Corporation Caspases and apoptosis

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BYUN, IL SUK ET AL: "Highly diastereoselective reduction of new chiral.alpha.-keto amides", SYNTH. COMMUN. (1995), 25(13), 1963-9, XP000916268 *
CHOJI KASHIMA ET AL.: "Lithium Aluminium Hydride Reduction of Chiral Benzoylformamides Derivwd from Chiral Amino Alcohols", J. CHEM. PERKINS TRANS I, 1987, pages 1495 - 15000, XP000916103 *
FUJISAWA, TAMOTSU ET AL: "Stereocontrolled addition reaction of organometallics to chiral.alpha.-keto amides", BULL. CHEM. SOC. JPN. (1990), 63(7), 1894-7, XP000916071 *
HAMILTON G S: "IMMUNOPHILIN LIGANDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS", EXPERT OPINION ON THERAPEUTIC PATENTS,GB,ASHLEY PUBLICATIONS, vol. 8, no. 9, 1998, pages 1109 - 1124, XP000852684, ISSN: 1354-3776 *
IBUKA, TOSHIRO ET AL: "Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions", J. ORG. CHEM. (1995), 60(7), 2044-58, 1995, XP000916214 *
KOFT, EMIL R. ET AL: "The formation and alkylation of.alpha.-keto amide dianions", TETRAHEDRON LETT. (1986), 27(20), 2227-30, XP000916202 *
NKUNYA, M. H. H. ET AL: "Asymmetric synthesis of.alpha.,.beta.-epoxy sulfonamides (oxiranesulfonamides)", RECL. TRAV. CHIM. PAYS-BAS (1985), 104(10), 253-9, 1985, XP000916218 *
OKAMOTO, YOSHIO ET AL: "Asymmetric polymerization of aromatic isocyanates with optically active anionic initiators", J. POLYM. SCI., PART A: POLYM. CHEM. (1994), 32(2), 309-15, XP000424261 *
THOMAS R M ET AL: "An efficient and selective deprotection of allyl ethers by a CeCl3.7H2O- NaI system", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 40, no. 40, 1 October 1999 (1999-10-01), pages 7293 - 7294, XP004179039, ISSN: 0040-4039 *
TSUGE H ET AL: "Highly Diastereoselective Michael Addition to Optically Active Trifluoromethylated alpha,beta-Unsaturated Sulfonamides Based on Their Hinge-Like Conformation", TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 53, no. 3, 20 January 1997 (1997-01-20), pages 823 - 838, XP004105184, ISSN: 0040-4020 *
VAN DEN BROEK, LEON A. G. M. ET AL: "Asymmetric Diels-Alder reactions with sulfines derived from proline", J. ORG. CHEM. (1984), 49(10), 1691-5, 1984, XP000916217 *

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