NO984624L - New furan-diarylmethylidene derivatives, methods of their preparation and therapeutic uses thereof - Google Patents

New furan-diarylmethylidene derivatives, methods of their preparation and therapeutic uses thereof

Info

Publication number
NO984624L
NO984624L NO984624A NO984624A NO984624L NO 984624 L NO984624 L NO 984624L NO 984624 A NO984624 A NO 984624A NO 984624 A NO984624 A NO 984624A NO 984624 L NO984624 L NO 984624L
Authority
NO
Norway
Prior art keywords
preparation
methods
therapeutic uses
diarylmethylidene
derivatives
Prior art date
Application number
NO984624A
Other languages
Norwegian (no)
Other versions
NO984624D0 (en
Inventor
Eric Nicolai
Jean-Marie Teulon
Original Assignee
Union Pharma Scient Appl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Pharma Scient Appl filed Critical Union Pharma Scient Appl
Publication of NO984624D0 publication Critical patent/NO984624D0/en
Publication of NO984624L publication Critical patent/NO984624L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO984624A 1996-04-04 1998-10-02 New furan-diarylmethylidene derivatives, methods of their preparation and therapeutic uses thereof NO984624L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9604236A FR2747123B1 (en) 1996-04-04 1996-04-04 NOVEL DIARYLMETHYLIDENE TETRAHYDROFURANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THERAPEUTIC USES
FR9607922A FR2747124B1 (en) 1996-04-04 1996-06-26 NOVEL FURANIC DIARYLMETHYLIDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
PCT/FR1997/000602 WO1997037984A1 (en) 1996-04-04 1997-04-03 Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof

Publications (2)

Publication Number Publication Date
NO984624D0 NO984624D0 (en) 1998-10-02
NO984624L true NO984624L (en) 1998-11-30

Family

ID=9490907

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984624A NO984624L (en) 1996-04-04 1998-10-02 New furan-diarylmethylidene derivatives, methods of their preparation and therapeutic uses thereof

Country Status (28)

Country Link
EP (1) EP0891345B1 (en)
JP (1) JP2000508638A (en)
KR (1) KR20000005146A (en)
CN (1) CN1215396A (en)
AR (1) AR006539A1 (en)
AT (1) ATE204268T1 (en)
AU (1) AU717146B2 (en)
BG (1) BG62808B1 (en)
BR (1) BR9708510A (en)
CA (1) CA2248949A1 (en)
CZ (1) CZ318898A3 (en)
DE (1) DE69706157T2 (en)
DK (1) DK0891345T3 (en)
EE (1) EE03687B1 (en)
ES (1) ES2162678T3 (en)
FR (2) FR2747123B1 (en)
GE (1) GEP20032924B (en)
IL (1) IL126105A (en)
NO (1) NO984624L (en)
NZ (1) NZ331672A (en)
PL (1) PL329213A1 (en)
PT (1) PT891345E (en)
RU (1) RU2189979C2 (en)
SI (1) SI0891345T1 (en)
SK (1) SK283292B6 (en)
TW (1) TW353660B (en)
WO (1) WO1997037984A1 (en)
ZA (1) ZA972894B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180651B1 (en) * 1996-04-04 2001-01-30 Bristol-Myers Squibb Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
JP2001518087A (en) * 1997-04-02 2001-10-09 メルク フロスト カナダ アンド カンパニー Α-Methylene-γ-lactones as selective cyclooxygenase-2 inhibitors
FR2775477B1 (en) * 1998-02-27 2000-05-19 Union Pharma Scient Appl NOVEL HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
CN1106392C (en) * 2000-10-24 2003-04-23 中国科学院上海有机化学研究所 Butenolide containing no substituent at beta position and its synthesis process
MXPA05004794A (en) * 2002-11-05 2005-08-19 Magnachem Int Lab Inc Synthetic lactone formulations and method of use.
ATE515493T1 (en) * 2003-03-31 2011-07-15 Council Scient Ind Res MERCAPTOPHENYLNAPHTHYLMETHANE DERIVATIVES AND THEIR PRODUCTION
DE602004002832T2 (en) 2003-05-07 2007-06-06 Osteologix A/S TREATMENT OF CARTILAGE / BONE DISEASES WITH WATER-SOLUBLE STRONTIUM SALTS
US8779168B2 (en) * 2010-12-16 2014-07-15 Transitions Optical, Inc. Lactone compounds and materials made therefrom
US20240165148A1 (en) 2021-03-15 2024-05-23 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2243199C (en) * 1993-01-15 2005-08-02 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge

Also Published As

Publication number Publication date
ATE204268T1 (en) 2001-09-15
GEP20032924B (en) 2003-03-25
CZ318898A3 (en) 1999-01-13
JP2000508638A (en) 2000-07-11
NZ331672A (en) 2000-02-28
SI0891345T1 (en) 2002-02-28
EP0891345B1 (en) 2001-08-16
AU2393397A (en) 1997-10-29
ES2162678T3 (en) 2002-01-01
PT891345E (en) 2002-02-28
NO984624D0 (en) 1998-10-02
BG62808B1 (en) 2000-08-31
KR20000005146A (en) 2000-01-25
DK0891345T3 (en) 2001-12-03
DE69706157T2 (en) 2002-04-11
BG102771A (en) 1999-06-30
EP0891345A1 (en) 1999-01-20
WO1997037984A1 (en) 1997-10-16
FR2747124A1 (en) 1997-10-10
ZA972894B (en) 1997-11-04
IL126105A0 (en) 1999-05-09
EE9800333A (en) 1999-04-15
TW353660B (en) 1999-03-01
AR006539A1 (en) 1999-09-08
SK137598A3 (en) 1999-02-11
FR2747123B1 (en) 1998-06-26
RU2189979C2 (en) 2002-09-27
SK283292B6 (en) 2003-05-02
CN1215396A (en) 1999-04-28
FR2747123A1 (en) 1997-10-10
DE69706157D1 (en) 2001-09-20
FR2747124B1 (en) 1998-06-26
EE03687B1 (en) 2002-04-15
BR9708510A (en) 1999-08-03
PL329213A1 (en) 1999-03-15
CA2248949A1 (en) 1997-10-16
IL126105A (en) 2001-08-26
AU717146B2 (en) 2000-03-16

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