EA202190511A1 - Кристаллический (r)-5-карбамоилпиридин-3-ил-2-метил-4-(3-(трифторметокси)бензил)пиперазин-1-карбоксилат, его композиции и способы применения - Google Patents
Кристаллический (r)-5-карбамоилпиридин-3-ил-2-метил-4-(3-(трифторметокси)бензил)пиперазин-1-карбоксилат, его композиции и способы примененияInfo
- Publication number
- EA202190511A1 EA202190511A1 EA202190511A EA202190511A EA202190511A1 EA 202190511 A1 EA202190511 A1 EA 202190511A1 EA 202190511 A EA202190511 A EA 202190511A EA 202190511 A EA202190511 A EA 202190511A EA 202190511 A1 EA202190511 A1 EA 202190511A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carboxylate
- benzyl
- methyl
- carbamoilpiridin
- trifluorometoxy
- Prior art date
Links
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- RFIOZSIHFNEKFF-UHFFFAOYSA-N piperazine-1-carboxylic acid Chemical compound OC(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-N 0.000 title 1
- XXDVCULQMDDOAX-CYBMUJFWSA-N (5-carbamoylpyridin-3-yl) (2R)-2-methyl-4-[[3-(trifluoromethoxy)phenyl]methyl]piperazine-1-carboxylate Chemical compound O(C(F)(F)F)C1=CC=CC(CN2C[C@H](N(CC2)C(=O)OC2=CC(C(=O)N)=CN=C2)C)=C1 XXDVCULQMDDOAX-CYBMUJFWSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862731014P | 2018-09-13 | 2018-09-13 | |
| PCT/US2019/050771 WO2020056105A1 (en) | 2018-09-13 | 2019-09-12 | Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1-carboxylate, compositions and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190511A1 true EA202190511A1 (ru) | 2021-07-05 |
Family
ID=68069873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190511A EA202190511A1 (ru) | 2018-09-13 | 2019-09-12 | Кристаллический (r)-5-карбамоилпиридин-3-ил-2-метил-4-(3-(трифторметокси)бензил)пиперазин-1-карбоксилат, его композиции и способы применения |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US11053199B2 (enExample) |
| EP (2) | EP4434583B1 (enExample) |
| JP (1) | JP7405840B2 (enExample) |
| KR (1) | KR102844245B1 (enExample) |
| CN (3) | CN118561814A (enExample) |
| AU (1) | AU2019337623B2 (enExample) |
| BR (1) | BR112021004340A2 (enExample) |
| CA (1) | CA3112200A1 (enExample) |
| CL (1) | CL2021000596A1 (enExample) |
| CO (1) | CO2021003295A2 (enExample) |
| DK (1) | DK3849970T3 (enExample) |
| EA (1) | EA202190511A1 (enExample) |
| ES (1) | ES2993173T3 (enExample) |
| FI (1) | FI3849970T3 (enExample) |
| HR (1) | HRP20241294T1 (enExample) |
| HU (1) | HUE068147T2 (enExample) |
| IL (1) | IL281276B2 (enExample) |
| LT (1) | LT3849970T (enExample) |
| MA (1) | MA53607B1 (enExample) |
| MX (1) | MX2021002923A (enExample) |
| MY (2) | MY210363A (enExample) |
| PL (1) | PL3849970T3 (enExample) |
| PT (1) | PT3849970T (enExample) |
| RS (1) | RS65967B1 (enExample) |
| SG (1) | SG11202102143RA (enExample) |
| SI (1) | SI3849970T1 (enExample) |
| SM (1) | SMT202400369T1 (enExample) |
| WO (1) | WO2020056105A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019337623B2 (en) | 2018-09-13 | 2024-12-05 | Celgene Corporation | Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1- carboxylate, compositions and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI385164B (zh) | 2005-02-17 | 2013-02-11 | Astellas Pharma Inc | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (II) |
| EP3099332A4 (en) * | 2014-01-29 | 2017-06-21 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| EP4335848A3 (en) | 2017-03-13 | 2024-06-19 | Lundbeck La Jolla Research Center, Inc. | Dual magl and faah inhibitors |
| AU2019337623B2 (en) | 2018-09-13 | 2024-12-05 | Celgene Corporation | Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1- carboxylate, compositions and methods of use thereof |
-
2019
- 2019-09-12 AU AU2019337623A patent/AU2019337623B2/en active Active
- 2019-09-12 MY MYPI2024007477A patent/MY210363A/en unknown
- 2019-09-12 CA CA3112200A patent/CA3112200A1/en active Pending
- 2019-09-12 CN CN202410683425.0A patent/CN118561814A/zh active Pending
- 2019-09-12 DK DK19778721.1T patent/DK3849970T3/da active
- 2019-09-12 JP JP2021514123A patent/JP7405840B2/ja active Active
- 2019-09-12 PT PT197787211T patent/PT3849970T/pt unknown
- 2019-09-12 MX MX2021002923A patent/MX2021002923A/es unknown
- 2019-09-12 MY MYPI2021001295A patent/MY208901A/en unknown
- 2019-09-12 EA EA202190511A patent/EA202190511A1/ru unknown
- 2019-09-12 SI SI201930824T patent/SI3849970T1/sl unknown
- 2019-09-12 KR KR1020217010747A patent/KR102844245B1/ko active Active
- 2019-09-12 US US16/569,578 patent/US11053199B2/en active Active
- 2019-09-12 HU HUE19778721A patent/HUE068147T2/hu unknown
- 2019-09-12 LT LTEPPCT/US2019/050771T patent/LT3849970T/lt unknown
- 2019-09-12 SG SG11202102143RA patent/SG11202102143RA/en unknown
- 2019-09-12 PL PL19778721.1T patent/PL3849970T3/pl unknown
- 2019-09-12 CN CN202410683444.3A patent/CN118530218A/zh active Pending
- 2019-09-12 FI FIEP19778721.1T patent/FI3849970T3/fi active
- 2019-09-12 HR HRP20241294TT patent/HRP20241294T1/hr unknown
- 2019-09-12 CN CN201980060119.9A patent/CN113227069B/zh active Active
- 2019-09-12 MA MA53607A patent/MA53607B1/fr unknown
- 2019-09-12 RS RS20241039A patent/RS65967B1/sr unknown
- 2019-09-12 BR BR112021004340-3A patent/BR112021004340A2/pt unknown
- 2019-09-12 SM SM20240369T patent/SMT202400369T1/it unknown
- 2019-09-12 WO PCT/US2019/050771 patent/WO2020056105A1/en not_active Ceased
- 2019-09-12 IL IL281276A patent/IL281276B2/en unknown
- 2019-09-12 EP EP24185102.1A patent/EP4434583B1/en active Active
- 2019-09-12 EP EP19778721.1A patent/EP3849970B1/en active Active
- 2019-09-12 ES ES19778721T patent/ES2993173T3/es active Active
-
2021
- 2021-03-10 CL CL2021000596A patent/CL2021000596A1/es unknown
- 2021-03-12 CO CONC2021/0003295A patent/CO2021003295A2/es unknown
- 2021-06-03 US US17/338,182 patent/US11680046B2/en active Active
-
2023
- 2023-05-05 US US18/143,765 patent/US12410133B2/en active Active
-
2025
- 2025-08-06 US US19/292,473 patent/US20260062384A1/en active Pending
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