CL2009000803A1 - Uso de una variante de igf-1 pegilada para tratar, prevenir un trastorno neuromuscular; metodo para el tratamiento, prevencion y/o demora de un trastorno neuromuscular; composicion que comprende la variante de igf-1 modificada - Google Patents
Uso de una variante de igf-1 pegilada para tratar, prevenir un trastorno neuromuscular; metodo para el tratamiento, prevencion y/o demora de un trastorno neuromuscular; composicion que comprende la variante de igf-1 modificadaInfo
- Publication number
- CL2009000803A1 CL2009000803A1 CL2009000803A CL2009000803A CL2009000803A1 CL 2009000803 A1 CL2009000803 A1 CL 2009000803A1 CL 2009000803 A CL2009000803 A CL 2009000803A CL 2009000803 A CL2009000803 A CL 2009000803A CL 2009000803 A1 CL2009000803 A1 CL 2009000803A1
- Authority
- CL
- Chile
- Prior art keywords
- variant
- igf
- neuromuscular disorder
- treat
- prevention
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
Abstract
Uso de una variante de igf-1 pegilada para tratar, prevenir un trastorno neuromuscular; método para el tratamiento, prevención y/o demora de un transtorno neuromuscular; composición que comprende la variante de igf-1 modificada.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08153994 | 2008-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000803A1 true CL2009000803A1 (es) | 2010-05-07 |
Family
ID=41021043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000803A CL2009000803A1 (es) | 2008-04-03 | 2009-04-02 | Uso de una variante de igf-1 pegilada para tratar, prevenir un trastorno neuromuscular; metodo para el tratamiento, prevencion y/o demora de un trastorno neuromuscular; composicion que comprende la variante de igf-1 modificada |
Country Status (19)
Country | Link |
---|---|
US (5) | US20090253628A1 (es) |
EP (1) | EP2274016B1 (es) |
JP (1) | JP5173018B2 (es) |
KR (1) | KR101273187B1 (es) |
CN (1) | CN101983074A (es) |
AR (1) | AR071574A1 (es) |
AU (1) | AU2009231394B2 (es) |
BR (1) | BRPI0910338A2 (es) |
CA (1) | CA2720408C (es) |
CL (1) | CL2009000803A1 (es) |
CR (1) | CR11692A (es) |
EC (1) | ECSP10010516A (es) |
ES (1) | ES2388827T3 (es) |
IL (1) | IL208106A (es) |
MX (1) | MX2010010495A (es) |
PE (1) | PE20091715A1 (es) |
RU (1) | RU2010144014A (es) |
TW (1) | TW200944237A (es) |
WO (1) | WO2009121759A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1674113A1 (en) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
KR101106795B1 (ko) | 2006-08-31 | 2012-01-18 | 에프. 호프만-라 로슈 아게 | 인슐린-유사 성장 인자-i의 제조 방법 |
CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
CN101965516A (zh) * | 2008-04-03 | 2011-02-02 | 弗·哈夫曼-拉罗切有限公司 | 聚乙二醇化胰岛素样生长因子测定 |
US20110152188A1 (en) | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
WO2012178146A1 (en) * | 2011-06-24 | 2012-12-27 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of spinal muscular atrophy |
KR102499918B1 (ko) * | 2012-10-24 | 2023-02-14 | 다이이찌 산쿄 가부시키가이샤 | 근위축성 측삭 경화증 치료제 |
CN105792839A (zh) | 2013-10-02 | 2016-07-20 | 诺华股份有限公司 | 用于治疗的胰岛素样生长因子拟似物 |
UY35874A (es) | 2013-12-12 | 2015-07-31 | Novartis Ag | Un proceso para la preparación de una composición de proteínas pegiladas |
AU2018276554A1 (en) | 2017-05-30 | 2019-10-10 | Teijin Pharma Limited | Anti-IGF-I receptor antibody |
AU2018317807A1 (en) * | 2017-08-16 | 2020-02-06 | Roxiant ApS | VTFT isoform of a BPIFB4 protein for use in neuronal diseases and injuries |
BR112021010479A2 (pt) | 2018-12-03 | 2021-11-16 | Teijin Pharma Ltd | Anticorpo humanizado anti-receptor de igf-i ou fragmento ou derivado do mesmo, molécula de ácido nucleico, vetor de clonagem ou vetor de expressão, célula recombinante, processo para produção de um anticorpo humanizado anti-receptor de igf-i ou fragmento ou derivado do mesmo, e, composição farmacêutica |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
US5135956A (en) * | 1988-10-18 | 1992-08-04 | The Regents Of The University Of California | Method of using cytoprotective alcohols to treat neural disease and neural injury |
US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
US5158875A (en) * | 1989-08-25 | 1992-10-27 | Amgen Inc. | Production of biologically active insulin-like growth factor i from high expression host cell systems |
NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
