EA202191210A1 - Способы лечения - Google Patents

Способы лечения

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Publication number
EA202191210A1
EA202191210A1 EA202191210A EA202191210A EA202191210A1 EA 202191210 A1 EA202191210 A1 EA 202191210A1 EA 202191210 A EA202191210 A EA 202191210A EA 202191210 A EA202191210 A EA 202191210A EA 202191210 A1 EA202191210 A1 EA 202191210A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nucleic acid
treatment methods
cell
acid conjugate
delivering
Prior art date
Application number
EA202191210A
Other languages
English (en)
Inventor
Джеймс Хейес
Ричард Дж. Холланд
Адам Джадж
Киэу Монг Лам
Original Assignee
Дженевент Сайенсез Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дженевент Сайенсез Гмбх filed Critical Дженевент Сайенсез Гмбх
Publication of EA202191210A1 publication Critical patent/EA202191210A1/ru

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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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  • Medicinal Preparation (AREA)

Abstract

В изобретении представлены способы и композиции для доставки нуклеиновой кислоты в целевую клетку. Способ включает приведение клетки в контакт с 1) полимером, дестабилизирующим мембрану; и 2) конъюгатом нуклеиновой кислоты. Конъюгат нуклеиновой кислоты включает в себя нацеливающий лиганд, связанный с необязательным линкером и нуклеиновой кислотой.
EA202191210A 2018-11-02 2019-11-04 Способы лечения EA202191210A1 (ru)

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