EA202090930A1 - Соединения, пригодные для ингибирования cdk7 - Google Patents

Соединения, пригодные для ингибирования cdk7

Info

Publication number
EA202090930A1
EA202090930A1 EA202090930A EA202090930A EA202090930A1 EA 202090930 A1 EA202090930 A1 EA 202090930A1 EA 202090930 A EA202090930 A EA 202090930A EA 202090930 A EA202090930 A EA 202090930A EA 202090930 A1 EA202090930 A1 EA 202090930A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds suitable
cdk7 inhibition
cdk7
inhibition
pharmaceutically acceptable
Prior art date
Application number
EA202090930A
Other languages
English (en)
Other versions
EA039950B1 (ru
Inventor
Дэвид Эндрю Коутс
Карлос Монтеро
Бхарвин Кумар Рамешандра Пател
Дэвид Майкл Ремик
Випин Ядав
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Priority claimed from PCT/US2018/060025 external-priority patent/WO2019099298A1/en
Publication of EA202090930A1 publication Critical patent/EA202090930A1/ru
Publication of EA039950B1 publication Critical patent/EA039950B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В данном изобретении представлены новые ингибиторы CDK7 и их фармацевтические композицииили их фармацевтически приемлемая соль.
EA202090930A 2018-07-20 2018-11-09 Соединения, пригодные для ингибирования cdk7 EA039950B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382546 2018-07-20
PCT/US2018/060025 WO2019099298A1 (en) 2017-11-16 2018-11-09 Compounds useful for inhibiting cdk7

Publications (2)

Publication Number Publication Date
EA202090930A1 true EA202090930A1 (ru) 2020-08-06
EA039950B1 EA039950B1 (ru) 2022-03-31

Family

ID=63103887

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090930A EA039950B1 (ru) 2018-07-20 2018-11-09 Соединения, пригодные для ингибирования cdk7

Country Status (2)

Country Link
EA (1) EA039950B1 (ru)
PT (1) PT3710446T (ru)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3129371B1 (en) * 2014-04-05 2020-07-29 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
CA2978170C (en) * 2015-03-09 2024-02-27 Aurigene Discovery Technologies Limited Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors

Also Published As

Publication number Publication date
PT3710446T (pt) 2022-09-20
EA039950B1 (ru) 2022-03-31

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