EE03832B1 - Heptapeptiidanaloogid - Google Patents
HeptapeptiidanaloogidInfo
- Publication number
- EE03832B1 EE03832B1 EEP199900210A EE9900210A EE03832B1 EE 03832 B1 EE03832 B1 EE 03832B1 EE P199900210 A EEP199900210 A EE P199900210A EE 9900210 A EE9900210 A EE 9900210A EE 03832 B1 EE03832 B1 EE 03832B1
- Authority
- EE
- Estonia
- Prior art keywords
- heptapeptide analogs
- heptapeptide
- analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pregnancy & Childbirth (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9604341A SE9604341D0 (sv) | 1996-11-26 | 1996-11-26 | Hepta-peptide oxytocin analogue |
| PCT/SE1997/001968 WO1998023636A1 (en) | 1996-11-26 | 1997-11-21 | Heptapeptide oxytocin analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9900210A EE9900210A (et) | 1999-12-15 |
| EE03832B1 true EE03832B1 (et) | 2002-08-15 |
Family
ID=20404757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP199900210A EE03832B1 (et) | 1996-11-26 | 1997-11-21 | Heptapeptiidanaloogid |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6143722A (cs) |
| EP (1) | EP0938496B1 (cs) |
| JP (1) | JP3405460B2 (cs) |
| KR (1) | KR100463132B1 (cs) |
| CN (1) | CN1129606C (cs) |
| AR (1) | AR008531A1 (cs) |
| AT (1) | ATE242264T1 (cs) |
| AU (1) | AU713424B2 (cs) |
| BR (1) | BR9713366B1 (cs) |
| CA (1) | CA2272990C (cs) |
| CZ (1) | CZ299532B6 (cs) |
| DE (1) | DE69722651T2 (cs) |
| DK (1) | DK0938496T3 (cs) |
| EE (1) | EE03832B1 (cs) |
| ES (1) | ES2203823T3 (cs) |
| HR (1) | HRP970630B1 (cs) |
| HU (1) | HU228568B1 (cs) |
| IL (1) | IL129519A (cs) |
| LT (1) | LT4650B (cs) |
| LV (1) | LV12350B (cs) |
| MY (1) | MY125555A (cs) |
| NO (1) | NO321380B1 (cs) |
| NZ (1) | NZ336445A (cs) |
| PL (1) | PL189292B1 (cs) |
| PT (1) | PT938496E (cs) |
| RO (1) | RO120772B1 (cs) |
| RU (1) | RU2180668C2 (cs) |
| SE (1) | SE9604341D0 (cs) |
| SI (1) | SI20026B (cs) |
| SK (1) | SK283800B6 (cs) |
| TR (1) | TR199901028T2 (cs) |
| UA (1) | UA54459C2 (cs) |
| WO (1) | WO1998023636A1 (cs) |
| ZA (1) | ZA9710518B (cs) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| US6476072B1 (en) * | 2000-11-21 | 2002-11-05 | Arthur Vanmoor | Method of treating menstrual pain by enhancing the effectiveness of the human immune system |
| WO2003072597A1 (en) * | 2002-02-27 | 2003-09-04 | Ferring Bv | Intermediates and methods for making heptapeptide oxytocin analogues |
| US20060014147A1 (en) * | 2002-05-02 | 2006-01-19 | Stefan Golz | Diagnostics and therapeutics for diseases associated with oxytocin receptor (oxtr) |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| UA76639C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій |
| ES2243840T3 (es) * | 2003-07-25 | 2005-12-01 | Ferring B.V. | Composicion farmaceutica de desmopresina como forma farmaceutica solida de dosificacion y metodo para la fabricacion de la misma. |
| DE60305043T2 (de) * | 2003-11-13 | 2006-11-30 | Ferring B.V. | Blisterverpackung und feste Dosierungsform enthaltend Desmopressin |
| EP1555029A1 (en) | 2004-01-19 | 2005-07-20 | Ferring B.V. | Use of substances having oxytocin antagonistic properties for the preparation of a medicament for treating hypertension |
| US20060171909A1 (en) * | 2005-02-03 | 2006-08-03 | The Procter & Gamble Company | Cosmetic compositions comprising colorants with low free dye |
| SE528446C2 (sv) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse |
| JP5451613B2 (ja) | 2007-08-06 | 2014-03-26 | アラーガン、インコーポレイテッド | デスモプレシン薬物送達のための方法及びデバイス |
