EE03237B1 - Kontrastaine, selle valmistamismeetod ja kasutamine, kopolümeerne pindaktiivne aine, seda sisaldav emulsioon ja nende kasutamine - Google Patents
Kontrastaine, selle valmistamismeetod ja kasutamine, kopolümeerne pindaktiivne aine, seda sisaldav emulsioon ja nende kasutamineInfo
- Publication number
- EE03237B1 EE03237B1 EE9600025A EE9600025A EE03237B1 EE 03237 B1 EE03237 B1 EE 03237B1 EE 9600025 A EE9600025 A EE 9600025A EE 9600025 A EE9600025 A EE 9600025A EE 03237 B1 EE03237 B1 EE 03237B1
- Authority
- EE
- Estonia
- Prior art keywords
- pct
- date mar
- preparation
- contrast agent
- sec
- Prior art date
Links
- 239000004094 surface-active agent Substances 0.000 title abstract 3
- 239000002872 contrast media Substances 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 title 1
- 239000000839 emulsion Substances 0.000 title 1
- 229920001400 block copolymer Polymers 0.000 abstract 2
- 239000007789 gas Substances 0.000 abstract 2
- 229920000578 graft copolymer Polymers 0.000 abstract 2
- 125000000962 organic group Chemical group 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/34—Higher-molecular-weight carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Vending Machines For Individual Products (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939318288A GB9318288D0 (en) | 1993-09-03 | 1993-09-03 | Improvements in or relating to contrast agents |
PCT/GB1994/001923 WO1995006518A1 (en) | 1993-09-03 | 1994-09-05 | Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging |
Publications (1)
Publication Number | Publication Date |
---|---|
EE03237B1 true EE03237B1 (et) | 1999-12-15 |
Family
ID=10741456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9600025A EE03237B1 (et) | 1993-09-03 | 1994-09-05 | Kontrastaine, selle valmistamismeetod ja kasutamine, kopolümeerne pindaktiivne aine, seda sisaldav emulsioon ja nende kasutamine |
Country Status (22)
Country | Link |
---|---|
US (1) | US5919434A (et) |
EP (1) | EP0717658B1 (et) |
JP (1) | JP3552721B2 (et) |
CN (1) | CN1072521C (et) |
AT (1) | ATE216282T1 (et) |
AU (1) | AU689495B2 (et) |
BG (1) | BG100467A (et) |
CA (1) | CA2170906A1 (et) |
CZ (1) | CZ62796A3 (et) |
DE (1) | DE69430432T2 (et) |
EE (1) | EE03237B1 (et) |
ES (1) | ES2177582T3 (et) |
FI (1) | FI960983A (et) |
GB (1) | GB9318288D0 (et) |
HU (1) | HUT75289A (et) |
LV (1) | LV11438B (et) |
NO (1) | NO960824L (et) |
NZ (1) | NZ271704A (et) |
PL (1) | PL313290A1 (et) |
SG (1) | SG46373A1 (et) |
SK (1) | SK26096A3 (et) |
WO (1) | WO1995006518A1 (et) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9417941D0 (en) * | 1994-09-06 | 1994-10-26 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US5820850A (en) * | 1995-06-07 | 1998-10-13 | Molecular Biosystems, Inc. | Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents |
US5674469A (en) * | 1995-06-07 | 1997-10-07 | Molecular Biosystems, Inc. | Gas-exchange method of making gas-filled microspheres |
GB9511488D0 (en) * | 1995-06-07 | 1995-08-02 | Nycomed Imaging As | Improvements in or relating to contrast agents |
DE19626530A1 (de) * | 1996-07-02 | 1998-01-15 | Byk Gulden Lomberg Chem Fab | MR-Kontrastmittelzubereitungen |
GB9624548D0 (en) * | 1996-11-25 | 1997-01-15 | Nycomed Imaging As | Improvements in or relating to surfactants |
US6193951B1 (en) * | 1997-04-30 | 2001-02-27 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents |
