ECSP22091613A - Antagonistas del receptor de adenosina a2a - Google Patents
Antagonistas del receptor de adenosina a2aInfo
- Publication number
- ECSP22091613A ECSP22091613A ECSENADI202291613A ECDI202291613A ECSP22091613A EC SP22091613 A ECSP22091613 A EC SP22091613A EC SENADI202291613 A ECSENADI202291613 A EC SENADI202291613A EC DI202291613 A ECDI202291613 A EC DI202291613A EC SP22091613 A ECSP22091613 A EC SP22091613A
- Authority
- EC
- Ecuador
- Prior art keywords
- adenosine
- receptor antagonists
- compounds
- application
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula I mostrados a continuación: (I) en donde R0, R1, R2, R3 y A son cada uno como se define en la solicitud. La presente invención también se refiere a los procesos para la preparación de estos compuestos, a las composiciones farmacéuticas que los comprenden, y a su aplicación en el tratamiento de enfermedades o afecciones en las que está implicada la actividad del receptor de adenosina A2a, tales como, por ejemplo, el cáncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2006823.5A GB202006823D0 (en) | 2020-05-07 | 2020-05-07 | Antagonist compounds |
GBGB2019922.0A GB202019922D0 (en) | 2020-12-16 | 2020-12-16 | Antagonist compounds |
PCT/GB2021/051106 WO2021224636A1 (en) | 2020-05-07 | 2021-05-06 | Antagonists of the adenosine a2a receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP22091613A true ECSP22091613A (es) | 2023-03-31 |
Family
ID=75977772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202291613A ECSP22091613A (es) | 2020-05-07 | 2022-12-01 | Antagonistas del receptor de adenosina a2a |
Country Status (16)
Country | Link |
---|---|
US (1) | US20230203041A1 (es) |
EP (1) | EP4146654A1 (es) |
JP (1) | JP2023525762A (es) |
KR (1) | KR20230035236A (es) |
CN (1) | CN115996929A (es) |
AU (1) | AU2021266433A1 (es) |
BR (1) | BR112022022437A2 (es) |
CA (1) | CA3181354A1 (es) |
CL (1) | CL2022003055A1 (es) |
CO (1) | CO2022017618A2 (es) |
EC (1) | ECSP22091613A (es) |
GB (1) | GB2609879B (es) |
IL (1) | IL297963A (es) |
MX (1) | MX2022013946A (es) |
PE (1) | PE20230769A1 (es) |
WO (1) | WO2021224636A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023138343A1 (zh) * | 2022-01-18 | 2023-07-27 | 江苏亚尧生物科技有限公司 | 新型吡唑并嘧啶化合物及其组合物、制备方法和用途 |
WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2483306A1 (en) * | 2002-04-23 | 2003-11-06 | Shionogi & Co., Ltd. | Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same |
EP2402337A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
EP2402345A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazole fused bicyclic compounds |
EP2402344A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazole fused bicyclic compounds |
US10894830B2 (en) | 2015-11-03 | 2021-01-19 | Janssen Biotech, Inc. | Antibodies specifically binding PD-1, TIM-3 or PD-1 and TIM-3 and their uses |
US20190225689A1 (en) | 2018-01-22 | 2019-07-25 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-pd-1 antibodies |
-
2021
- 2021-05-06 CN CN202180047824.2A patent/CN115996929A/zh active Pending
- 2021-05-06 US US17/923,374 patent/US20230203041A1/en active Pending
- 2021-05-06 JP JP2022567895A patent/JP2023525762A/ja active Pending
- 2021-05-06 GB GB2217519.4A patent/GB2609879B/en active Active
- 2021-05-06 CA CA3181354A patent/CA3181354A1/en active Pending
- 2021-05-06 MX MX2022013946A patent/MX2022013946A/es unknown
- 2021-05-06 BR BR112022022437A patent/BR112022022437A2/pt unknown
- 2021-05-06 IL IL297963A patent/IL297963A/en unknown
- 2021-05-06 PE PE2022002570A patent/PE20230769A1/es unknown
- 2021-05-06 WO PCT/GB2021/051106 patent/WO2021224636A1/en active Application Filing
- 2021-05-06 AU AU2021266433A patent/AU2021266433A1/en active Pending
- 2021-05-06 KR KR1020227042714A patent/KR20230035236A/ko active Search and Examination
- 2021-05-06 EP EP21726445.6A patent/EP4146654A1/en active Pending
-
2022
- 2022-11-04 CL CL2022003055A patent/CL2022003055A1/es unknown
- 2022-12-01 EC ECSENADI202291613A patent/ECSP22091613A/es unknown
- 2022-12-06 CO CONC2022/0017618A patent/CO2022017618A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20230203041A1 (en) | 2023-06-29 |
CO2022017618A2 (es) | 2023-02-16 |
WO2021224636A1 (en) | 2021-11-11 |
CN115996929A (zh) | 2023-04-21 |
GB2609879B (en) | 2023-08-16 |
GB2609879A (en) | 2023-02-15 |
JP2023525762A (ja) | 2023-06-19 |
MX2022013946A (es) | 2023-02-01 |
PE20230769A1 (es) | 2023-05-09 |
IL297963A (en) | 2023-01-01 |
KR20230035236A (ko) | 2023-03-13 |
AU2021266433A1 (en) | 2022-12-15 |
BR112022022437A2 (pt) | 2023-01-03 |
CL2022003055A1 (es) | 2023-07-07 |
EP4146654A1 (en) | 2023-03-15 |
GB202217519D0 (en) | 2023-01-04 |
CA3181354A1 (en) | 2021-11-11 |
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