| PL2260053T3 (pl) * | 2008-03-31 | 2014-11-28 | Ferring Bv | Analogi oksytocyny |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| ES2756706T3 (es) | 2008-05-21 | 2020-04-27 | Ferring Bv | Desmopresina bucodispersable para aumentar el periodo inicial de sueño ininterrumpido por nocturia |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| TWI463990B (zh) * | 2009-09-21 | 2014-12-11 | Ferring Bv | 催產素受體促進劑 |
| JP2013538186A (ja) | 2010-07-15 | 2013-10-10 | イリイチ・エプシテイン オレグ | 活性化増強型抗体の効果を増大させる方法 |
| JO3400B1 (ar) * | 2010-09-30 | 2019-10-20 | Ferring Bv | مركب صيدلاني من كاربيتوسين |
| EP2684888B1 (en) | 2011-03-09 | 2019-05-15 | Jitsubo Co., Ltd. | Novel cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method |
| CN102875650B (zh) * | 2012-09-26 | 2014-06-11 | 深圳翰宇药业股份有限公司 | 巴卢西班的制备方法 |
| US9365615B2 (en) | 2013-09-09 | 2016-06-14 | Jitsubo Co., Ltd. | Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method |
| EP3037101B1 (en) * | 2014-12-22 | 2019-03-06 | Ferring B.V. | Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies |
| US9375478B1 (en) | 2015-01-30 | 2016-06-28 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| WO2017060339A1 (en) | 2015-10-06 | 2017-04-13 | Ferring B.V. | New methods for making barusiban and its intermediates |
| ES2915948T3 (es) | 2016-01-04 | 2022-06-27 | ObsEva SA | Administración conjunta de alfa-aminoéster de derivado de hidroxipropiltiazolidin-carboxamida y un agente tocolítico |
| MA52548A (fr) | 2016-07-21 | 2021-05-26 | ObsEva SA | Régimes posologiques d'antagonistes de l'ocytocine pour favoriser l'implantation d'embryons et prévenir les fausses couches |
| WO2021043726A1 (en) | 2019-09-03 | 2021-03-11 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| EP4103750A1 (en) | 2020-02-10 | 2022-12-21 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD283404A5 (de) * | 1987-12-21 | 1990-10-10 | Sandoz A. G.,Ch | Verfahren zur herstellung von ciclosporin in nichtsolvatisiertr orthonombischer kristallform |
| US5373089A (en) * | 1988-09-02 | 1994-12-13 | Northwestern University | Oxytocin antagonist |
| CA2036973A1 (en) * | 1990-02-27 | 1991-08-28 | Mark G. Bock | Cyclic hexapeptide oxytocin antagonists |
| SE9002384D0 (sv) * | 1990-07-09 | 1990-07-09 | Ferring Ab | Derivat av baklobshormoner |
| DE4022247A1 (de) * | 1990-07-12 | 1992-01-16 | Hoechst Ag | Verfahren zur extraktiven abtrennung von 2-alkylthio-5-phenylpyrimidinen aus ihren reaktionsgemischen |
| SE501678C2 (sv) * | 1993-07-13 | 1995-04-10 | Ferring Bv | Peptid med oxytocinantagonistaktivitet samt farmaceutisk komposition innehållande nämnda peptid |
| SE523819C2 (sv) | 1994-01-27 | 2004-05-18 | Per-Ingvar Nilsson | Accelerationsmunstycke samt metod för dess användning |
| SE9400918L (sv) | 1994-03-18 | 1995-09-19 | Anne Fjellstad Paulsen | Stabiliserad komposition för oral administrering av peptider |
| SE503085C2 (sv) | 1995-01-25 | 1996-03-25 | Valeo Engine Cooling Ab | Värmeväxlartank med ändstycken, förfarande för framställning av en sådan tank, samt värmeväxlare försedd med en sådan |
-
1996
- 1996-11-26 SE SE9604341A patent/SE9604341D0/xx unknown
-
1997
- 1997-11-21 EE EEP199900210A patent/EE03832B1/xx unknown
- 1997-11-21 NZ NZ336445A patent/NZ336445A/en not_active IP Right Cessation
- 1997-11-21 DK DK97946210T patent/DK0938496T3/da active
- 1997-11-21 PL PL97333876A patent/PL189292B1/pl unknown
- 1997-11-21 EP EP97946210A patent/EP0938496B1/en not_active Expired - Lifetime
