ECSP088172A - Metodos para tratar la epileptogenesis - Google Patents

Metodos para tratar la epileptogenesis

Info

Publication number
ECSP088172A
ECSP088172A EC2008008172A ECSP088172A ECSP088172A EC SP088172 A ECSP088172 A EC SP088172A EC 2008008172 A EC2008008172 A EC 2008008172A EC SP088172 A ECSP088172 A EC SP088172A EC SP088172 A ECSP088172 A EC SP088172A
Authority
EC
Ecuador
Prior art keywords
group
phenyl
alkyl
methods
subject
Prior art date
Application number
EC2008008172A
Other languages
English (en)
Inventor
Boyu Zhao
Roy E Twyman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37637731&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088172(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP088172A publication Critical patent/ECSP088172A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Esta invención está dirigida a métodos para prevenir, tratar, invertir, inhibir o detener la epileptogénesis en un sujeto, que comprende administrar al sujeto en necesidad del mismo, una cantidad terapéuticamente efectiva de un compuesto seleccionado del grupo que consiste en la Fórmula (I) y la Fórmula (II), o una sal o éster farmacéuticamente aceptable del mismo:en donde el fenilo está sustituido en X con uno a cinco átomos de halógeno, seleccionados del grupo que consiste en flúor, cloro, bromo y yodo y, R1, R2, R3, R4, R5 y R6 se seleccionan de manera independiente del grupo que consiste en hidrógeno y alquilo de C1-C4; en donde el alquilo de C1-C4 está sustituido opcionalmente con fenilo (en donde el fenilo está sustituido opcionalmente con sustituyentes, seleccionados de manera independiente del grupo que consiste en halógeno, alquilo de C1-C4, alcoxi de C1?C4, amino, nitro y ciano).
EC2008008172A 2005-07-12 2008-02-12 Metodos para tratar la epileptogenesis ECSP088172A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69862505P 2005-07-12 2005-07-12

Publications (1)

Publication Number Publication Date
ECSP088172A true ECSP088172A (es) 2008-03-26

Family

ID=37637731

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008172A ECSP088172A (es) 2005-07-12 2008-02-12 Metodos para tratar la epileptogenesis

Country Status (16)

Country Link
US (1) US20070021501A1 (es)
EP (1) EP1906946A2 (es)
JP (1) JP2009501223A (es)
KR (1) KR20080028485A (es)
CN (1) CN101309680A (es)
AR (1) AR054550A1 (es)
AU (1) AU2006269462A1 (es)
BR (1) BRPI0613010A2 (es)
CA (1) CA2615127A1 (es)
EA (1) EA200800295A1 (es)
EC (1) ECSP088172A (es)
IL (1) IL188728A0 (es)
NO (1) NO20080739L (es)
TW (1) TW200744575A (es)
WO (1) WO2007008551A2 (es)
ZA (1) ZA200801402B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102088990A (zh) * 2008-05-16 2011-06-08 阿尔伯维塔公司 癫痫的治疗
US8609849B1 (en) 2010-11-30 2013-12-17 Fox Chase Chemical Diversity Center, Inc. Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
CN109939092B (zh) * 2013-03-12 2022-03-22 比皮艾思药物研发有限公司 用于预防或治疗小儿癫痫和癫痫相关综合征的苯基氨基甲酸酯化合物
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
LT3340971T (lt) * 2015-08-24 2024-04-25 Zogenix International Limited Lennox-gastaut'o sindromo gydymo būdai, naudojant fenfluraminą
CA3016253C (en) * 2016-02-29 2020-12-29 Bio-Pharm Solutions Co., Ltd. Sulfamate derivative compounds, processes for preparing them and their uses
US20190022166A1 (en) * 2017-07-18 2019-01-24 Creative Bio-Peptides Inc. Oral anti-inflammatory peptides to treat epilepsy, seizures and cns disorders
CN109920550A (zh) * 2018-12-25 2019-06-21 天津大学 一种基于dMRI研究青少年肌阵挛性癫痫的方法
CN115501344A (zh) * 2022-09-29 2022-12-23 重庆医科大学 一种铁螯合剂的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313692A (en) * 1958-04-21 1967-04-11 Armour Pharma Method of inducing calming and muscle relaxation with carbamates
US3265728A (en) * 1962-07-18 1966-08-09 Armour Pharma Substituted phenethyl carbamates
US5698588A (en) * 1996-01-16 1997-12-16 Yukong Limited Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
US6104956A (en) * 1996-05-31 2000-08-15 Board Of Trustees Of Southern Illinois University Methods of treating traumatic brain injury by vagus nerve stimulation
ES2197078T3 (es) * 1999-02-09 2004-01-01 University Of Virginia Patent Foundation Compuestos derivados del felbamato.
RU2300372C2 (ru) * 2001-02-27 2007-06-10 Орто-Макнейл Фармасьютикал, Инк. Карбаматы для применения для предотвращения или лечения биполярного расстройства
BR0207832A (pt) * 2001-02-27 2004-06-22 Ortho Mcneil Pharm Inc Compostos de carbamato para uso na prevenção ou tratamento de distúrbio bipolar

Also Published As

Publication number Publication date
CA2615127A1 (en) 2007-01-18
WO2007008551A2 (en) 2007-01-18
WO2007008551A3 (en) 2008-06-19
NO20080739L (no) 2008-04-10
IL188728A0 (en) 2008-11-03
BRPI0613010A2 (pt) 2010-12-14
EA200800295A1 (ru) 2008-12-30
JP2009501223A (ja) 2009-01-15
CN101309680A (zh) 2008-11-19
AU2006269462A1 (en) 2007-01-18
TW200744575A (en) 2007-12-16
AR054550A1 (es) 2007-06-27
EP1906946A2 (en) 2008-04-09
US20070021501A1 (en) 2007-01-25
KR20080028485A (ko) 2008-03-31
ZA200801402B (en) 2009-10-28

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