ECSP11011030A - Método para tratar o prevenir la trombosis usando etexilato de dabigatrán o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional. - Google Patents
Método para tratar o prevenir la trombosis usando etexilato de dabigatrán o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional.Info
- Publication number
- ECSP11011030A ECSP11011030A EC2011011030A ECSP11011030A ECSP11011030A EC SP11011030 A ECSP11011030 A EC SP11011030A EC 2011011030 A EC2011011030 A EC 2011011030A EC SP11011030 A ECSP11011030 A EC SP11011030A EC SP11011030 A ECSP11011030 A EC SP11011030A
- Authority
- EC
- Ecuador
- Prior art keywords
- warfarine
- thrombosis
- therapy
- prevention
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un método para prevenir el ictus en un paciente que padece fibrilación auricular, en el que el paciente tiene al menos un factor de riesgo para acontecimientos hemorrágicos mayores, comprendiendo el método administrar al paciente 110 mg b.i.d. de etexilato de dabigatrán, opcionalmente en forma de una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11340408P | 2008-11-11 | 2008-11-11 | |
US23755209P | 2009-08-27 | 2009-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP11011030A true ECSP11011030A (es) | 2011-07-29 |
Family
ID=41463076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2011011030A ECSP11011030A (es) | 2008-11-11 | 2011-05-04 | Método para tratar o prevenir la trombosis usando etexilato de dabigatrán o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional. |
Country Status (21)
Country | Link |
---|---|
US (3) | US8962574B2 (es) |
EP (1) | EP2358368A1 (es) |
JP (1) | JP2013510072A (es) |
KR (1) | KR20110086700A (es) |
CN (2) | CN102209544A (es) |
AR (1) | AR074313A1 (es) |
AU (1) | AU2009315729A1 (es) |
BR (1) | BRPI0921479A2 (es) |
CA (1) | CA2738883A1 (es) |
CL (1) | CL2011000798A1 (es) |
CO (1) | CO6361938A2 (es) |
EA (1) | EA201100756A1 (es) |
EC (1) | ECSP11011030A (es) |
IL (1) | IL211852A0 (es) |
MA (1) | MA32786B1 (es) |
MX (1) | MX2011004614A (es) |
NZ (1) | NZ592616A (es) |
PE (1) | PE20110431A1 (es) |
TN (1) | TN2011000228A1 (es) |
TW (1) | TW201022237A (es) |
WO (1) | WO2010055021A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ592616A (en) | 2008-11-11 | 2013-04-26 | Boehringer Ingelheim Int | Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy |
WO2012122024A2 (en) * | 2011-03-04 | 2012-09-13 | Russell Medford | Screening method for identifying patients at risk of drug induced liver injury |
WO2013092497A1 (en) * | 2011-12-22 | 2013-06-27 | Boehringer Ingelheim International Gmbh | Immediate release multi unit pellet system |
WO2014001220A1 (en) | 2012-06-25 | 2014-01-03 | Boehringer Ingelheim International Gmbh | Method for prevention of stroke |
EP2722033A1 (en) * | 2012-10-19 | 2014-04-23 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical Compositions of Dabigatran Free Base |
WO2014060561A1 (en) * | 2012-10-19 | 2014-04-24 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Oral pharmaceutical formulations comprising dabigatran |
CN103788063B (zh) * | 2012-10-29 | 2016-01-20 | 天津药物研究院 | 四水合达比加群酯晶体及其制备方法和药物用途 |
IN2013CH05441A (es) * | 2013-11-26 | 2015-05-29 | Aurobindo Pharma Ltd | |
CN104291789B (zh) * | 2014-09-28 | 2016-03-02 | 定远县绿苑新型建材有限公司 | 一种吸水性强的多孔砖及其制备方法 |
CN105560236B (zh) * | 2014-10-30 | 2019-03-15 | 成都百裕制药股份有限公司 | 一种含有银杏内酯b和非肽类凝血酶抑制剂的药物组合物及其制备方法和用途 |
CN108133754B (zh) * | 2017-12-19 | 2019-03-12 | 中国医学科学院阜外医院 | 一种溶栓后出血风险的预测系统 |
CN110339193B (zh) | 2018-04-04 | 2022-04-29 | 上海汉都医药科技有限公司 | 含达比加群酯的药物组合物及其制备方法 |
US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
CN111983085B (zh) * | 2020-08-21 | 2022-05-31 | 江苏省食品药品监督检验研究院 | 一组血清代谢标志物在预测华法林个体药效和指导华法林个体化用药中的应用 |
