ECSP10010375A - Paramixovirus oncolíticos atenuados que codifican citoquinas de aves - Google Patents
Paramixovirus oncolíticos atenuados que codifican citoquinas de avesInfo
- Publication number
- ECSP10010375A ECSP10010375A EC2010010375A ECSP10010375A ECSP10010375A EC SP10010375 A ECSP10010375 A EC SP10010375A EC 2010010375 A EC2010010375 A EC 2010010375A EC SP10010375 A ECSP10010375 A EC SP10010375A EC SP10010375 A ECSP10010375 A EC SP10010375A
- Authority
- EC
- Ecuador
- Prior art keywords
- virus
- bird
- disease
- oncolytic
- rna
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18141—Use of virus, viral particle or viral elements as a vector
- C12N2760/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18161—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La invención se refiere a un virus a ARN oncolítico recombinante de la enfermedad de Newcastle para el tratamiento de una enfermedad proliferativa, que comprende al menos un transgen que codifica una citoquina de aves, en donde el virus a ARN oncolítico recombinante de la enfermedad de Newcastle se puede obtener a partir de un virus a ARN de la enfermedad de Newcastle oncolítico velogénico o mesogénico. La expresión mediada por virus de la citoquina en las células huésped natural conduce a una patogenicidad reducida del virus para especies de aves. Aún más, el genoma del virus puede codificar proteínas de unión, enzimas convertidoras de prodrogas o/y proteasas. La expresión selectiva de estas moléculas en célula tumorales infectadas con virus incrementa el efecto antitumoral del virus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2433308P | 2008-01-29 | 2008-01-29 | |
EP08001643A EP2085092A1 (en) | 2008-01-29 | 2008-01-29 | Attenuated oncolytic paramyxoviruses encoding avian cytokines |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP10010375A true ECSP10010375A (es) | 2010-08-31 |
Family
ID=39708421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2010010375A ECSP10010375A (es) | 2008-01-29 | 2010-07-29 | Paramixovirus oncolíticos atenuados que codifican citoquinas de aves |
Country Status (22)
Country | Link |
---|---|
US (1) | US20100092430A1 (es) |
EP (2) | EP2085092A1 (es) |
JP (1) | JP2011510638A (es) |
KR (1) | KR20100113096A (es) |
CN (1) | CN102099045A (es) |
AR (1) | AR070272A1 (es) |
AU (1) | AU2009210301A1 (es) |
BR (1) | BRPI0906354A2 (es) |
CA (1) | CA2711571A1 (es) |
CL (1) | CL2009000190A1 (es) |
CO (1) | CO6290693A2 (es) |
CR (1) | CR11616A (es) |
DO (1) | DOP2010000233A (es) |
EA (1) | EA201001202A1 (es) |
EC (1) | ECSP10010375A (es) |
IL (1) | IL206382A0 (es) |
MX (1) | MX2010008370A (es) |
PA (1) | PA8813901A1 (es) |
PE (1) | PE20091355A1 (es) |
TW (1) | TW200936159A (es) |
WO (1) | WO2009095167A1 (es) |
ZA (1) | ZA201006151B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9387242B2 (en) | 2005-12-02 | 2016-07-12 | Icahn School Of Medicine At Mount Sinai | Chimeric viruses presenting non-native surface proteins and uses thereof |
US8591881B2 (en) | 2009-02-05 | 2013-11-26 | Mount Sinai School Of Medicine | Chimeric Newcastle disease viruses and uses thereof |
US9937196B2 (en) * | 2009-06-19 | 2018-04-10 | University Of Maryland, College Park | Genomic sequence of avian paramyxovirus type 2 and uses thereof |
CN103732236B (zh) * | 2011-08-05 | 2017-09-15 | 新罗杰公司 | 用于生产痘苗病毒的方法和组合物 |
AU2014241843B2 (en) * | 2013-03-14 | 2019-05-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
US10519426B2 (en) | 2013-09-03 | 2019-12-31 | Medimmune Limited | Compositions featuring an attenuated Newcastle disease virus and methods of use for treating neoplasia |
KR102407019B1 (ko) | 2014-02-27 | 2022-06-08 | 머크 샤프 앤드 돔 코포레이션 | 암의 치료를 위한 결합 방법 |
GB201505860D0 (en) * | 2015-04-07 | 2015-05-20 | Agalimmune Ltd | Therapeutic compositions and methods of use for treating cancer |
CN108362875A (zh) * | 2018-01-10 | 2018-08-03 | 华南农业大学 | 一种鉴别新城疫感染与免疫的间接elisa方法 |
CN111094324B (zh) * | 2018-03-14 | 2023-10-10 | 武汉博威德生物技术有限公司 | 一种溶瘤病毒、合成dna序列及其应用 |
TW202043466A (zh) * | 2019-01-25 | 2020-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 編碼ccl21之重組棒狀病毒 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT702085E (pt) | 1994-07-18 | 2004-04-30 | Karl Klaus Conzelmann | Virus de arn de cadeia negativa nao segmentada infeccioso recombinante |