- 1997-11-21 CA CA002272990A patent/CA2272990C/en not_active Expired - Lifetime
- 1997-11-21 HU HU0000577A patent/HU228568B1/hu unknown
- 1997-11-21 PT PT97946210T patent/PT938496E/pt unknown
- 1997-11-21 ES ES97946210T patent/ES2203823T3/es not_active Expired - Lifetime
- 1997-11-21 ZA ZA9710518A patent/ZA9710518B/xx unknown
- 1997-11-21 IL IL12951997A patent/IL129519A/en not_active IP Right Cessation
- 1997-11-21 AT AT97946210T patent/ATE242264T1/de active
- 1997-11-21 JP JP52460298A patent/JP3405460B2/ja not_active Expired - Lifetime
- 1997-11-21 CZ CZ0183299A patent/CZ299532B6/cs not_active IP Right Cessation
- 1997-11-21 US US09/308,912 patent/US6143722A/en not_active Expired - Lifetime
- 1997-11-21 TR TR1999/01028T patent/TR199901028T2/xx unknown
- 1997-11-21 SI SI9720076A patent/SI20026B/sl unknown
- 1997-11-21 CN CN97180014A patent/CN1129606C/zh not_active Expired - Fee Related
- 1997-11-21 DE DE69722651T patent/DE69722651T2/de not_active Expired - Lifetime
- 1997-11-21 RO RO99-00593A patent/RO120772B1/ro unknown
- 1997-11-21 WO PCT/SE1997/001968 patent/WO1998023636A1/en not_active Ceased
- 1997-11-21 RU RU99113364/04A patent/RU2180668C2/ru active
- 1997-11-21 HR HR970630A patent/HRP970630B1/xx not_active IP Right Cessation
- 1997-11-21 KR KR10-1999-7004449A patent/KR100463132B1/ko not_active Expired - Lifetime
- 1997-11-21 SK SK704-99A patent/SK283800B6/sk not_active IP Right Cessation
- 1997-11-21 AU AU51429/98A patent/AU713424B2/en not_active Expired
- 1997-11-21 UA UA99042410A patent/UA54459C2/uk unknown
- 1997-11-21 BR BRPI9713366-3A patent/BR9713366B1/pt not_active IP Right Cessation
- 1997-11-25 MY MYPI97005691A patent/MY125555A/en unknown
- 1997-11-26 AR ARP970105543A patent/AR008531A1/es active IP Right Grant
-
1999
- 1999-04-30 LV LVP-99-77A patent/LV12350B/en unknown
- 1999-05-11 LT LT99-052A patent/LT4650B/lt not_active IP Right Cessation
- 1999-05-26 NO NO19992532A patent/NO321380B1/no not_active IP Right Cessation
Also Published As
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| EE03832B1 (et) | Heptapeptiidanaloogid | |
| ID19403A (id) | Senyawa-senyawa heterosiklik | |
| ID19609A (id) | Senyawa-senyawa heterosiklik | |
| ID16152A (id) | Senyawa-senyawa triaril | |
| ID18090A (id) | Mikrokapsul menggunakan iminooksadiazinadiona poliisosianat | |
| ID15904A (id) | Senyawa-senyawa tiofenopirimidina | |
| ID19476A (id) | Senyawa piridilpirol | |
| NO985680D0 (no) | Peptidderivater | |
| DE69716924D1 (de) | Phosphonat-nukleotid-verbindungen | |
| ID18095A (id) | Turunan tetrahidrokinolin | |
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| BR9705635A (pt) | Compostos | |
| NO983849L (no) | Peptidderivater | |
| FI963194A7 (fi) | Syklinen tulehduksenvastainen heptapeptidi | |
| DK0923594T3 (da) | Bromotiacumicinforbindelser | |
| NO974125D0 (no) | N-benzylazoliumderivater | |
| DE69709659D1 (de) | Halopropargyl-einschlussverbindungen | |
| NO983506D0 (no) | Mellomkobling | |
| KR970007831U (ko) | 김밥 말이용 김발 | |
| FI965275A0 (fi) | Aonglaoda i kartong- eller pappersmaskin | |
| KR970056542U (ko) | 넥타이 | |
| FI3003U1 (fi) | Kuormapankka | |
| FI2674U1 (fi) | Långnyppress i en pappers- eller kartongmaskin | |
| FI963563A0 (fi) | Taetningsarrangemang i en fibersbanas torkningsanordning | |
| FI964904A0 (fi) | Tryckknapp i hissen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20091231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20101231 |