ECSP088108A - NUEVOS DERIVADOS DE PIRIDO[3',2':4,5]FURO[3,2-d]PIRIMIDINA - Google Patents
NUEVOS DERIVADOS DE PIRIDO[3',2':4,5]FURO[3,2-d]PIRIMIDINAInfo
- Publication number
- ECSP088108A ECSP088108A EC2008008108A ECSP088108A ECSP088108A EC SP088108 A ECSP088108 A EC SP088108A EC 2008008108 A EC2008008108 A EC 2008008108A EC SP088108 A ECSP088108 A EC SP088108A EC SP088108 A ECSP088108 A EC SP088108A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- group
- groups
- alkoxy
- independently
- Prior art date
Links
- JUQAECQBUNODQP-UHFFFAOYSA-N furo[3,2-d]pyrimidine Chemical compound C1=NC=C2OC=CC2=N1 JUQAECQBUNODQP-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- -1 amino, hydroxy Chemical group 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención da a conocer un derivado de piridofuropirimidina de fórmula (I): (I)en la que:G1 representa un grupo seleccionado de -CR6R7- y -O- en el que R6 y R7 representan independientemente átomos de hidrógeno o grupos alquilo C1-4;R1 y R2 se seleccionan independientemente de átomos de hidrógeno y grupos alquilo C1-4;R3 representa un grupo seleccionado de alquilo C1-4, alcoxi C1-4, amino, hidroxi, monoalquil C1-4-amino, dialquil C1-4-amino, cicloalquil C3-8-amino, arilo, heteroarilo y grupos heterocíclicos que contienen N saturados que están unidos al anillo de piridina a través de su átomo de nitrógeno, estando todos ellos opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo constituido por átomos de halógeno y grupos hidroxi, alquilo C1-4, alcoxi C1-4-alquilo C1-4, arilalquilo C1-4, -O(CO)O R8, alcoxi C1-4, -(CO)NR8R9, -CN, -CF3, -NR8R9, -SR8 y -SO2NH2, representando independientemente cada R8 y R9 un átomo de hidrógeno o un grupo alquilo C1-4;R4 y R5 se seleccionan independientemente del grupo constituido por átomos de hidrógeno, grupos alquilo C1-4, grupos hidroxilalquilo C1-4 y grupos de fórmula (II): (II)en la que p y q son enteros seleccionados de 0, 1, 2 y 3; A es un enlace directo o un grupo seleccionado de -CONR14-, -NR14CO-, -O-, -COO-, -OCO-, -S-, -SO- y -SO2-, representando independientemente cada R10, R11, R12, R13 y R14 un átomo de hidrógeno o un grupo alquilo C1-4 y siendo G2 un grupo seleccionado de grupos arilo, heteroarilo, o heterociclilo; estando opcionalmente sustituido el grupo G2 con uno o más sustituyentes seleccionados del grupo constituido por átomos de halógeno y grupos C1-4 alquilo, hidroxi, oxo, alcoxi C1-4-alquilo C1-4, arilalquilo C1-4, -(CO)OR16, alcoxi C1-4, -(CO)NR16R17, -CN, -CF3, -NR16R17, -SR16 y -SO2NH2; representando independientemente cada R16 y R17 un átomo de hidrógeno o un grupo alquilo C1-4,y las sales y N-óxidos farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200501840A ES2281251B1 (es) | 2005-07-27 | 2005-07-27 | Nuevos derivados de pirido (3',2':4,5) furo (3,2-d) pirimidina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088108A true ECSP088108A (es) | 2008-02-20 |
Family
ID=36121512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008108A ECSP088108A (es) | 2005-07-27 | 2008-01-16 | NUEVOS DERIVADOS DE PIRIDO[3',2':4,5]FURO[3,2-d]PIRIMIDINA |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20080221096A1 (es) |
| EP (1) | EP1913003A1 (es) |
| JP (1) | JP2009502832A (es) |