US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
MXPA01010393A (es) | 1999-04-15 | 2004-04-02 | Pro Virus Inc | Tratamiento de neoplasmas con virus. |
US20030224017A1 (en) | 2002-03-06 | 2003-12-04 | Samal Siba K. | Recombinant Newcastle disease viruses useful as vaccines or vaccine vectors |
WO2000067786A1 (en) | 1999-05-05 | 2000-11-16 | University Of Maryland | PRODUCTION OF NOVEL NEWCASTLE DISEASE VIRUS STRAINS FROM cDNAS AND IMPROVED LIVE ATTENUATED NEWCASTLE DISEASE VACCINES |
DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
CA2312626A1 (en) | 1999-07-27 | 2001-01-27 | Akzo Nobel N.V. | A recombinant newcastle disease virus as an embryo vaccine |
US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
WO2001020989A1 (en) | 1999-09-22 | 2001-03-29 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
AU2481502A (en) | 2000-11-02 | 2002-05-15 | Akzo Nobel Nv | A recombinant newcastle disease virus nucleoprotein mutant as a marker vaccine |
EP1411880B1 (en) | 2001-07-11 | 2018-04-25 | University of Miami | Recombinant vsv for the treatment of tumor cells |
EP1300157B1 (en) | 2001-10-04 | 2005-10-26 | Centrum voor Onderzoek in Diergeneeskunde en Agrochemie | Attenuated mutant newcastle disease virus strains for in ovo vaccination and their use |
US20040072276A1 (en) | 2002-05-10 | 2004-04-15 | Direvo BioTech AG. | Process for generating sequence-specific proteases by directed evolution and use thereof |
US20050002897A1 (en) | 2003-06-18 | 2005-01-06 | Ulrich Haupts | Biological entities and the pharmaceutical or diagnostic use thereof |
EA013615B1 (ru) | 2004-11-12 | 2010-06-30 | Байер Шеринг Фарма Акциенгезельшафт | Рекомбинантный онколитический парамиксовирус и его применение |
CN1772886A (zh) | 2005-09-02 | 2006-05-17 | 中国农业科学院哈尔滨兽医研究所 | 表达传染性法氏囊病毒VP2基因的重组新城疫LaSota弱毒疫苗株 |
-
2008
- 2008-01-29 EP EP08001643A patent/EP2085092A1/en not_active Withdrawn
-
2009
- 2009-01-20 EP EP09704993A patent/EP2237790A1/en not_active Withdrawn
- 2009-01-20 CN CN2009801035310A patent/CN102099045A/zh active Pending
- 2009-01-20 MX MX2010008370A patent/MX2010008370A/es not_active Application Discontinuation
- 2009-01-20 EA EA201001202A patent/EA201001202A1/ru unknown
- 2009-01-20 WO PCT/EP2009/000308 patent/WO2009095167A1/en active Application Filing
- 2009-01-20 BR BRPI0906354A patent/BRPI0906354A2/pt not_active Application Discontinuation
- 2009-01-20 AU AU2009210301A patent/AU2009210301A1/en not_active Abandoned
- 2009-01-20 CA CA2711571A patent/CA2711571A1/en not_active Abandoned
- 2009-01-20 JP JP2010544616A patent/JP2011510638A/ja not_active Withdrawn
- 2009-01-20 KR KR1020107016944A patent/KR20100113096A/ko not_active Application Discontinuation
- 2009-01-23 TW TW098103098A patent/TW200936159A/zh unknown
- 2009-01-28 AR ARP090100255A patent/AR070272A1/es unknown
- 2009-01-28 US US12/361,201 patent/US20100092430A1/en not_active Abandoned
- 2009-01-28 PA PA20098813901A patent/PA8813901A1/es unknown
- 2009-01-29 PE PE2009000128A patent/PE20091355A1/es not_active Application Discontinuation
- 2009-01-29 CL CL2009000190A patent/CL2009000190A1/es unknown
-
2010
- 2010-06-15 IL IL206382A patent/IL206382A0/en unknown
- 2010-07-29 CO CO10092654A patent/CO6290693A2/es not_active Application Discontinuation
- 2010-07-29 DO DO2010000233A patent/DOP2010000233A/es unknown
- 2010-07-29 CR CR11616A patent/CR11616A/es not_active Application Discontinuation
- 2010-07-29 EC EC2010010375A patent/ECSP10010375A/es unknown
- 2010-08-27 ZA ZA2010/06151A patent/ZA201006151B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CR11616A (es) | 2010-09-09 |
PE20091355A1 (es) | 2009-10-04 |
IL206382A0 (en) | 2010-12-30 |
EA201001202A1 (ru) | 2011-02-28 |
US20100092430A1 (en) | 2010-04-15 |
BRPI0906354A2 (pt) | 2019-12-17 |
ZA201006151B (en) | 2012-02-29 |
CA2711571A1 (en) | 2009-08-06 |
CL2009000190A1 (es) | 2010-07-19 |
DOP2010000233A (es) | 2010-08-15 |
EP2237790A1 (en) | 2010-10-13 |
JP2011510638A (ja) | 2011-04-07 |
PA8813901A1 (es) | 2009-08-26 |
AR070272A1 (es) | 2010-03-25 |
TW200936159A (en) | 2009-09-01 |
CN102099045A (zh) | 2011-06-15 |
AU2009210301A1 (en) | 2009-08-06 |
KR20100113096A (ko) | 2010-10-20 |
CO6290693A2 (es) | 2011-06-20 |
EP2085092A1 (en) | 2009-08-05 |
WO2009095167A1 (en) | 2009-08-06 |
MX2010008370A (es) | 2010-08-23 |
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