ECSP22087664A - Pirfenidona para el tratamiento del coronavirus - Google Patents
Pirfenidona para el tratamiento del coronavirusInfo
- Publication number
- ECSP22087664A ECSP22087664A ECSENADI202287664A ECDI202287664A ECSP22087664A EC SP22087664 A ECSP22087664 A EC SP22087664A EC SENADI202287664 A ECSENADI202287664 A EC SENADI202287664A EC DI202287664 A ECDI202287664 A EC DI202287664A EC SP22087664 A ECSP22087664 A EC SP22087664A
- Authority
- EC
- Ecuador
- Prior art keywords
- virus
- coronavirus
- subject
- pirfenidone
- covid
- Prior art date
Links
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003073 pirfenidone Drugs 0.000 title abstract 4
- 241000711573 Coronaviridae Species 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 abstract 4
- 208000025721 COVID-19 Diseases 0.000 abstract 3
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 abstract 2
- 206010058874 Viraemia Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- 241001678559 COVID-19 virus Species 0.000 abstract 1
- 241000494545 Cordyline virus 2 Species 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 102000008857 Ferritin Human genes 0.000 abstract 1
- 238000008416 Ferritin Methods 0.000 abstract 1
- 108050000784 Ferritin Proteins 0.000 abstract 1
- -1 IL-1β Proteins 0.000 abstract 1
- 102100037850 Interferon gamma Human genes 0.000 abstract 1
- 108010074328 Interferon-gamma Proteins 0.000 abstract 1
- 108090001005 Interleukin-6 Proteins 0.000 abstract 1
- 241000127282 Middle East respiratory syndrome-related coronavirus Species 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 241001493065 dsRNA viruses Species 0.000 abstract 1
- 238000013265 extended release Methods 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000770 proinflammatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063010009P | 2020-04-14 | 2020-04-14 | |
| PCT/US2021/027335 WO2021211745A1 (en) | 2020-04-14 | 2021-04-14 | Pirfenidone for coronavirus treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP22087664A true ECSP22087664A (es) | 2022-12-30 |
Family
ID=78084909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202287664A ECSP22087664A (es) | 2020-04-14 | 2022-11-14 | Pirfenidona para el tratamiento del coronavirus |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230117397A1 (enExample) |
| EP (1) | EP4135671A4 (enExample) |
| JP (1) | JP2023521887A (enExample) |
| KR (1) | KR20230038644A (enExample) |
| CN (1) | CN115916162A (enExample) |
| AU (1) | AU2021254765A1 (enExample) |
| BR (1) | BR112022020821A2 (enExample) |
| CA (1) | CA3175526A1 (enExample) |
| CL (1) | CL2022002843A1 (enExample) |
| CO (1) | CO2022016155A2 (enExample) |
| EC (1) | ECSP22087664A (enExample) |
| IL (1) | IL297296A (enExample) |
| MX (1) | MX2022012986A (enExample) |
| WO (1) | WO2021211745A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| CN114796122B (zh) * | 2022-03-30 | 2023-03-24 | 山东大学 | 一种聚多巴胺载吡菲尼酮纳米粒及其制备方法和应用 |
| JP7845721B2 (ja) * | 2022-04-29 | 2026-04-14 | オーバーシーズ ファーマシューティカルズ リミテッド | ピルフェニドンの経口用持続放出性固形製剤 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU709178B2 (en) * | 1995-09-19 | 1999-08-26 | Intermune, Inc. | Inhibition of tumor necrosis factor alpha |
| US20020028784A1 (en) * | 2000-03-10 | 2002-03-07 | Nest Gary Van | Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences |
| WO2003030720A2 (en) * | 2001-10-09 | 2003-04-17 | The Children's Hospital Of Philadelphia | Materials and methods for preventing or reducing scar formation |
| US20070072181A1 (en) * | 2003-02-28 | 2007-03-29 | Blatt Lawrence M | Combination therapy for treating alphavirus infection and liver fibrosis |
| US20080025986A1 (en) * | 2003-06-06 | 2008-01-31 | Ozes Osman N | Methods of Treating Tnf-Mediated Disorders |
| US7407973B2 (en) * | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| MX2007014114A (es) * | 2005-05-10 | 2008-03-14 | Intermune Inc | Derivados de piridona para modular el sistema de proteina cinasa activada por estres. |
| NZ591443A (en) * | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| CN101088557A (zh) * | 2006-06-12 | 2007-12-19 | 天津市扶素生物技术有限公司 | 用于预防或治疗hiv感染的药用组合物及其应用 |
| US20080287508A1 (en) * | 2007-05-18 | 2008-11-20 | Intermune, Inc. | Altering pharmacokinetics of pirfenidone therapy |
| SG176053A1 (en) * | 2009-05-15 | 2011-12-29 | Intermune Inc | Methods of treating hiv patients with anti-fibrotics |
| CN101972236A (zh) * | 2010-10-13 | 2011-02-16 | 北京诚创康韵医药科技有限公司 | 一种含吡非尼酮的缓释制剂 |
| ES2913095T3 (es) * | 2011-01-31 | 2022-05-31 | Avalyn Pharma Inc | Compuestos de pirfenidona y análogos de piridona en aerosol y usos de los mismos |
| MX2011007675A (es) * | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| WO2013181691A1 (en) * | 2012-06-04 | 2013-12-12 | The Macfarlane Burnet Institute For Medical Research And Public Health Ltd | A method of treatment and compositions useful therefor, screening and prognostic agents and uses therefor |
| EP4491180A1 (en) * | 2014-01-10 | 2025-01-15 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
-
2021
- 2021-04-14 IL IL297296A patent/IL297296A/en unknown
- 2021-04-14 AU AU2021254765A patent/AU2021254765A1/en not_active Abandoned
- 2021-04-14 MX MX2022012986A patent/MX2022012986A/es unknown
- 2021-04-14 EP EP21788910.4A patent/EP4135671A4/en not_active Withdrawn
- 2021-04-14 BR BR112022020821A patent/BR112022020821A2/pt not_active Application Discontinuation
- 2021-04-14 WO PCT/US2021/027335 patent/WO2021211745A1/en not_active Ceased
- 2021-04-14 US US17/918,791 patent/US20230117397A1/en not_active Abandoned
- 2021-04-14 KR KR1020227039706A patent/KR20230038644A/ko active Pending
- 2021-04-14 JP JP2022562668A patent/JP2023521887A/ja active Pending
- 2021-04-14 CN CN202180042472.1A patent/CN115916162A/zh active Pending
- 2021-04-14 CA CA3175526A patent/CA3175526A1/en active Pending
-
2022
- 2022-10-14 CL CL2022002843A patent/CL2022002843A1/es unknown
- 2022-11-11 CO CONC2022/0016155A patent/CO2022016155A2/es unknown
- 2022-11-14 EC ECSENADI202287664A patent/ECSP22087664A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3175526A1 (en) | 2021-10-21 |
| US20230117397A1 (en) | 2023-04-20 |
| EP4135671A1 (en) | 2023-02-22 |
| IL297296A (en) | 2022-12-01 |
| EP4135671A4 (en) | 2024-08-14 |
| WO2021211745A1 (en) | 2021-10-21 |
| BR112022020821A2 (pt) | 2022-12-20 |
| CL2022002843A1 (es) | 2023-09-01 |
| MX2022012986A (es) | 2023-03-21 |
| AU2021254765A1 (en) | 2022-12-08 |
| KR20230038644A (ko) | 2023-03-21 |
| JP2023521887A (ja) | 2023-05-25 |
| CO2022016155A2 (es) | 2022-12-20 |
| CN115916162A (zh) | 2023-04-04 |
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