ECSP20025198A - Conjugados de fármaco-anticuerpo activable anti-cd71 y métodos de uso de estos - Google Patents

Conjugados de fármaco-anticuerpo activable anti-cd71 y métodos de uso de estos

Info

Publication number
ECSP20025198A
ECSP20025198A ECSENADI202025198A ECDI202025198A ECSP20025198A EC SP20025198 A ECSP20025198 A EC SP20025198A EC SENADI202025198 A ECSENADI202025198 A EC SENADI202025198A EC DI202025198 A ECDI202025198 A EC DI202025198A EC SP20025198 A ECSP20025198 A EC SP20025198A
Authority
EC
Ecuador
Prior art keywords
methods
drug
antibody conjugates
activable antibody
activatable antibodies
Prior art date
Application number
ECSENADI202025198A
Other languages
English (en)
Inventor
Sherry L Ralston
Susan E Morgan-Lappe
Shweta Singh
Marvin Robert Leanna
Tracy Henriques
Jonathan Alexander Terrett
Laura Patterson Serwer
Ilaria Badagnani
Jennifer Hope Richardson
Sahana Bose
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of ECSP20025198A publication Critical patent/ECSP20025198A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere en general a anticuerpos activables conjugados que se fijan a CD71 en su forma activa y a métodos para elaborar y usar estos anticuerpos activables conjugados anti-CD71 en una variedad de indicaciones terapéuticas, de diagnóstico y profilácticas.
ECSENADI202025198A 2017-10-14 2020-05-13 Conjugados de fármaco-anticuerpo activable anti-cd71 y métodos de uso de estos ECSP20025198A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762572467P 2017-10-14 2017-10-14

Publications (1)

Publication Number Publication Date
ECSP20025198A true ECSP20025198A (es) 2020-06-30

Family

ID=64110112

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202025198A ECSP20025198A (es) 2017-10-14 2020-05-13 Conjugados de fármaco-anticuerpo activable anti-cd71 y métodos de uso de estos

Country Status (34)