US20020159951A1 (en) * | 1997-05-06 | 2002-10-31 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
DE19742761A1 (de) * | 1997-09-27 | 1999-04-01 | Gerd Dr Rossmy | An ihrer Oberfläche anisotrop verteilte überwiegend hydrophile und überwiegend hydrophobe Domänen aufweisende amphiphile Teilchen oder Moleküle |
US6309420B1 (en) * | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US7919119B2 (en) * | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
US6395300B1 (en) | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
WO2001012071A1 (en) * | 1999-08-13 | 2001-02-22 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents and for lymphatic system |
AU6636000A (en) * | 1999-08-13 | 2001-03-13 | Point Biomedical Corporation | Hollow microspheres with controlled fragility for medical use |
US20020153508A1 (en) * | 2000-06-29 | 2002-10-24 | Lynch Matthew Lawrence | Cubic liquid crystalline compositions and methods for their preparation |
US20070191964A1 (en) * | 2001-04-04 | 2007-08-16 | Arthrocare Corporation | Enhanced visibility materials for implantation in hard tissue |
WO2002080774A2 (en) * | 2001-04-06 | 2002-10-17 | Bracco Research S.A. | Method for improved measurement of local physical parameters in afluid-filled cavity |
EP1485196A1 (en) * | 2002-03-20 | 2004-12-15 | Rhodia Inc. | Vesicles comprising an amphiphilic di-block copolymer and a hydrophobic compound. |
US6919068B2 (en) * | 2002-05-17 | 2005-07-19 | Point Biomedical Corporation | Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging |
US20030215394A1 (en) * | 2002-05-17 | 2003-11-20 | Short Robert E. | Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream |
US20040185108A1 (en) * | 2003-03-18 | 2004-09-23 | Short Robert E. | Method of preparing gas-filled polymer matrix microparticles useful for delivering drug |
DE602004028930D1 (de) | 2003-04-29 | 2010-10-14 | Avi Biopharma Inc | Zusammensetzungen zur verbesserung der antisense-wirksamkeit und des transports von nukleinsäureanalog in zellen |
US8052669B2 (en) | 2004-02-25 | 2011-11-08 | Femasys Inc. | Methods and devices for delivery of compositions to conduits |
US8048086B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
US9238127B2 (en) | 2004-02-25 | 2016-01-19 | Femasys Inc. | Methods and devices for delivering to conduit |
US8048101B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
WO2005115603A2 (en) * | 2004-05-17 | 2005-12-08 | Exxonmobil Upstream Research Company Corp-Urc-Sw348 | Oil spill dispersants and dispersion methods |
AU2005295261A1 (en) * | 2004-10-19 | 2006-04-27 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health | Methods and compositions for protecting cells from ultrasound-mediated cytolysis |
US7608567B2 (en) * | 2005-05-12 | 2009-10-27 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
US7677315B2 (en) | 2005-05-12 | 2010-03-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
US7662753B2 (en) | 2005-05-12 | 2010-02-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
US8123693B2 (en) | 2005-06-20 | 2012-02-28 | Conceptus, Inc. | Methods and devices for determining lumen occlusion |
JP5214114B2 (ja) * | 2006-05-25 | 2013-06-19 | 花王株式会社 | 微細気泡含有液体組成物の製造法 |
DE102006047617B4 (de) | 2006-10-09 | 2008-11-27 | Clariant International Limited | Verfahren zur Herstellung basischer (Meth)acrylamide |
WO2008094236A1 (en) * | 2007-01-30 | 2008-08-07 | Exxonmobil Upstream Research Company | Floating dispersant paste |
