ECSP11010883A - Procesos para la preparación del metil-éster del ácido 4-oxo-octahidro-indol-1-carbocíclico y derivados del mismo - Google Patents

Procesos para la preparación del metil-éster del ácido 4-oxo-octahidro-indol-1-carbocíclico y derivados del mismo

Info

Publication number
ECSP11010883A
ECSP11010883A EC2011010883A ECSP11010883A ECSP11010883A EC SP11010883 A ECSP11010883 A EC SP11010883A EC 2011010883 A EC2011010883 A EC 2011010883A EC SP11010883 A ECSP11010883 A EC SP11010883A EC SP11010883 A ECSP11010883 A EC SP11010883A
Authority
EC
Ecuador
Prior art keywords
oxo
ester
methyl
octahidro
indol
Prior art date
Application number
EC2011010883A
Other languages
English (en)
Inventor
Murat Acemoglu
Gottfried Sedelmeier
Philipp Lustenberger
Gerhard Penn
Ernst Kuesters
Beate Schmidt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41278189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11010883(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP11010883A publication Critical patent/ECSP11010883A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un proceso para la producción de metil-éster del ácido (3aR,4S,7aR)-4-hidroxi-4-m-tolil-etinil-octahidro-indol-1-carboxílico (I), de enantiómeros de (2-cloro-etil)-(3-oxo-ciclohexil)-alquil-éster del ácido carbámico (II), y de enantiómeros de 1-carbalcoxi-4-ceto-perhidro-indol (III).
EC2011010883A 2008-08-12 2011-03-11 Procesos para la preparación del metil-éster del ácido 4-oxo-octahidro-indol-1-carbocíclico y derivados del mismo ECSP11010883A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8815608P 2008-08-12 2008-08-12

Publications (1)

Publication Number Publication Date
ECSP11010883A true ECSP11010883A (es) 2011-04-29

Family

ID=41278189

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010883A ECSP11010883A (es) 2008-08-12 2011-03-11 Procesos para la preparación del metil-éster del ácido 4-oxo-octahidro-indol-1-carbocíclico y derivados del mismo

Country Status (22)

Country Link
US (1) US8084487B2 (es)
EP (1) EP2315748B1 (es)
JP (1) JP5468608B2 (es)
KR (1) KR101673634B1 (es)
CN (1) CN102119151A (es)
AU (1) AU2009281218B2 (es)
BR (1) BRPI0917492A8 (es)
CA (1) CA2732095C (es)
CL (1) CL2011000296A1 (es)
CO (1) CO6341608A2 (es)
EC (1) ECSP11010883A (es)
ES (1) ES2547269T3 (es)
HK (1) HK1155733A1 (es)
IL (1) IL210835A (es)
MA (1) MA32618B1 (es)
MX (1) MX2011001664A (es)
MY (1) MY151183A (es)
NZ (1) NZ590753A (es)
PE (1) PE20110415A1 (es)
RU (1) RU2513856C2 (es)
WO (1) WO2010018154A1 (es)
ZA (1) ZA201100558B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130274294A1 (en) * 2010-12-20 2013-10-17 David Carcache 4-(Hetero)Aryl-Ethynyl-Octahydro-Indole-1-Esters
EP2668159A1 (en) 2011-01-24 2013-12-04 Novartis AG 4-tolyl-ethynyl-octahydro-indole-1-ester derivatives
EP2650284A1 (en) 2012-04-10 2013-10-16 Merz Pharma GmbH & Co. KGaA Heterocyclic derivatives as metabotropic glutamate receptor modulators
CA3066711A1 (en) 2017-07-31 2019-02-07 Novartis Ag Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use
EP3661501A1 (en) 2017-07-31 2020-06-10 Novartis AG Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use
CA3124931A1 (en) * 2019-01-29 2020-08-06 Novartis Ag The use of an mglur5 antagonist for treating opioid analgesic tolerance
US20230270720A1 (en) 2020-07-17 2023-08-31 Novartis Ag Mavoglurant, a mglur5 antagonist, for use in the treatment in the reduction of opioid use
IL303248A (en) 2020-12-11 2023-07-01 Novartis Ag Use of MGLUR5 antagonists to treat amphetamine addiction
AU2021404023A1 (en) 2020-12-14 2023-06-29 Novartis Ag Use of mglur5 antagonists for treating gambling disorder

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128996D0 (en) * 2001-12-04 2002-01-23 Novartis Ag Organic compounds
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
EP2069305A2 (en) * 2006-09-11 2009-06-17 Novartis AG Nicotinic acid derivatives as modulators of metabotropic glutamate receptors
RU2508107C2 (ru) * 2007-10-12 2014-02-27 Новартис Аг Модуляторы метаботропного глутаматного рецептора для лечения болезни паркинсона
CA2729595C (en) * 2008-06-30 2017-01-03 Novartis Ag Combinations comprising mglur modulators for the treatment of parkinson's disease

