EA202190871A1 - Способы выделения и размножения клеток - Google Patents
Способы выделения и размножения клетокInfo
- Publication number
- EA202190871A1 EA202190871A1 EA202190871A EA202190871A EA202190871A1 EA 202190871 A1 EA202190871 A1 EA 202190871A1 EA 202190871 A EA202190871 A EA 202190871A EA 202190871 A EA202190871 A EA 202190871A EA 202190871 A1 EA202190871 A1 EA 202190871A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cells
- methods
- interleukin
- reproduction
- isolation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000002955 isolation Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 230000003394 haemopoietic effect Effects 0.000 abstract 3
- 102000003812 Interleukin-15 Human genes 0.000 abstract 2
- 108090000172 Interleukin-15 Proteins 0.000 abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 abstract 2
- 102100030704 Interleukin-21 Human genes 0.000 abstract 2
- 108010002335 Interleukin-9 Proteins 0.000 abstract 2
- 102000000585 Interleukin-9 Human genes 0.000 abstract 2
- 108010074108 interleukin-21 Proteins 0.000 abstract 2
- 229940118526 interleukin-9 Drugs 0.000 abstract 2
- 210000004698 lymphocyte Anatomy 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/24—Gas permeable parts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/99—Serum-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2309—Interleukin-9 (IL-9)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18205287 | 2018-11-08 | ||
| PCT/GB2019/053164 WO2020095058A1 (en) | 2018-11-08 | 2019-11-08 | Methods for isolating and expanding cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190871A1 true EA202190871A1 (ru) | 2021-09-15 |
Family
ID=64270643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190871A EA202190871A1 (ru) | 2018-11-08 | 2019-11-08 | Способы выделения и размножения клеток |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220010277A1 (https=) |
| EP (1) | EP3877509A1 (https=) |
| JP (2) | JP7706361B2 (https=) |
| KR (1) | KR20210111746A (https=) |
| CN (1) | CN113423820A (https=) |
| AU (1) | AU2019374488B2 (https=) |
| BR (1) | BR112021008461A2 (https=) |
| CA (1) | CA3117895A1 (https=) |
| EA (1) | EA202190871A1 (https=) |
| IL (1) | IL282876A (https=) |
| MX (1) | MX2021005481A (https=) |
| PH (1) | PH12021551037A1 (https=) |
| WO (1) | WO2020095058A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| GB202105113D0 (en) | 2021-04-09 | 2021-05-26 | Gammadelta Therapeutics Ltd | Novel method |
| KR20240040799A (ko) | 2021-08-03 | 2024-03-28 | 감마델타 테라퓨틱스 엘티디 | 감마 델타 t 세포 및 이의 조성물의 조작 |
| WO2023194915A1 (en) | 2022-04-04 | 2023-10-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
| GB202204926D0 (en) | 2022-04-04 | 2022-05-18 | Gammadelta Therapeutics Ltd | Method for expanding gammadelta T cells |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6028176A (en) | 1996-07-19 | 2000-02-22 | Bayer Corporation | High-affinity interleukin-4 muteins |
| US6537812B1 (en) | 1998-11-04 | 2003-03-25 | Hemosol Inc. | Methods for the production of TcRγδ+ T cells |
| CN101120083B (zh) | 2003-10-08 | 2013-03-27 | 威尔森沃尔夫制造公司 | 利用透气性材料进行细胞培养的方法及装置 |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| AU2006340750B2 (en) | 2005-11-28 | 2013-03-07 | Zymogenetics, Inc. | IL-21 antagonists |
| US9428567B2 (en) | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
| WO2012129201A1 (en) * | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| CN103635573B (zh) * | 2011-05-19 | 2016-05-11 | 分子医学研究所 | 包含γδT细胞的淋巴细胞系、其组合物及生产方法 |
| AU2015273501B2 (en) * | 2014-06-11 | 2021-01-21 | Polybiocept Gmbh | Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy |
| EP4148124A1 (en) * | 2015-10-30 | 2023-03-15 | Cancer Research Technology Limited | Expansion of non-haematopoietic tissue-resident gamma delta t cells and uses of these cells |
| JOP20190224A1 (ar) * | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| GB201707048D0 (en) | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| WO2018229163A1 (en) * | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
-
2019
- 2019-11-08 KR KR1020217013910A patent/KR20210111746A/ko not_active Ceased
- 2019-11-08 AU AU2019374488A patent/AU2019374488B2/en active Active
- 2019-11-08 EA EA202190871A patent/EA202190871A1/ru unknown
- 2019-11-08 EP EP19801404.5A patent/EP3877509A1/en active Pending
- 2019-11-08 WO PCT/GB2019/053164 patent/WO2020095058A1/en not_active Ceased
- 2019-11-08 BR BR112021008461-4A patent/BR112021008461A2/pt unknown
- 2019-11-08 MX MX2021005481A patent/MX2021005481A/es unknown
- 2019-11-08 US US17/292,414 patent/US20220010277A1/en active Pending
- 2019-11-08 CN CN201980088257.8A patent/CN113423820A/zh active Pending
- 2019-11-08 JP JP2021524445A patent/JP7706361B2/ja active Active
- 2019-11-08 CA CA3117895A patent/CA3117895A1/en active Pending
-
2021
- 2021-05-03 IL IL282876A patent/IL282876A/en unknown
- 2021-05-05 PH PH12021551037A patent/PH12021551037A1/en unknown
-
2024
- 2024-12-05 JP JP2024212486A patent/JP2025038009A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PH12021551037A1 (en) | 2022-01-03 |
| EP3877509A1 (en) | 2021-09-15 |
| AU2019374488B2 (en) | 2026-03-26 |
| KR20210111746A (ko) | 2021-09-13 |
| CA3117895A1 (en) | 2020-05-14 |
| CN113423820A (zh) | 2021-09-21 |
| AU2019374488A1 (en) | 2021-05-27 |
| WO2020095058A1 (en) | 2020-05-14 |
| IL282876A (en) | 2021-06-30 |
| JP2022506836A (ja) | 2022-01-17 |
| JP2025038009A (ja) | 2025-03-18 |
| JP7706361B2 (ja) | 2025-07-11 |
| US20220010277A1 (en) | 2022-01-13 |
| BR112021008461A2 (pt) | 2021-08-03 |
| MX2021005481A (es) | 2021-11-04 |
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