DE102008013620A1 (de) * | 2008-02-12 | 2009-08-13 | Charité - Universitätsmedizin Berlin | Knochenzementmischung zur Herstellung eines MRT-signalgebenden Knochenzements |
DE102008017216B4 (de) | 2008-04-04 | 2013-08-14 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden |
US10070888B2 (en) | 2008-10-03 | 2018-09-11 | Femasys, Inc. | Methods and devices for sonographic imaging |
US9554826B2 (en) | 2008-10-03 | 2017-01-31 | Femasys, Inc. | Contrast agent injection system for sonographic imaging |
PL2346573T3 (pl) * | 2008-11-20 | 2014-12-31 | Laboratori Derivati Organici S P A | Wykorzystanie siarczanu heparanu w kosmetycznych i dermatologicznych preparatach |
US8734409B2 (en) | 2008-12-31 | 2014-05-27 | Kci Licensing, Inc. | Systems for providing fluid flow to tissues |
DE102009031059A1 (de) | 2009-06-30 | 2011-01-05 | Clariant International Ltd. | Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen |
DE102009042522A1 (de) | 2009-09-22 | 2011-04-07 | Clariant International Ltd. | Kontinuierliches Umesterungsverfahren |
DE102009042523B4 (de) | 2009-09-22 | 2012-02-16 | Clariant International Ltd. | Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen |
US8585616B2 (en) * | 2009-10-09 | 2013-11-19 | Conceptus, Inc. | Methods and apparatus for determining fallopian tube occlusion |
DE102010056565A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Ltd. | Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere |
DE102010056564A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Limited | Hydroxylgruppen und Estergruppen tragende Polymere und Verfahren zu ihrer Herstellung |
DE102011005444A1 (de) * | 2011-03-11 | 2012-09-13 | Innora Gmbh | Festes, negatives Röntgenkontrastmittel zur Darstellung des Gastrointestinaltraktes |
US9982812B2 (en) * | 2014-03-10 | 2018-05-29 | Saint-Gobain Performance Plastics Corporation | Multilayer flexible tube and methods for making same |
US10295089B2 (en) * | 2014-03-10 | 2019-05-21 | Saint-Gobain Performance Plastics Corporation | Multilayer flexible tube and methods for making same |
TWI556837B (zh) * | 2014-07-18 | 2016-11-11 | 國立清華大學 | 用於藥物傳遞之奈/微米氣泡 |
BR112017013787A2 (pt) | 2014-12-31 | 2018-03-13 | Lantheus Medical Imaging, Inc. | Composições de microesfera de gás lipídio- encapsulado e métodos relacionados |
CA3022698A1 (en) | 2016-05-04 | 2017-11-09 | Lantheus Medical Imaging, Inc. | Methods and devices for preparation of ultrasound contrast agents |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
US10717812B2 (en) * | 2017-03-16 | 2020-07-21 | Board Of Regents, The University Of Texas System | Lactone-epoxide statistical copolymers |
WO2020060275A1 (ko) | 2018-09-21 | 2020-03-26 | 삼육대학교산학협력단 | 나노버블과 약물이 함유된 약물담지체를 활용한 초음파 유도 약물전달 시스템 |
CN112341870A (zh) * | 2019-08-08 | 2021-02-09 | 李石良 | 一种增强超声介导成像的涂层材料 |
EP4076717B1 (de) * | 2019-12-17 | 2024-02-21 | Wacker Chemie AG | Kleinteilige wässrige partikelstabilisierte pickering emulsion und daraus hergestellte partikel |
WO2024104274A1 (zh) * | 2022-11-14 | 2024-05-23 | 浙江省化工研究院有限公司 | 表面活性剂、其制备方法及应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
US5425366A (en) * | 1988-02-05 | 1995-06-20 | Schering Aktiengesellschaft | Ultrasonic contrast agents for color Doppler imaging |
US5730954A (en) * | 1988-08-23 | 1998-03-24 | Schering Aktiengesellschaft | Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent |
US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
