CO6361938A2 - Metodo para tratar o prevenir la trombosis usando etexilato de dabigatran o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional - Google Patents

Metodo para tratar o prevenir la trombosis usando etexilato de dabigatran o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional

Info

Publication number
CO6361938A2
CO6361938A2 CO11058047A CO11058047A CO6361938A2 CO 6361938 A2 CO6361938 A2 CO 6361938A2 CO 11058047 A CO11058047 A CO 11058047A CO 11058047 A CO11058047 A CO 11058047A CO 6361938 A2 CO6361938 A2 CO 6361938A2
Authority
CO
Colombia
Prior art keywords
warfarine
therapy
treat
improved safety
safety profile
Prior art date
Application number
CO11058047A
Other languages
English (en)
Inventor
Paul A Reilly
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO6361938A2 publication Critical patent/CO6361938A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un método para prevenir el ictus en un paciente que padece fibrilación auricular, en el que el paciente tiene al menos un factor de riesgo para acontecimientos hemorrágicos mayores, comprendiendo el método administrar al paciente 110 mg b.i.d. de etexilato de dabigatrán, opcionalmente en forma de una sal farmacéuticamente aceptable del mismo.
CO11058047A 2008-11-11 2011-05-11 Metodo para tratar o prevenir la trombosis usando etexilato de dabigatran o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional CO6361938A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11340408P 2008-11-11 2008-11-11
US23755209P 2009-08-27 2009-08-27

Publications (1)

Publication Number Publication Date
CO6361938A2 true CO6361938A2 (es) 2012-01-20

Family

ID=41463076

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11058047A CO6361938A2 (es) 2008-11-11 2011-05-11 Metodo para tratar o prevenir la trombosis usando etexilato de dabigatran o una sal del mismo con un perfil de seguridad mejorado sobre la terapia con warfarina convencional

Country Status (21)

Country Link
US (3) US8962574B2 (es)
EP (1) EP2358368A1 (es)
JP (1) JP2013510072A (es)
KR (1) KR20110086700A (es)
CN (2) CN103356614A (es)
AR (1) AR074313A1 (es)
AU (1) AU2009315729A1 (es)
BR (1) BRPI0921479A2 (es)
CA (1) CA2738883A1 (es)
CL (1) CL2011000798A1 (es)
CO (1) CO6361938A2 (es)
EA (1) EA201100756A1 (es)
EC (1) ECSP11011030A (es)
IL (1) IL211852A0 (es)
MA (1) MA32786B1 (es)
MX (1) MX2011004614A (es)
NZ (1) NZ592616A (es)
PE (1) PE20110431A1 (es)
TN (1) TN2011000228A1 (es)
TW (1) TW201022237A (es)
WO (1) WO2010055021A1 (es)

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CN103788063B (zh) * 2012-10-29 2016-01-20 天津药物研究院 四水合达比加群酯晶体及其制备方法和药物用途
IN2013CH05441A (es) * 2013-11-26 2015-05-29 Aurobindo Pharma Ltd
CN104291789B (zh) * 2014-09-28 2016-03-02 定远县绿苑新型建材有限公司 一种吸水性强的多孔砖及其制备方法
CN105560236B (zh) * 2014-10-30 2019-03-15 成都百裕制药股份有限公司 一种含有银杏内酯b和非肽类凝血酶抑制剂的药物组合物及其制备方法和用途
CN108133754B (zh) * 2017-12-19 2019-03-12 中国医学科学院阜外医院 一种溶栓后出血风险的预测系统
CN110339193B (zh) 2018-04-04 2022-04-29 上海汉都医药科技有限公司 含达比加群酯的药物组合物及其制备方法
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
CN111983085B (zh) * 2020-08-21 2022-05-31 江苏省食品药品监督检验研究院 一组血清代谢标志物在预测华法林个体药效和指导华法林个体化用药中的应用

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Also Published As

Publication number Publication date
NZ592616A (en) 2013-04-26
BRPI0921479A2 (pt) 2016-01-12
PE20110431A1 (es) 2011-07-13
TW201022237A (en) 2010-06-16
US8962574B2 (en) 2015-02-24
US20110269703A1 (en) 2011-11-03
WO2010055021A1 (en) 2010-05-20
AU2009315729A1 (en) 2010-05-20
US20100322869A1 (en) 2010-12-23
MA32786B1 (fr) 2011-11-01
CL2011000798A1 (es) 2012-01-27
ECSP11011030A (es) 2011-07-29
JP2013510072A (ja) 2013-03-21
EP2358368A1 (en) 2011-08-24
MX2011004614A (es) 2011-05-31
CN103356614A (zh) 2013-10-23
CA2738883A1 (en) 2010-05-20
KR20110086700A (ko) 2011-07-29
US20120282187A1 (en) 2012-11-08
EA201100756A1 (ru) 2011-12-30
CN102209544A (zh) 2011-10-05
AR074313A1 (es) 2011-01-05
IL211852A0 (en) 2011-06-30
TN2011000228A1 (en) 2012-12-17

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