EA201792676A1 - Ингибиторы jak1 - Google Patents

Ингибиторы jak1

Info

Publication number
EA201792676A1
EA201792676A1 EA201792676A EA201792676A EA201792676A1 EA 201792676 A1 EA201792676 A1 EA 201792676A1 EA 201792676 A EA201792676 A EA 201792676A EA 201792676 A EA201792676 A EA 201792676A EA 201792676 A1 EA201792676 A1 EA 201792676A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
jak1
jak1 inhibitors
cancer
pharmaceutically acceptable
Prior art date
Application number
EA201792676A
Other languages
English (en)
Other versions
EA033572B1 (ru
Inventor
Джошуа Райан Клейтон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201792676A1 publication Critical patent/EA201792676A1/ru
Publication of EA033572B1 publication Critical patent/EA033572B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к некоторым бензимидазольным соединениям или их фармацевтически приемлемым солям, которые ингибируют Янус-киназу 1 (JAK1), к фармацевтическим композициям, содержащим указанные соединения, и к способам применения указанных соединений для лечения некоторых типов рака.
EA201792676A 2015-08-04 2016-07-28 Бензимидазольные соединения в качестве ингибиторов jak1 EA033572B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562200684P 2015-08-04 2015-08-04
PCT/US2016/044410 WO2017023672A1 (en) 2015-08-04 2016-07-28 4-(3-pyrazolylamino)-benzimidazole compounds and their use as jak1 inhibitors

Publications (2)

Publication Number Publication Date
EA201792676A1 true EA201792676A1 (ru) 2018-07-31
EA033572B1 EA033572B1 (ru) 2019-11-06

Family

ID=56618268

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792676A EA033572B1 (ru) 2015-08-04 2016-07-28 Бензимидазольные соединения в качестве ингибиторов jak1

Country Status (27)

Country Link
US (1) US9556153B1 (ru)
EP (1) EP3331873B1 (ru)
JP (1) JP6470869B2 (ru)
KR (1) KR102032792B1 (ru)
CN (1) CN108026076B (ru)
AR (1) AR105400A1 (ru)
AU (1) AU2016302748B2 (ru)
BR (1) BR112017028240B1 (ru)
CA (1) CA2990471C (ru)
CY (1) CY1121909T1 (ru)
DK (1) DK3331873T3 (ru)
EA (1) EA033572B1 (ru)
ES (1) ES2743499T3 (ru)
HR (1) HRP20191227T1 (ru)
HU (1) HUE047037T2 (ru)
LT (1) LT3331873T (ru)
MA (1) MA44383B1 (ru)
MD (1) MD3331873T2 (ru)
ME (1) ME03451B (ru)
MX (1) MX2018001306A (ru)
NZ (1) NZ738247A (ru)
PL (1) PL3331873T3 (ru)
PT (1) PT3331873T (ru)
RS (1) RS58974B1 (ru)
SI (1) SI3331873T1 (ru)
TW (1) TW201718555A (ru)
WO (1) WO2017023672A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013486A1 (en) * 2016-07-14 2018-01-18 Eli Lilly And Company Pyrazolylaminobenzimidazole derivatives as jak inhibitors
GB201717260D0 (en) * 2017-10-20 2017-12-06 Galapagos Nv Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013025628A1 (en) * 2011-08-15 2013-02-21 Ligand Pharmaceuticals Incorporated Janus kinase inhibitor compounds and methods
KR20150008907A (ko) * 2012-06-14 2015-01-23 일라이 릴리 앤드 캄파니 Jak1 및 jak2의 억제제
GB201401086D0 (en) * 2014-01-23 2014-03-12 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Also Published As

Publication number Publication date
BR112017028240A2 (pt) 2018-09-04
HRP20191227T1 (hr) 2019-10-18
JP2018524384A (ja) 2018-08-30
US9556153B1 (en) 2017-01-31
NZ738247A (en) 2019-06-28
US20170037034A1 (en) 2017-02-09
CN108026076B (zh) 2020-07-10
LT3331873T (lt) 2019-08-26
CY1121909T1 (el) 2020-10-14
RS58974B1 (sr) 2019-08-30
MX2018001306A (es) 2018-05-17
CA2990471A1 (en) 2017-02-09
CN108026076A (zh) 2018-05-11
CA2990471C (en) 2020-01-07
SI3331873T1 (sl) 2019-08-30
AU2016302748B2 (en) 2019-02-28
DK3331873T3 (da) 2019-08-12
MD3331873T2 (ro) 2019-11-30
AR105400A1 (es) 2017-09-27
ME03451B (me) 2020-01-20
ES2743499T3 (es) 2020-02-19
MA44383B1 (fr) 2019-08-30
MA44383A (fr) 2019-01-23
JP6470869B2 (ja) 2019-02-13
WO2017023672A1 (en) 2017-02-09
PL3331873T3 (pl) 2019-11-29
HUE047037T2 (hu) 2020-04-28
EP3331873B1 (en) 2019-06-26
BR112017028240B1 (pt) 2023-04-11
KR102032792B1 (ko) 2019-10-16
PT3331873T (pt) 2019-09-12
TW201718555A (zh) 2017-06-01
KR20180022966A (ko) 2018-03-06
EA033572B1 (ru) 2019-11-06
AU2016302748A1 (en) 2018-01-04
EP3331873A1 (en) 2018-06-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM