ECSP22008098A - Compuestos agonistas de gipr - Google Patents

Compuestos agonistas de gipr

Info

Publication number
ECSP22008098A
ECSP22008098A ECSENADI20228098A ECDI202208098A ECSP22008098A EC SP22008098 A ECSP22008098 A EC SP22008098A EC SENADI20228098 A ECSENADI20228098 A EC SENADI20228098A EC DI202208098 A ECDI202208098 A EC DI202208098A EC SP22008098 A ECSP22008098 A EC SP22008098A
Authority
EC
Ecuador
Prior art keywords
compounds
gipr
agonist compounds
useful
treatment
Prior art date
Application number
ECSENADI20228098A
Other languages
English (en)
Inventor
Andrea Renee Geiser
Hongchang Qu
John Lee
Jorge Alsina-Fernandez
William Christopher Roell
Lili Guo
Samantha Grace Lyons Keyser
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP22008098A publication Critical patent/ECSP22008098A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos que tienen actividad en el receptor de polipéptido insulinotrópico dependiente de glucosa (GIP) humano. La presente invención se refiere además a compuestos que tienen una duración de acción prolongada en el receptor de GIP. Tales compuestos pueden ser útiles en el tratamiento de la diabetes, que incluye diabetes mellitus tipo 2 ("T2DM"). Además, los compuestos pueden ser útiles en el tratamiento de la obesidad.
ECSENADI20228098A 2019-08-01 2022-02-01 Compuestos agonistas de gipr ECSP22008098A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962881685P 2019-08-01 2019-08-01

Publications (1)

Publication Number Publication Date
ECSP22008098A true ECSP22008098A (es) 2022-03-31

Family

ID=72145469

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI20228098A ECSP22008098A (es) 2019-08-01 2022-02-01 Compuestos agonistas de gipr

Country Status (23)

Country Link
US (3) US11254721B2 (es)
EP (1) EP4007593A1 (es)
JP (3) JP7230272B2 (es)
KR (2) KR20250065721A (es)
CN (2) CN120040559A (es)
AR (1) AR119471A1 (es)
AU (2) AU2020322784B2 (es)
CA (1) CA3145608A1 (es)
CL (1) CL2022000140A1 (es)
CO (1) CO2022000759A2 (es)
CR (1) CR20220020A (es)
DO (1) DOP2022000025A (es)
EC (1) ECSP22008098A (es)
IL (1) IL289463A (es)
JO (1) JOP20220024A1 (es)
MX (2) MX2022001137A (es)
MY (1) MY205796A (es)
PE (1) PE20220938A1 (es)
PH (1) PH12022550232A1 (es)
SA (1) SA522431576B1 (es)
TW (1) TWI764209B (es)
UA (1) UA129203C2 (es)
WO (1) WO2021021877A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI744579B (zh) * 2017-12-21 2021-11-01 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
WO2020067575A1 (en) * 2018-09-24 2020-04-02 Takeda Pharmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
AR119471A1 (es) * 2019-08-01 2021-12-22 Lilly Co Eli Compuestos agonistas de gipr
TWI901926B (zh) * 2020-12-18 2025-10-21 美商美國禮來大藥廠 雙重澱粉素及降鈣素受體促效劑及其用途
WO2022159395A1 (en) 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
EP4345105A4 (en) * 2021-06-01 2025-04-23 Nanjing Zhihe Medicine Technology Co., Ltd Polypeptide derivative with dual targeted activation of GLP-1R and GIPR, manufacturing process therefor and use thereof
IL311411A (en) 2021-09-15 2024-05-01 Viking Therapeutics Inc Preparations and methods for the treatment of metabolic and liver disorders
US20250000948A1 (en) 2021-11-15 2025-01-02 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4180060A1 (en) 2021-11-15 2023-05-17 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4299057A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and an acylated amino acid
EP4299052A1 (en) 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and a permeation enhancer
EP4299071A1 (en) 2022-07-01 2024-01-03 Adocia Compositions comprising a peptide or a protein and an acylated amino acid
CA3266547A1 (en) 2022-08-29 2024-03-07 Eli Lilly And Company COMPOSITIONS FOR ORAL ADMINISTRATION
CN120019167A (zh) * 2022-10-12 2025-05-16 首尔大学医院 利用gipr标记物的用于预测磺酰脲类依赖性的组合物及其预测方法
KR102679905B1 (ko) * 2022-10-12 2024-07-02 서울대학교병원 Gipr 마커를 이용한 설폰요소제 의존성 예측용 조성물 및 그 예측 방법
CN121152634A (zh) * 2023-03-31 2025-12-16 伊莱利利公司 用于治疗恶心和呕吐的方法和用途
CN116410298B (zh) * 2023-06-06 2023-08-11 诺博泰科(成都)生物科技有限公司 一种三激动多肽化合物及其盐、药用组合物、药剂和用途
WO2025154020A1 (en) * 2024-01-19 2025-07-24 Takeda Pharmaceutical Company Limited Improved gip receptor agonist peptide compounds and uses thereof
WO2025154021A1 (en) * 2024-01-19 2025-07-24 Takeda Pharmaceutical Company Limited Improved gip receptor agonist peptide compounds and uses thereof
WO2025161155A1 (zh) * 2024-02-04 2025-08-07 内蒙古博睿精创科技有限公司 一种长效glp-1多肽化合物、组合物及其应用
WO2025259957A1 (en) * 2024-06-14 2025-12-18 Eli Lilly And Company Compositions and methods for improving insulin sensitivity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ702333A (en) 2012-05-03 2017-06-30 Zealand Pharma As Gip-glp-1 dual agonist compounds and methods
RU2716985C2 (ru) * 2014-10-29 2020-03-17 Зилэнд Фарма А/С Соединения-агонисты gip и способы
JO3575B1 (ar) * 2015-01-09 2020-07-05 Lilly Co Eli مركبات مساعد مشترك من gip وglp-1
AR110301A1 (es) * 2016-12-02 2019-03-13 Sanofi Sa Compuestos como agonistas peptídicos de receptores de glp1 / glucagón / gip
JOP20190211A1 (ar) 2017-03-31 2019-09-15 Takeda Pharmaceuticals Co ببتيد منشط لمستقبل gip
TWI810937B (zh) * 2017-12-21 2023-08-01 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
TWI735917B (zh) * 2018-07-23 2021-08-11 美商美國禮來大藥廠 Gip/glp1共促效劑化合物
WO2020067575A1 (en) 2018-09-24 2020-04-02 Takeda Pharmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
JP2022503793A (ja) 2018-09-24 2022-01-12 武田薬品工業株式会社 Ｇｉｐ受容体アゴニストペプチド化合物及びその使用
AR119471A1 (es) * 2019-08-01 2021-12-22 Lilly Co Eli Compuestos agonistas de gipr

Also Published As

Publication number Publication date
JP2023062068A (ja) 2023-05-02
JP2022544061A (ja) 2022-10-17
MX2026002524A (es) 2026-04-01
PE20220938A1 (es) 2022-05-31
AU2025203018A1 (en) 2025-07-17
KR20220028007A (ko) 2022-03-08
CR20220020A (es) 2022-02-14
CO2022000759A2 (es) 2022-02-07
AU2020322784A1 (en) 2022-02-03
US11897926B2 (en) 2024-02-13
JP2024150523A (ja) 2024-10-23
JOP20220024A1 (ar) 2023-01-30
PH12022550232A1 (en) 2023-01-04
CL2022000140A1 (es) 2022-09-30
US20240218031A1 (en) 2024-07-04
JP7521027B2 (ja) 2024-07-23
BR112022000027A2 (pt) 2022-05-24
CN114206915A (zh) 2022-03-18
MY205796A (en) 2024-11-13
US20210032299A1 (en) 2021-02-04
AR119471A1 (es) 2021-12-22
TW202126680A (zh) 2021-07-16
CN114206915B (zh) 2025-03-11
UA129203C2 (uk) 2025-02-05
DOP2022000025A (es) 2022-03-15
US20220127315A1 (en) 2022-04-28
AU2020322784B2 (en) 2025-01-30
KR20250065721A (ko) 2025-05-13
EP4007593A1 (en) 2022-06-08
MX2022001137A (es) 2022-02-16
WO2021021877A1 (en) 2021-02-04
TWI764209B (zh) 2022-05-11
US11254721B2 (en) 2022-02-22
CN120040559A (zh) 2025-05-27
JP7230272B2 (ja) 2023-02-28
NZ784648A (en) 2025-08-29
KR102801905B1 (ko) 2025-05-02
IL289463A (en) 2022-02-01
SA522431576B1 (ar) 2024-10-29
CA3145608A1 (en) 2021-02-04

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