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BRPI0915942A2 (pt) | 2008-07-14 | 2019-04-09 | Boehringer Ingelheim International Gmbh | método para produção de compostos medicinais contendo dabigatrana |
WO2010020600A1 (en) | 2008-08-19 | 2010-02-25 | Boehringer Ingelheim International Gmbh | Use of dabigatranetexilate for treating patients with pulmonary hypertension |
JP2012500244A (ja) | 2008-08-19 | 2012-01-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 腫瘍療法におけるダビガトラン |
KR20110044230A (ko) | 2008-08-19 | 2011-04-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 경피적 중재 심장 카테터 삽입을 위한 다비가트란 |
NZ592616A (en) | 2008-11-11 | 2013-04-26 | Boehringer Ingelheim Int | Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy |
BRPI0921353A2 (pt) | 2008-11-11 | 2015-12-29 | Boehringer Ingelheim Int | método para tratamento ou prevenção de trombose usando etexilato de dabigatran ou um sal do mesmo com eficácia aperfeiçoada com relação á terapia com warfarina convencional. |
CN102209546A (zh) | 2008-11-11 | 2011-10-05 | 贝林格尔.英格海姆国际有限公司 | 使用达比加群酯或其盐治疗或预防血栓形成且与常规的华法林疗法相比具有改良有效性的方法 |
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-
2009
- 2009-11-10 NZ NZ592616A patent/NZ592616A/xx not_active IP Right Cessation
- 2009-11-10 CN CN2009801442124A patent/CN102209544A/zh active Pending
- 2009-11-10 US US13/128,459 patent/US8962574B2/en active Active
- 2009-11-10 CN CN2013101863297A patent/CN103356614A/zh active Pending
- 2009-11-10 BR BRPI0921479A patent/BRPI0921479A2/pt not_active IP Right Cessation
- 2009-11-10 TW TW098138131A patent/TW201022237A/zh unknown
- 2009-11-10 PE PE2011001005A patent/PE20110431A1/es not_active Application Discontinuation
- 2009-11-10 WO PCT/EP2009/064873 patent/WO2010055021A1/en active Application Filing
- 2009-11-10 AR ARP090104346A patent/AR074313A1/es unknown
- 2009-11-10 CA CA2738883A patent/CA2738883A1/en not_active Abandoned
- 2009-11-10 MX MX2011004614A patent/MX2011004614A/es not_active Application Discontinuation
- 2009-11-10 AU AU2009315729A patent/AU2009315729A1/en not_active Abandoned
- 2009-11-10 EA EA201100756A patent/EA201100756A1/ru unknown
- 2009-11-10 EP EP09756704A patent/EP2358368A1/en not_active Withdrawn
- 2009-11-10 JP JP2011535124A patent/JP2013510072A/ja active Pending
- 2009-11-10 KR KR1020117010630A patent/KR20110086700A/ko not_active Application Discontinuation
-
2010
- 2010-06-17 US US12/817,347 patent/US20100322869A1/en not_active Abandoned
-
2011
- 2011-03-22 IL IL211852A patent/IL211852A0/en unknown
- 2011-04-11 CL CL2011000798A patent/CL2011000798A1/es unknown
- 2011-05-04 EC EC2011011030A patent/ECSP11011030A/es unknown
- 2011-05-10 TN TN2011000228A patent/TN2011000228A1/fr unknown
- 2011-05-11 MA MA33834A patent/MA32786B1/fr unknown
- 2011-05-11 CO CO11058047A patent/CO6361938A2/es not_active Application Discontinuation
-
2012
- 2012-07-13 US US13/548,423 patent/US20120282187A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ592616A (en) | 2013-04-26 |
IL211852A0 (en) | 2011-06-30 |
CA2738883A1 (en) | 2010-05-20 |
US20100322869A1 (en) | 2010-12-23 |
US20110269703A1 (en) | 2011-11-03 |
CO6361938A2 (es) | 2012-01-20 |
JP2013510072A (ja) | 2013-03-21 |
KR20110086700A (ko) | 2011-07-29 |
CL2011000798A1 (es) | 2012-01-27 |
PE20110431A1 (es) | 2011-07-13 |
MA32786B1 (fr) | 2011-11-01 |
BRPI0921479A2 (pt) | 2016-01-12 |
TW201022237A (en) | 2010-06-16 |
CN102209544A (zh) | 2011-10-05 |
CN103356614A (zh) | 2013-10-23 |
US8962574B2 (en) | 2015-02-24 |
MX2011004614A (es) | 2011-05-31 |
AU2009315729A1 (en) | 2010-05-20 |
US20120282187A1 (en) | 2012-11-08 |
TN2011000228A1 (en) | 2012-12-17 |
EP2358368A1 (en) | 2011-08-24 |
WO2010055021A1 (en) | 2010-05-20 |
AR074313A1 (es) | 2011-01-05 |
EA201100756A1 (ru) | 2011-12-30 |
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