EE03687B1 - Furandiarylmethylidene derivatives, method of their preparation and use in therapy - Google Patents

Furandiarylmethylidene derivatives, method of their preparation and use in therapy

Info

Publication number
EE03687B1
EE03687B1 EE9800333A EE9800333A EE03687B1 EE 03687 B1 EE03687 B1 EE 03687B1 EE 9800333 A EE9800333 A EE 9800333A EE 9800333 A EE9800333 A EE 9800333A EE 03687 B1 EE03687 B1 EE 03687B1
Authority
EE
Estonia
Prior art keywords
furandiarylmethylidene
therapy
derivatives
preparation
furandiarylmethylidene derivatives
Prior art date
Application number
EE9800333A
Other languages
Estonian (et)
Other versions
EE9800333A (en
Inventor
Nicolai Eric
Teulon Jean-Marie
Original Assignee
Laboratoires Upsa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Upsa filed Critical Laboratoires Upsa
Publication of EE9800333A publication Critical patent/EE9800333A/en
Publication of EE03687B1 publication Critical patent/EE03687B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
EE9800333A 1996-04-04 1997-04-03 Furandiarylmethylidene derivatives, method of their preparation and use in therapy EE03687B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9604236A FR2747123B1 (en) 1996-04-04 1996-04-04 NOVEL DIARYLMETHYLIDENE TETRAHYDROFURANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THERAPEUTIC USES
FR9607922A FR2747124B1 (en) 1996-04-04 1996-06-26 NOVEL FURANIC DIARYLMETHYLIDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
PCT/FR1997/000602 WO1997037984A1 (en) 1996-04-04 1997-04-03 Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof

Publications (2)

Publication Number Publication Date
EE9800333A EE9800333A (en) 1999-04-15
EE03687B1 true EE03687B1 (en) 2002-04-15

Family

ID=9490907

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800333A EE03687B1 (en) 1996-04-04 1997-04-03 Furandiarylmethylidene derivatives, method of their preparation and use in therapy

Country Status (28)

Country Link
EP (1) EP0891345B1 (en)
JP (1) JP2000508638A (en)
KR (1) KR20000005146A (en)
CN (1) CN1215396A (en)
AR (1) AR006539A1 (en)
AT (1) ATE204268T1 (en)
AU (1) AU717146B2 (en)
BG (1) BG62808B1 (en)
BR (1) BR9708510A (en)
CA (1) CA2248949A1 (en)
CZ (1) CZ318898A3 (en)
DE (1) DE69706157T2 (en)
DK (1) DK0891345T3 (en)
EE (1) EE03687B1 (en)
ES (1) ES2162678T3 (en)
FR (2) FR2747123B1 (en)
GE (1) GEP20032924B (en)
IL (1) IL126105A (en)
NO (1) NO984624L (en)
NZ (1) NZ331672A (en)
PL (1) PL329213A1 (en)
PT (1) PT891345E (en)
RU (1) RU2189979C2 (en)
SI (1) SI0891345T1 (en)
SK (1) SK283292B6 (en)
TW (1) TW353660B (en)
WO (1) WO1997037984A1 (en)
ZA (1) ZA972894B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180651B1 (en) * 1996-04-04 2001-01-30 Bristol-Myers Squibb Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
EP0971910A1 (en) * 1997-04-02 2000-01-19 Merck Frosst Canada & Co. Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors
FR2775477B1 (en) * 1998-02-27 2000-05-19 Union Pharma Scient Appl NOVEL HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
CN1106392C (en) * 2000-10-24 2003-04-23 中国科学院上海有机化学研究所 Butenolide containing no substituent at beta position and its synthesis process
US7323495B2 (en) * 2002-11-05 2008-01-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
ATE515493T1 (en) * 2003-03-31 2011-07-15 Council Scient Ind Res MERCAPTOPHENYLNAPHTHYLMETHANE DERIVATIVES AND THEIR PRODUCTION
CA2519189C (en) 2003-05-07 2012-07-17 Osteologix A/S Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions
US8779168B2 (en) * 2010-12-16 2014-07-15 Transitions Optical, Inc. Lactone compounds and materials made therefrom
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2111288T3 (en) * 1993-01-15 1998-03-01 Searle & Co NEW 3,4-DIARYL THIOPHENES AND ANALOGS OF THE SAME USEFUL AS ANTI-INFLAMMATORY AGENTS.
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge

Also Published As

Publication number Publication date
BR9708510A (en) 1999-08-03
SK283292B6 (en) 2003-05-02
ES2162678T3 (en) 2002-01-01
AU717146B2 (en) 2000-03-16
CA2248949A1 (en) 1997-10-16
FR2747123B1 (en) 1998-06-26
FR2747124A1 (en) 1997-10-10
IL126105A0 (en) 1999-05-09
RU2189979C2 (en) 2002-09-27
WO1997037984A1 (en) 1997-10-16
TW353660B (en) 1999-03-01
BG102771A (en) 1999-06-30
AR006539A1 (en) 1999-09-08
AU2393397A (en) 1997-10-29
BG62808B1 (en) 2000-08-31
SI0891345T1 (en) 2002-02-28
CZ318898A3 (en) 1999-01-13
PT891345E (en) 2002-02-28
EP0891345B1 (en) 2001-08-16
DE69706157T2 (en) 2002-04-11
ATE204268T1 (en) 2001-09-15
GEP20032924B (en) 2003-03-25
NZ331672A (en) 2000-02-28
DE69706157D1 (en) 2001-09-20
ZA972894B (en) 1997-11-04
CN1215396A (en) 1999-04-28
PL329213A1 (en) 1999-03-15
KR20000005146A (en) 2000-01-25
EE9800333A (en) 1999-04-15
FR2747123A1 (en) 1997-10-10
IL126105A (en) 2001-08-26
DK0891345T3 (en) 2001-12-03
NO984624L (en) 1998-11-30
EP0891345A1 (en) 1999-01-20
SK137598A3 (en) 1999-02-11
NO984624D0 (en) 1998-10-02
FR2747124B1 (en) 1998-06-26
JP2000508638A (en) 2000-07-11

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20021231

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Effective date: 20101231