| KR (1) | KR20080039384A (es) |
| CN (1) | CN101263144A (es) |
| AR (1) | AR055999A1 (es) |
| AU (1) | AU2006278857A1 (es) |
| CA (1) | CA2616424A1 (es) |
| EC (1) | ECSP088108A (es) |
| ES (1) | ES2281251B1 (es) |
| IL (1) | IL188724A0 (es) |
| MX (1) | MX2008001034A (es) |
| NO (1) | NO20081009L (es) |
| PE (1) | PE20070237A1 (es) |
| RU (1) | RU2008107030A (es) |
| TW (1) | TW200738730A (es) |
| WO (1) | WO2007017078A1 (es) |
| ZA (1) | ZA200800352B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318941B2 (en) | 2006-07-06 | 2012-11-27 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| EP2226323A1 (en) * | 2009-02-27 | 2010-09-08 | Almirall, S.A. | New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives |
| CN102898432A (zh) * | 2011-07-29 | 2013-01-30 | 山东轩竹医药科技有限公司 | 三并环化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| WO2001083456A1 (fr) * | 2000-04-27 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'heteroaryle condenses |
| WO2002088079A2 (en) * | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| ES2259891B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
| ES2259892B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
-
2005
- 2005-07-27 ES ES200501840A patent/ES2281251B1/es not_active Expired - Fee Related
-
2006
- 2006-07-21 JP JP2008523200A patent/JP2009502832A/ja active Pending
- 2006-07-21 CN CNA2006800338219A patent/CN101263144A/zh active Pending
- 2006-07-21 CA CA002616424A patent/CA2616424A1/en not_active Abandoned
- 2006-07-21 RU RU2008107030/04A patent/RU2008107030A/ru not_active Application Discontinuation
- 2006-07-21 KR KR1020087002113A patent/KR20080039384A/ko not_active Application Discontinuation
- 2006-07-21 US US11/996,781 patent/US20080221096A1/en not_active Abandoned
- 2006-07-21 WO PCT/EP2006/007218 patent/WO2007017078A1/en active Application Filing
- 2006-07-21 EP EP06762762A patent/EP1913003A1/en not_active Withdrawn
- 2006-07-21 AU AU2006278857A patent/AU2006278857A1/en not_active Abandoned
- 2006-07-21 MX MX2008001034A patent/MX2008001034A/es not_active Application Discontinuation
- 2006-07-25 AR ARP060103191A patent/AR055999A1/es unknown
- 2006-07-25 PE PE2006000897A patent/PE20070237A1/es not_active Application Discontinuation
- 2006-07-27 TW TW095127490A patent/TW200738730A/zh unknown
-
2008
- 2008-01-10 IL IL188724A patent/IL188724A0/en unknown
- 2008-01-11 ZA ZA200800352A patent/ZA200800352B/xx unknown
- 2008-01-16 EC EC2008008108A patent/ECSP088108A/es unknown
- 2008-02-27 NO NO20081009A patent/NO20081009L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007017078A1 (en) | 2007-02-15 |
| ES2281251B1 (es) | 2008-08-16 |
| AR055999A1 (es) | 2007-09-12 |
| RU2008107030A (ru) | 2009-09-10 |
| KR20080039384A (ko) | 2008-05-07 |
| ZA200800352B (en) | 2008-12-31 |
| PE20070237A1 (es) | 2007-04-21 |
| EP1913003A1 (en) | 2008-04-23 |
| US20080221096A1 (en) | 2008-09-11 |
| IL188724A0 (en) | 2008-08-07 |
| CA2616424A1 (en) | 2007-02-15 |
| JP2009502832A (ja) | 2009-01-29 |
| NO20081009L (no) | 2008-02-27 |
| MX2008001034A (es) | 2008-03-14 |
| CN101263144A (zh) | 2008-09-10 |
| AU2006278857A1 (en) | 2007-02-15 |
| TW200738730A (en) | 2007-10-16 |
| ES2281251A1 (es) | 2007-09-16 |
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