ECSP22091613A - Antagonistas del receptor de adenosina a2a - Google Patents
Antagonistas del receptor de adenosina a2aInfo
- Publication number
- ECSP22091613A ECSP22091613A ECSENADI202291613A ECDI202291613A ECSP22091613A EC SP22091613 A ECSP22091613 A EC SP22091613A EC SENADI202291613 A ECSENADI202291613 A EC SENADI202291613A EC DI202291613 A ECDI202291613 A EC DI202291613A EC SP22091613 A ECSP22091613 A EC SP22091613A
- Authority
- EC
- Ecuador
- Prior art keywords
- adenosine
- receptor antagonists
- compounds
- application
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2006823.5A GB202006823D0 (en) | 2020-05-07 | 2020-05-07 | Antagonist compounds |
| GBGB2019922.0A GB202019922D0 (en) | 2020-12-16 | 2020-12-16 | Antagonist compounds |
| PCT/GB2021/051106 WO2021224636A1 (en) | 2020-05-07 | 2021-05-06 | Antagonists of the adenosine a2a receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP22091613A true ECSP22091613A (es) | 2023-03-31 |
Family
ID=75977772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202291613A ECSP22091613A (es) | 2020-05-07 | 2022-12-01 | Antagonistas del receptor de adenosina a2a |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US12617796B2 (enExample) |
| EP (2) | EP4146654A1 (enExample) |
| JP (2) | JP7724239B2 (enExample) |
| KR (2) | KR20260083407A (enExample) |
| CN (2) | CN122010947A (enExample) |
| AU (1) | AU2021266433A1 (enExample) |
| BR (1) | BR112022022437A2 (enExample) |
| CA (1) | CA3181354A1 (enExample) |
| CL (1) | CL2022003055A1 (enExample) |
| CO (1) | CO2022017618A2 (enExample) |
| EC (1) | ECSP22091613A (enExample) |
| GB (1) | GB2609879B (enExample) |
| IL (2) | IL297963A (enExample) |
| MX (1) | MX2022013946A (enExample) |
| PE (1) | PE20230769A1 (enExample) |
| PH (1) | PH12022552987A1 (enExample) |
| WO (1) | WO2021224636A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023114157A2 (en) * | 2021-12-17 | 2023-06-22 | Merck Sharp & Dohme Llc | Pyrazolopyrimidine derivatives and methods of use thereof for the treatment of herpesviruses |
| CN116283994B (zh) * | 2021-12-20 | 2025-01-07 | 艾立康药业股份有限公司 | 作为mat2a抑制剂的杂环化合物 |
| TWI861659B (zh) * | 2022-01-18 | 2024-11-11 | 大陸商江蘇亞堯生物科技有限公司 | 吡唑並嘧啶化合物及其組合物、製備方法和用途 |
| AU2023252914A1 (en) | 2022-04-13 | 2024-10-17 | Arcus Biosciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| AU2024338138A1 (en) * | 2023-09-08 | 2026-03-19 | Satellos Bioscience Inc. | Ap2 associated kinase 1 inhibitors and uses thereof |
| IL328105A (en) | 2023-10-30 | 2026-06-01 | Johnson & Johnson Entpr Innovation Inc | Safe administration of a2a rector antagonist |
| WO2025123251A1 (en) | 2023-12-13 | 2025-06-19 | Johnson & Johnson Enterprise Innovation Inc. | Crystalline forms of a2a receptor antagonist, preparation methods, and uses thereof |
| WO2025123253A1 (en) | 2023-12-13 | 2025-06-19 | Johnson & Johnson Enterprise Innovation Inc. | Pharmaceutical compositions of an a2a receptor antagonist |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| UY41082A (es) | 2024-03-28 | 2025-08-29 | Pi Industries Ltd | Compuestos bicíclicos condensados y su uso como agentes de control de plagas |
