ECSP088222A - Agonistas de receptores adrenérgicos alfa2c funcionalmente selectivos - Google Patents
Agonistas de receptores adrenérgicos alfa2c funcionalmente selectivosInfo
- Publication number
- ECSP088222A ECSP088222A EC2008008222A ECSP088222A ECSP088222A EC SP088222 A ECSP088222 A EC SP088222A EC 2008008222 A EC2008008222 A EC 2008008222A EC SP088222 A ECSP088222 A EC SP088222A EC SP088222 A ECSP088222 A EC SP088222A
- Authority
- EC
- Ecuador
- Prior art keywords
- alfa2c
- compounds
- selective adrenergic
- functionally selective
- methods
- Prior art date
Links
- 230000001800 adrenalinergic effect Effects 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 239000000048 adrenergic agonist Substances 0.000 abstract 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 abstract 1
- 230000006872 improvement Effects 0.000 abstract 1
- 150000002476 indolines Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En sus muchas realizaciones, la presente invención provee una nueva clase de indolinas como inhibidores de agonistas de receptores adrenérgicos a2C; métodos para la preparación de dichos compuestos; composiciones farmacéuticas que contienen uno o más de dichos compuestos; métodos para la preparación de formulaciones farmacéuticas que comprenden uno o más de dichos compuestos; y métodos de tratamiento, prevención, inhibición o mejoría de una o más afecciones asociadas con los receptores adrenérgicos a2C, empleando dichos compuestos o dichas composiciones farmacéuticas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71139805P | 2005-08-25 | 2005-08-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088222A true ECSP088222A (es) | 2008-03-26 |
Family
ID=37401474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008222A ECSP088222A (es) | 2005-08-25 | 2008-02-25 | Agonistas de receptores adrenérgicos alfa2c funcionalmente selectivos |
Country Status (19)
Country | Link |
---|---|
US (1) | US7803828B2 (es) |
EP (1) | EP1945626B1 (es) |
JP (1) | JP2009506047A (es) |
KR (1) | KR20080039982A (es) |
CN (1) | CN101296920A (es) |
AR (1) | AR056043A1 (es) |
AT (1) | ATE517883T1 (es) |
AU (1) | AU2006283104A1 (es) |
BR (1) | BRPI0615307A2 (es) |
CA (1) | CA2620171A1 (es) |
EC (1) | ECSP088222A (es) |
IL (1) | IL189679A0 (es) |
NO (1) | NO20081426L (es) |
PE (1) | PE20070336A1 (es) |
RU (1) | RU2008110908A (es) |
SG (1) | SG165314A1 (es) |
TW (1) | TWI316515B (es) |
WO (1) | WO2007024944A1 (es) |
ZA (1) | ZA200802453B (es) |
Families Citing this family (68)
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US8003624B2 (en) * | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
JP5099814B2 (ja) * | 2006-02-02 | 2012-12-19 | 田辺三菱製薬株式会社 | 含窒素複素二環式化合物 |
ATE546437T1 (de) | 2006-10-19 | 2012-03-15 | Hoffmann La Roche | Aminomethyl-4-imidazole |
EP2086959B1 (en) | 2006-11-02 | 2011-11-16 | F. Hoffmann-La Roche AG | Substituted 2-imidazoles as modulators of the trace amine associated receptors |
JP2010510184A (ja) | 2006-11-16 | 2010-04-02 | エフ.ホフマン−ラ ロシュ アーゲー | 置換4−イミダゾール類 |
AU2007332641A1 (en) | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR) |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
RU2473545C2 (ru) | 2007-02-02 | 2013-01-27 | Ф.Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 для заболеваний цнс |
JP2010518161A (ja) * | 2007-02-13 | 2010-05-27 | シェーリング コーポレイション | 機能選択性α2Cアドレナリン受容体アゴニストとしてのクロマン誘導体および類似体 |
BRPI0807961A2 (pt) * | 2007-02-13 | 2017-05-16 | Pharmacopeia Llc | agonista de alfa2c adrenorreceptor funcionalmente seletivos. |
EP2398776A1 (en) * | 2007-02-13 | 2011-12-28 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
MX2009008465A (es) | 2007-02-15 | 2009-08-20 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos de taar1. |
WO2009003868A2 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (taars) |
AU2008270444A1 (en) | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
EP2183216A1 (en) | 2007-07-27 | 2010-05-12 | F. Hoffmann-Roche AG | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
CN101784515A (zh) | 2007-08-03 | 2010-07-21 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物 |
EA201000808A1 (ru) * | 2007-11-16 | 2011-04-29 | Ньюраксон, Инк. | Индольные соединения и способы лечения висцеральной боли |
US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
EP2323734A1 (en) * | 2008-08-04 | 2011-05-25 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
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RU2631482C2 (ru) | 2011-07-22 | 2017-09-22 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Композиция |
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RU2014149136A (ru) | 2012-05-08 | 2016-07-10 | Мерк Шарп И Доум Корп. | ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ |
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CA2975997A1 (en) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as rorgammat inhibitors and uses thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK151884C (da) * | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
US5559129A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
FR2735776B1 (fr) * | 1995-06-22 | 1997-07-18 | Synthelabo | Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique |
GB9520150D0 (en) | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
EP2223920A3 (en) * | 1996-06-19 | 2011-09-28 | Aventis Pharma Limited | Substituted azabicyclic compounds |
US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5866579A (en) * | 1997-04-11 | 1999-02-02 | Synaptic Pharmaceutical Corporation | Imidazole and imidazoline derivatives and uses thereof |
US6841684B2 (en) * | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
US20030087962A1 (en) | 1998-10-20 | 2003-05-08 | Omeros Corporation | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation |
TWI283669B (en) * | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
CN101897704B (zh) | 2000-07-14 | 2014-10-29 | 阿勒根公司 | 含有α-2肾上腺素能激动剂的组合物 |
US7091232B2 (en) * | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
ES2222832B1 (es) * | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
JP2008514603A (ja) | 2004-09-24 | 2008-05-08 | アラーガン、インコーポレイテッド | α2アドレナリン作動剤としての4−(ヘテロアリール−メチルおよび置換ヘテロアリール−メチル)−イミダゾール−2−チオン |
US7375219B2 (en) * | 2005-04-13 | 2008-05-20 | Neuraxon, Inc. | Substituted indole compounds having NOS inhibitory activity |
-
2006
- 2006-08-23 AT AT06789950T patent/ATE517883T1/de not_active IP Right Cessation
- 2006-08-23 JP JP2008528106A patent/JP2009506047A/ja active Pending
- 2006-08-23 AR ARP060103665A patent/AR056043A1/es not_active Application Discontinuation
- 2006-08-23 WO PCT/US2006/032911 patent/WO2007024944A1/en active Application Filing
- 2006-08-23 RU RU2008110908/04A patent/RU2008110908A/ru not_active Application Discontinuation
- 2006-08-23 CN CNA2006800394929A patent/CN101296920A/zh active Pending
- 2006-08-23 SG SG201006197-6A patent/SG165314A1/en unknown
- 2006-08-23 US US11/508,458 patent/US7803828B2/en not_active Expired - Fee Related
- 2006-08-23 PE PE2006001022A patent/PE20070336A1/es not_active Application Discontinuation
- 2006-08-23 CA CA002620171A patent/CA2620171A1/en not_active Abandoned
- 2006-08-23 KR KR1020087005897A patent/KR20080039982A/ko not_active Application Discontinuation
- 2006-08-23 BR BRPI0615307-0A patent/BRPI0615307A2/pt not_active IP Right Cessation
- 2006-08-23 AU AU2006283104A patent/AU2006283104A1/en not_active Abandoned
- 2006-08-23 EP EP06789950A patent/EP1945626B1/en active Active
- 2006-08-24 TW TW095131072A patent/TWI316515B/zh not_active IP Right Cessation
-
2008
- 2008-02-21 IL IL189679A patent/IL189679A0/en unknown
- 2008-02-25 EC EC2008008222A patent/ECSP088222A/es unknown
- 2008-03-17 ZA ZA200802453A patent/ZA200802453B/xx unknown
- 2008-03-18 NO NO20081426A patent/NO20081426L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SG165314A1 (en) | 2010-10-28 |
AR056043A1 (es) | 2007-09-12 |
CA2620171A1 (en) | 2007-03-01 |
PE20070336A1 (es) | 2007-04-16 |
US7803828B2 (en) | 2010-09-28 |
CN101296920A (zh) | 2008-10-29 |
BRPI0615307A2 (pt) | 2009-08-04 |
TWI316515B (en) | 2009-11-01 |
US20070099872A1 (en) | 2007-05-03 |
TW200808768A (en) | 2008-02-16 |
ATE517883T1 (de) | 2011-08-15 |
EP1945626A1 (en) | 2008-07-23 |
RU2008110908A (ru) | 2009-09-27 |
KR20080039982A (ko) | 2008-05-07 |
ZA200802453B (en) | 2008-12-31 |
EP1945626B1 (en) | 2011-07-27 |
IL189679A0 (en) | 2008-06-05 |
AU2006283104A1 (en) | 2007-03-01 |
WO2007024944A1 (en) | 2007-03-01 |
JP2009506047A (ja) | 2009-02-12 |
NO20081426L (no) | 2008-05-23 |
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