Country Link
US (3) US20190111150A1 (es)
EP (2) EP3834846A1 (es)
JP (2) JP7374891B2 (es)
KR (4) KR102529359B1 (es)
CN (1) CN111278467B (es)
AR (1) AR115178A1 (es)
AU (1) AU2018346969A1 (es)
BR (1) BR112020007302B1 (es)
CA (1) CA3077730A1 (es)
CL (1) CL2020000977A1 (es)
CO (1) CO2020005685A2 (es)
CR (1) CR20200206A (es)
CY (1) CY1123968T1 (es)
DK (1) DK3691692T3 (es)
DO (1) DOP2023000150A (es)
EC (1) ECSP20025198A (es)
ES (1) ES2864013T3 (es)
HR (1) HRP20210436T8 (es)
HU (1) HUE054037T2 (es)
IL (1) IL273586A (es)
LT (1) LT3691692T (es)
MA (1) MA50752B1 (es)
MD (1) MD3691692T2 (es)
MX (1) MX2020003723A (es)
PE (1) PE20210125A1 (es)
PL (1) PL3691692T3 (es)
PT (1) PT3691692T (es)
RS (1) RS61596B1 (es)
RU (2) RU2022111211A (es)
SG (1) SG11202003378WA (es)
SI (1) SI3691692T1 (es)
TW (2) TWI780237B (es)
UY (1) UY37931A (es)
WO (1) WO2019075417A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130116404A1 (en) 2011-11-08 2013-05-09 Case Western Reserve University Targeted non-invasive imaging probes of egfr expressing cells
BR112017023862A2 (pt) * 2015-05-04 2018-07-17 Cytomx Therapeutics Inc anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes
WO2019183633A1 (en) 2018-03-23 2019-09-26 Case Western Reserve Univeristy Psma targeted conjugate compounds and uses thereof
CA3179911A1 (en) * 2020-04-08 2021-10-14 Janssen Biotech, Inc. Compositions and methods for blood-brain barrier delivery
CN115427113A (zh) * 2020-04-09 2022-12-02 西托姆克斯治疗公司 含有可活化抗体的组合物
EP4429654A1 (en) 2021-11-09 2024-09-18 Case Western Reserve University Psma targeted conjugate compounds and uses thereof
WO2024026474A1 (en) * 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279862B1 (en) 1986-08-28 1993-11-03 Teijin Limited Cytocidal antibody complex and process for its preparation
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
DE69329503T2 (de) 1992-11-13 2001-05-03 Idec Pharma Corp Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma
CA2620886C (en) 2005-08-31 2017-03-14 The Regents Of The University Of California Cellular libraries of peptide sequences (clips) and methods of using the same
AU2008289441A1 (en) 2007-08-22 2009-02-26 Cytomx Therapeutics, Inc. Activatable binding polypeptides and methods of identification and use thereof
NZ585556A (en) * 2007-11-07 2012-07-27 Celldex Therapeutics Inc Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
BRPI1006141B8 (pt) 2009-01-12 2021-05-25 Cytomx Therapeutics Llc composições de anticorpo modificado, métodos para preparar e usar as mesmas
JP5925116B2 (ja) * 2009-04-29 2016-05-25 ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン、インコーポレイテッド Ｅｒｇモノクローナル抗体
WO2010129609A2 (en) 2009-05-07 2010-11-11 The Regents Of The University Of California Antibodies and methods of use thereof
MX350200B (es) * 2011-02-01 2017-08-30 Genmab As Anticuerpos humanos y conjugados de anticuerpo-farmaco contra cd74.
PL3431504T3 (pl) * 2012-01-31 2021-10-18 Sbi Biotech Co., Ltd. Przeciwciało przeciwko fosfolipazie D4
EP2882844B1 (en) 2012-08-10 2018-10-03 Cytomx Therapeutics Inc. Protease-resistant systems for polypeptide display and methods of making and using thereof
CN103145847B (zh) * 2013-02-05 2014-05-21 浙江大学 一种抗cd20抗体-海兔毒素偶联物及其制备方法和应用
PT3088419T (pt) * 2013-12-25 2019-01-11 Daiichi Sankyo Co Ltd Conjugado de anticorpo anti-trop2-fármaco
BR112017023862A2 (pt) * 2015-05-04 2018-07-17 Cytomx Therapeutics Inc anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes
CN106237341B (zh) * 2016-07-12 2019-07-30 浙江大学 一种抗体偶联药物及其制备方法和应用

Also Published As

Publication number Publication date
MA50752B1 (fr) 2021-03-31
KR20230070046A (ko) 2023-05-19
PT3691692T (pt) 2021-03-29
MD3691692T2 (ro) 2021-05-31
SI3691692T1 (sl) 2021-04-30
KR20220045088A (ko) 2022-04-12
CO2020005685A2 (es) 2020-05-15
JP7374891B2 (ja) 2023-11-07
DOP2023000150A (es) 2023-08-31
EP3691692A1 (en) 2020-08-12
HRP20210436T8 (hr) 2022-01-07
RU2020115713A3 (es) 2022-02-25
DK3691692T3 (da) 2021-03-22
KR20200070324A (ko) 2020-06-17
WO2019075417A1 (en) 2019-04-18
RU2020115713A (ru) 2021-11-16
IL273586A (en) 2020-05-31
MA50752A (fr) 2020-08-12
LT3691692T (lt) 2021-05-10
JP2020537649A (ja) 2020-12-24
ES2864013T3 (es) 2021-10-13
JP2024012366A (ja) 2024-01-30
EP3691692B8 (en) 2021-05-26
US20190111150A1 (en) 2019-04-18
RS61596B1 (sr) 2021-04-29
CL2020000977A1 (es) 2020-09-11
MX2020003723A (es) 2020-07-22
TW201927815A (zh) 2019-07-16
KR20230004932A (ko) 2023-01-06
UY37931A (es) 2019-04-30
EP3834846A1 (en) 2021-06-16
US20240115724A1 (en) 2024-04-11
BR112020007302A2 (pt) 2020-09-29
HUE054037T2 (hu) 2021-08-30
CN111278467A (zh) 2020-06-12
TW202330039A (zh) 2023-08-01
CA3077730A1 (en) 2019-04-18
KR102529359B1 (ko) 2023-05-09
HRP20210436T1 (hr) 2021-04-30
CY1123968T1 (el) 2022-05-27
AR115178A1 (es) 2020-12-09
PE20210125A1 (es) 2021-01-19
CR20200206A (es) 2021-02-18
EP3691692B1 (en) 2020-12-30
US20210145978A1 (en) 2021-05-20
CN111278467B (zh) 2024-07-30
BR112020007302B1 (pt) 2023-01-31
KR102385495B1 (ko) 2022-04-15
RU2771292C2 (ru) 2022-04-29
TWI780237B (zh) 2022-10-11
RU2022111211A (ru) 2022-05-05
AU2018346969A1 (en) 2020-04-23
PL3691692T3 (pl) 2021-07-19
SG11202003378WA (en) 2020-05-28