Also Published As

Publication number Publication date
JP5468608B2 (ja) 2014-04-09
CA2732095C (en) 2017-04-25
IL210835A0 (en) 2011-04-28
EP2315748A1 (en) 2011-05-04
US20110144352A1 (en) 2011-06-16
CN102119151A (zh) 2011-07-06
KR101673634B1 (ko) 2016-11-07
US8084487B2 (en) 2011-12-27
PE20110415A1 (es) 2011-07-04
MA32618B1 (fr) 2011-09-01
CL2011000296A1 (es) 2011-11-04
AU2009281218B2 (en) 2013-05-16
CO6341608A2 (es) 2011-11-21
RU2011108663A (ru) 2012-09-20
MY151183A (en) 2014-04-30
IL210835A (en) 2016-05-31
NZ590753A (en) 2012-06-29
AU2009281218A1 (en) 2010-02-18
RU2513856C2 (ru) 2014-04-20
ES2547269T3 (es) 2015-10-05
BRPI0917492A8 (pt) 2016-07-05
BRPI0917492A2 (pt) 2015-08-04
ZA201100558B (en) 2011-10-26
MX2011001664A (es) 2011-03-25
EP2315748B1 (en) 2015-06-24
JP2011530566A (ja) 2011-12-22
KR20110042222A (ko) 2011-04-25
CA2732095A1 (en) 2010-02-18
WO2010018154A1 (en) 2010-02-18
HK1155733A1 (en) 2012-05-25

Similar Documents

Publication Publication Date Title
ECSP11010883A (es) Procesos para la preparación del metil-éster del ácido 4-oxo-octahidro-indol-1-carbocíclico y derivados del mismo
BRPI1014472A8 (pt) Método para produzir um derivado de ácido graxo, microrganismo engenheirado geneticamente, derivado de ácido graxo e composição de biocombustível
CL2012000959A1 (es) Método para preparar éster aril-2-tetrazolil etílico de ácido carbámico que comprende una reducción enzimática enantioselectiva de una arilcetona para formar un compuesto de alcohol de configuración (r) y carbamatar el alcohol; método enzimático para preparar un compuesto de alcohol mediante una reducción por una oxidoreductasa.
ATE517190T1 (de) Verfahren zur fermentativen herstellung von 1,5- diaminopentan
BR112013019181A8 (pt) Dialquil ésteres, plastificante, processo de preparação de um plastificante e usos dos plastificantes
ATE502001T1 (de) Herstellung von essigsäure
DE602007012829D1 (de) Verfahren und zusammensetzungen für ethanolproduzierende cyanobakterien
BRPI0714716B8 (pt) Método para produção de um combustível ou um solvente a partir de uma fonte de ácido graxo
FI20106252A0 (fi) Menetelmä ja systeemi polttoainekomponenttien valmistamiseksi
AR062148A1 (es) Proceso quimico para la preparacion de intermediarios
ITMI20081164A1 (it) Processo per la produzione di esteri dell'acido levulinico da biomasse
UA111142C2 (uk) Одержання заміщених похідних 2-фторакрилової кислоти
EA201101213A1 (ru) Композиции и способы деградации лигноцеллюлозной биомассы
BRPI1008300A8 (pt) processo de purificação de daptomicina
ATE373681T1 (de) Ester von hyaluronsäure mit rhein, herstellungsverfahren dafür und zusammensetzungen damit
EA200970247A1 (ru) Способ получения оптического активного n-защищенного 3-аминопирролидина или оптически активного n-защищенного 3-аминопиперидина и соответствующих кетонов путем оптического разделения рацемических смесей аминов с использованием бактериальной омега-трансаминазы
WO2009035689A3 (en) Biofuel composition and manufacturing process
CL2012000560A1 (es) Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).
EA201391481A1 (ru) Аналоги эпоксиэйкозатриеновой кислоты и способы их получения и использования
ATE530660T1 (de) Enzymatische herstellung von (meth)acrylsäureestern
BR112013018857A2 (pt) processo para a produção dos ésteres de álcool dos ácidos graxos e composição do processo de fermentação do álcool
BRPI0817747A8 (pt) Processo para a preparação de derivados de ácido 2-di-halogenoacil-3-amino-acrílico
BR112013004164A2 (pt) processo para a preparação de intermediários para a produção de inibidores da nep
BR112014026053A2 (pt) método de preparo de para-xileno a partir de biomassa
CO6310998A2 (es) Composiciones anfifilicas que comprenden un grupo hidrofilo y un grupo hidrofobo y proceso para su produccion