| CN120093763A (zh) * | 2025-03-25 | 2025-06-06 | 上海天龙生物科技有限公司 | 治疗前列腺疾病和腺体类散结节的药物组合物及其应用 |
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| JP2000302680A (ja) | 1999-04-23 | 2000-10-31 | Takeda Chem Ind Ltd | 脳保護剤 |
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| AU2021228284A1 (en) | 2020-02-28 | 2022-09-29 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
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| GB202019622D0 (en) | 2020-12-11 | 2021-01-27 | Adorx Therapeutics Ltd | Antagonist compounds |
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2021
- 2021-05-06 IL IL297963A patent/IL297963A/en unknown
- 2021-05-06 WO PCT/GB2021/051106 patent/WO2021224636A1/en not_active Ceased
- 2021-05-06 CN CN202511968176.0A patent/CN122010947A/zh active Pending
- 2021-05-06 PE PE2022002570A patent/PE20230769A1/es unknown
- 2021-05-06 KR KR1020267013983A patent/KR20260083407A/ko active Pending
- 2021-05-06 PH PH1/2022/552987A patent/PH12022552987A1/en unknown
- 2021-05-06 JP JP2022567895A patent/JP7724239B2/ja active Active
- 2021-05-06 BR BR112022022437A patent/BR112022022437A2/pt unknown
- 2021-05-06 MX MX2022013946A patent/MX2022013946A/es unknown
- 2021-05-06 KR KR1020227042714A patent/KR20230035236A/ko active Pending
- 2021-05-06 GB GB2217519.4A patent/GB2609879B/en active Active
- 2021-05-06 EP EP21726445.6A patent/EP4146654A1/en active Pending
- 2021-05-06 CN CN202180047824.2A patent/CN115996929B/zh active Active
- 2021-05-06 CA CA3181354A patent/CA3181354A1/en active Pending
- 2021-05-06 US US17/923,374 patent/US12617796B2/en active Active
- 2021-05-06 AU AU2021266433A patent/AU2021266433A1/en active Pending
- 2021-05-06 EP EP26172595.6A patent/EP4789672A2/en active Pending
-
2022
- 2022-11-04 CL CL2022003055A patent/CL2022003055A1/es unknown
- 2022-12-01 EC ECSENADI202291613A patent/ECSP22091613A/es unknown
- 2022-12-06 CO CONC2022/0017618A patent/CO2022017618A2/es unknown
-
2025
- 2025-08-04 JP JP2025130117A patent/JP2025183201A/ja active Pending
- 2025-10-19 IL IL324071A patent/IL324071A/en unknown
Also Published As
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|---|---|
| JP2023525762A (ja) | 2023-06-19 |
| IL297963A (en) | 2023-01-01 |
| JP7724239B2 (ja) | 2025-08-15 |
| AU2021266433A1 (en) | 2022-12-15 |
| EP4789672A2 (en) | 2026-08-12 |
| PE20230769A1 (es) | 2023-05-09 |
| GB202217519D0 (en) | 2023-01-04 |
| CN122010947A (zh) | 2026-05-12 |
| CO2022017618A2 (es) | 2023-02-16 |
| WO2021224636A1 (en) | 2021-11-11 |
| BR112022022437A2 (pt) | 2023-01-03 |
| KR20260083407A (ko) | 2026-06-05 |
| IL324071A (en) | 2025-12-01 |
| GB2609879A (en) | 2023-02-15 |
| US20230203041A1 (en) | 2023-06-29 |
| CL2022003055A1 (es) | 2023-07-07 |
| CA3181354A1 (en) | 2021-11-11 |
| CN115996929A (zh) | 2023-04-21 |
| EP4146654A1 (en) | 2023-03-15 |
| PH12022552987A1 (en) | 2024-02-26 |
| KR20230035236A (ko) | 2023-03-13 |
| MX2022013946A (es) | 2023-02-01 |
| CN115996929B (zh) | 2026-01-13 |
| US12617796B2 (en) | 2026-05-05 |
| JP2025183201A (ja) | 2025-12-16 |
| GB2609879B (en) | 2023-08-16 |
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