US5861373A (en) * | 1991-08-01 | 1999-01-19 | Genentech, Inc | IGF-1 to improve the neural condition |
ATE151293T1 (de) * | 1991-08-01 | 1997-04-15 | Genentech Inc | Igf-i zur verbesserung der neuronale lage |
FR2688138B1 (fr) * | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
US5395822A (en) * | 1993-09-20 | 1995-03-07 | Izumi; Yukitoshi | Use of pyruvate to prevent neuronal degeneration associated with ischemia |
WO1995032003A1 (en) * | 1994-05-24 | 1995-11-30 | Amgen Boulder Inc. | Modified insulin-like growth factors |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US5906976A (en) * | 1996-10-22 | 1999-05-25 | Ramot-University Authority For Applied Research And Industrial Development, Ltd. | Method and composition for treating neuronal degeneration |
AU762047B2 (en) * | 1999-01-06 | 2003-06-19 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
ATE284415T1 (de) * | 1999-01-06 | 2004-12-15 | Genentech Inc | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
US20040014652A1 (en) * | 2000-06-01 | 2004-01-22 | Andre Trouet | Tumor activated prodrug compounds and methods of making and using the same |
EP1674113A1 (en) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
AR059088A1 (es) * | 2006-01-20 | 2008-03-12 | Genzyme Corp | Administracion intraventricular de una proteina para esclerosis lateral amiotrofica |
CL2007002502A1 (es) * | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
KR101106795B1 (ko) * | 2006-08-31 | 2012-01-18 | 에프. 호프만-라 로슈 아게 | 인슐린-유사 성장 인자-i의 제조 방법 |
-
2009
- 2009-03-24 JP JP2011502341A patent/JP5173018B2/ja not_active Expired - Fee Related
- 2009-03-24 CN CN2009801121265A patent/CN101983074A/zh active Pending
- 2009-03-24 RU RU2010144014/10A patent/RU2010144014A/ru unknown
- 2009-03-24 CA CA2720408A patent/CA2720408C/en not_active Expired - Fee Related
- 2009-03-24 EP EP09727511A patent/EP2274016B1/en active Active
- 2009-03-24 ES ES09727511T patent/ES2388827T3/es active Active
- 2009-03-24 WO PCT/EP2009/053465 patent/WO2009121759A2/en active Application Filing
- 2009-03-24 AU AU2009231394A patent/AU2009231394B2/en not_active Ceased
- 2009-03-24 KR KR1020107021584A patent/KR101273187B1/ko not_active IP Right Cessation
- 2009-03-24 MX MX2010010495A patent/MX2010010495A/es active IP Right Grant
- 2009-03-24 BR BRPI0910338-4A patent/BRPI0910338A2/pt not_active IP Right Cessation
- 2009-03-26 US US12/411,673 patent/US20090253628A1/en not_active Abandoned
- 2009-04-01 AR ARP090101168A patent/AR071574A1/es unknown
- 2009-04-01 TW TW098110905A patent/TW200944237A/zh unknown
- 2009-04-01 PE PE2009000477A patent/PE20091715A1/es not_active Application Discontinuation
- 2009-04-02 CL CL2009000803A patent/CL2009000803A1/es unknown
-
2010
- 2010-09-13 IL IL208106A patent/IL208106A/en not_active IP Right Cessation
- 2010-09-27 CR CR11692A patent/CR11692A/es not_active Application Discontinuation
- 2010-10-01 EC EC2010010516A patent/ECSP10010516A/es unknown
-
2011
- 2011-04-01 US US13/078,106 patent/US20110183903A1/en not_active Abandoned
-
2013
- 2013-01-17 US US13/743,406 patent/US20140073567A1/en not_active Abandoned
-
2015
- 2015-04-13 US US14/684,772 patent/US20150273023A1/en not_active Abandoned
-
2016
- 2016-07-26 US US15/220,380 patent/US20170014488A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP5173018B2 (ja) | 2013-03-27 |
KR101273187B1 (ko) | 2013-06-17 |
CA2720408A1 (en) | 2009-10-08 |
CR11692A (es) | 2010-12-09 |
US20140073567A1 (en) | 2014-03-13 |
JP2011518778A (ja) | 2011-06-30 |
US20170014488A1 (en) | 2017-01-19 |
US20090253628A1 (en) | 2009-10-08 |
ECSP10010516A (es) | 2010-11-30 |
IL208106A (en) | 2015-09-24 |
BRPI0910338A2 (pt) | 2020-08-18 |
KR20100119816A (ko) | 2010-11-10 |
AR071574A1 (es) | 2010-06-30 |
WO2009121759A3 (en) | 2010-03-25 |
TW200944237A (en) | 2009-11-01 |
US20150273023A1 (en) | 2015-10-01 |
CA2720408C (en) | 2016-09-06 |
CN101983074A (zh) | 2011-03-02 |
PE20091715A1 (es) | 2009-11-17 |
US20110183903A1 (en) | 2011-07-28 |
IL208106A0 (en) | 2010-12-30 |
EP2274016A2 (en) | 2011-01-19 |
EP2274016B1 (en) | 2012-07-25 |
AU2009231394A1 (en) | 2009-10-08 |
WO2009121759A2 (en) | 2009-10-08 |
RU2010144014A (ru) | 2012-05-27 |
ES2388827T3 (es) | 2012-10-19 |
AU2009231394B2 (en) | 2013-09-05 |
MX2010010495A (es) | 2010-10-15 |
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