IN172208B (et) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
PH31064A (en) * | 1990-09-07 | 1998-02-05 | Nycomed As Of Nycoveten | Polymers containing diester units. |
DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
CA2078388A1 (en) * | 1991-10-02 | 1993-04-03 | Mridula Nair | Biocompatible emulsion particles |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
RU2122432C1 (ru) * | 1992-03-06 | 1998-11-27 | Нюкомед Имагинг АС | Контрастные агенты и их применение |
GB9204918D0 (en) * | 1992-03-06 | 1992-04-22 | Nycomed As | Chemical compounds |
DE4219723A1 (de) * | 1992-06-13 | 1993-12-16 | Schering Ag | Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik |
US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
CA2164813C (en) * | 1993-07-30 | 2009-11-24 | Ernest G. Schutt | Stabilized microbubble compositions for ultrasound |
-
1993
- 1993-09-03 GB GB939318288A patent/GB9318288D0/en active Pending
-
1994
- 1994-09-05 ES ES94925549T patent/ES2177582T3/es not_active Expired - Lifetime
- 1994-09-05 AU AU75415/94A patent/AU689495B2/en not_active Ceased
- 1994-09-05 WO PCT/GB1994/001923 patent/WO1995006518A1/en not_active Application Discontinuation
- 1994-09-05 HU HU9600515A patent/HUT75289A/hu unknown
- 1994-09-05 CZ CZ96627A patent/CZ62796A3/cs unknown
- 1994-09-05 AT AT94925549T patent/ATE216282T1/de not_active IP Right Cessation
- 1994-09-05 CA CA002170906A patent/CA2170906A1/en not_active Abandoned
- 1994-09-05 NZ NZ271704A patent/NZ271704A/en unknown
- 1994-09-05 US US08/602,797 patent/US5919434A/en not_active Expired - Fee Related
- 1994-09-05 PL PL94313290A patent/PL313290A1/xx unknown
- 1994-09-05 SK SK260-96A patent/SK26096A3/sk unknown
- 1994-09-05 DE DE69430432T patent/DE69430432T2/de not_active Expired - Fee Related
- 1994-09-05 JP JP50801995A patent/JP3552721B2/ja not_active Expired - Fee Related
- 1994-09-05 CN CN94193813A patent/CN1072521C/zh not_active Expired - Fee Related
- 1994-09-05 SG SG1996003791A patent/SG46373A1/en unknown
- 1994-09-05 EE EE9600025A patent/EE03237B1/et unknown
- 1994-09-05 EP EP94925549A patent/EP0717658B1/en not_active Expired - Lifetime
-
1996
- 1996-02-29 NO NO960824A patent/NO960824L/no not_active Application Discontinuation
- 1996-03-01 FI FI960983A patent/FI960983A/fi unknown
- 1996-03-29 BG BG100467A patent/BG100467A/xx unknown
- 1996-04-02 LV LVP-96-94A patent/LV11438B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CZ62796A3 (en) | 1997-03-12 |
EP0717658B1 (en) | 2002-04-17 |
CN1072521C (zh) | 2001-10-10 |
NO960824L (no) | 1996-04-29 |
BG100467A (en) | 1996-12-31 |
JPH09503202A (ja) | 1997-03-31 |
DE69430432D1 (de) | 2002-05-23 |
ES2177582T3 (es) | 2002-12-16 |
SG46373A1 (en) | 1998-01-20 |
PL313290A1 (en) | 1996-06-24 |
EP0717658A1 (en) | 1996-06-26 |
CA2170906A1 (en) | 1995-03-09 |
GB9318288D0 (en) | 1993-10-20 |
NO960824D0 (no) | 1996-02-29 |
ATE216282T1 (de) | 2002-05-15 |
FI960983A0 (fi) | 1996-03-01 |
SK26096A3 (en) | 1996-08-07 |
AU689495B2 (en) | 1998-04-02 |
HUT75289A (en) | 1997-05-28 |
US5919434A (en) | 1999-07-06 |
DE69430432T2 (de) | 2002-12-12 |
WO1995006518A1 (en) | 1995-03-09 |
FI960983A (fi) | 1996-03-01 |
AU7541594A (en) | 1995-03-22 |
HU9600515D0 (en) | 1996-04-29 |
JP3552721B2 (ja) | 2004-08-11 |
LV11438A (lv) | 1996-08-20 |
NZ271704A (en) | 1997-12-19 |
LV11438B (en) | 1996-12-20 |
CN1136285A (zh) | 1996-11-20 |
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