Similar Documents

Publication Publication Date Title
ECSP20025198A (es) Conjugados de fármaco-anticuerpo activable anti-cd71 y métodos de uso de estos
BR112017023862A2 (pt) anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes
AU2018278327A1 (en) Activatable anti-pdl1 antibodies and methods of use thereof
MX2021005116A (es) Anticuerpos activables anti-cd166 y metodos de uso de estos.
CO2018011364A2 (es) Anticuerpos anti-il-33, composiciones, métodos y usos de los mismos
CL2018003758A1 (es) Conjugados anticuerpo anti-dll3-fármaco y métodos de uso. (divisional solicitud 201800458)
ECSP18095014A (es) Proteínas de unión biespecíficas que se unen a una proteína inmunomoduladora y a un antígeno tumoral
CL2019003657A1 (es) Anticuerpos que se unen específicamente a cd38 útiles para mejorar una respuesta inmune en un paciente. (divisional solicitud 201703275)
UY37779A (es) Moléculas de anticuerpo que se unen a cd73 y usos de las mismas
CO2017005650A2 (es) Anticuerpos anti-interleucina-33
MX2022003718A (es) Anticuerpos que se unen a cd39 y sus usos.
BR112018014760A2 (pt) anticorpos anti-ror1, anticorpos biespecíficos para ror1 x cd3 e métodos de uso dos mesmos
CO2018000104A2 (es) Moléculas de anticuerpo que se unen a cd22
BR112017023872A2 (pt) anticorpos anti-cd166, anticorpos anti-cd166 ativáveis e métodos de uso dos mesmos
BR112017023868A2 (pt) anticorpos anti-itga3, anticorpos anti-itga3 ativáveis, e métodos de uso dos mesmos
CR20170251A (es) Anticuerpos anti-c5 y métodos para su uso
CO7151488A2 (es) Anticuerpos de reacción cruzada anti-jagged1/jagged 2, anticuerpos anti-jagged activables y métodos de uso de los mismos
MX2020009861A (es) Anticuerpos contra el complejo principal de histocompatibilidad relacionado con las cadenas a y b clase i (mica) y/o (micb) y sus usos.
AR084315A1 (es) Anticuerpos anti-notch1
CR20170020A (es) Variantes de proteínas de unión al factor h y métodos de uso de estas
CO2019003759A2 (es) Anticuerpos que se unen a la proteína de envoltura del virus zika y usos de los mismos
CL2023001064A1 (es) Proteína de unión al antígeno anti-steap1
UY39337A (es) Anticuerpos anti-abeta
MX2017007209A (es) Prueba y metodo para determinar anticuerpos de produccion de citotoxicidad dependiente del complemento (cdc).
CL2020002459A1 (es) Variantes de anticuerpo c-terminales