KR102844245B1 - 결정질 (r)-5-카바모일피리딘-3-일-2-메틸-4-(3-(트리플루오로메톡시)벤질)피페라진-1-카르복실레이트, 이의 조성물 및 사용 방법 - Google Patents

결정질 (r)-5-카바모일피리딘-3-일-2-메틸-4-(3-(트리플루오로메톡시)벤질)피페라진-1-카르복실레이트, 이의 조성물 및 사용 방법

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Publication number
KR102844245B1
KR102844245B1 KR1020217010747A KR20217010747A KR102844245B1 KR 102844245 B1 KR102844245 B1 KR 102844245B1 KR 1020217010747 A KR1020217010747 A KR 1020217010747A KR 20217010747 A KR20217010747 A KR 20217010747A KR 102844245 B1 KR102844245 B1 KR 102844245B1
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South Korea
Prior art keywords
carbamoylpyridin
trifluoromethoxy
methyl
piperazine
benzyl
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KR1020217010747A
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Korean (ko)
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KR20210057789A (ko
Inventor
리안펭 황
낸시 트수
니콜 수잔 화이트
준 슈
쿤 장
Original Assignee
셀진 코포레이션
룬드벡 라 졸라 리서치 센터 인코포레이티드
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Publication of KR20210057789A publication Critical patent/KR20210057789A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020217010747A 2018-09-13 2019-09-12 결정질 (r)-5-카바모일피리딘-3-일-2-메틸-4-(3-(트리플루오로메톡시)벤질)피페라진-1-카르복실레이트, 이의 조성물 및 사용 방법 Active KR102844245B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862731014P 2018-09-13 2018-09-13
US62/731,014 2018-09-13
PCT/US2019/050771 WO2020056105A1 (en) 2018-09-13 2019-09-12 Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1-carboxylate, compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
KR20210057789A KR20210057789A (ko) 2021-05-21
KR102844245B1 true KR102844245B1 (ko) 2025-08-11

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KR1020217010747A Active KR102844245B1 (ko) 2018-09-13 2019-09-12 결정질 (r)-5-카바모일피리딘-3-일-2-메틸-4-(3-(트리플루오로메톡시)벤질)피페라진-1-카르복실레이트, 이의 조성물 및 사용 방법

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EP (2) EP4434583B1 (enExample)
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CN (3) CN118561814A (enExample)
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BR (1) BR112021004340A2 (enExample)
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CL (1) CL2021000596A1 (enExample)
CO (1) CO2021003295A2 (enExample)
DK (1) DK3849970T3 (enExample)
EA (1) EA202190511A1 (enExample)
ES (1) ES2993173T3 (enExample)
FI (1) FI3849970T3 (enExample)
HR (1) HRP20241294T1 (enExample)
HU (1) HUE068147T2 (enExample)
IL (1) IL281276B2 (enExample)
LT (1) LT3849970T (enExample)
MA (1) MA53607B1 (enExample)
MX (1) MX2021002923A (enExample)
MY (2) MY210363A (enExample)
PL (1) PL3849970T3 (enExample)
PT (1) PT3849970T (enExample)
RS (1) RS65967B1 (enExample)
SG (1) SG11202102143RA (enExample)
SI (1) SI3849970T1 (enExample)
SM (1) SMT202400369T1 (enExample)
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Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
AU2019337623B2 (en) 2018-09-13 2024-12-05 Celgene Corporation Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1- carboxylate, compositions and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018169880A1 (en) 2017-03-13 2018-09-20 Abide Therapeutics, Inc. Dual magl and faah inhibitors

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
TWI385164B (zh) 2005-02-17 2013-02-11 Astellas Pharma Inc Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (II)
EP3099332A4 (en) * 2014-01-29 2017-06-21 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
AU2019337623B2 (en) 2018-09-13 2024-12-05 Celgene Corporation Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1- carboxylate, compositions and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018169880A1 (en) 2017-03-13 2018-09-20 Abide Therapeutics, Inc. Dual magl and faah inhibitors

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Publication number Publication date
CN113227069A (zh) 2021-08-06
CO2021003295A2 (es) 2021-07-30
CN118561814A (zh) 2024-08-30
US12410133B2 (en) 2025-09-09
MY208901A (en) 2025-06-09
AU2019337623B2 (en) 2024-12-05
BR112021004340A2 (pt) 2021-05-25
US20230382861A1 (en) 2023-11-30
EP3849970B1 (en) 2024-07-03
AU2019337623A1 (en) 2021-05-13
HRP20241294T1 (hr) 2024-12-06
JP7405840B2 (ja) 2023-12-26
MY210363A (en) 2025-09-13
PT3849970T (pt) 2024-09-25
PL3849970T3 (pl) 2025-01-07
EP4434583A2 (en) 2024-09-25
WO2020056105A9 (en) 2020-05-28
HUE068147T2 (hu) 2024-12-28
US11680046B2 (en) 2023-06-20
EP4434583A3 (en) 2024-11-20
JP2022500441A (ja) 2022-01-04
CL2021000596A1 (es) 2021-07-30
IL281276B1 (en) 2024-09-01
US20210363105A1 (en) 2021-11-25
CA3112200A1 (en) 2020-03-19
SG11202102143RA (en) 2021-04-29
EP4434583B1 (en) 2026-04-01
KR20210057789A (ko) 2021-05-21
EA202190511A1 (ru) 2021-07-05
DK3849970T3 (da) 2024-09-30
WO2020056105A1 (en) 2020-03-19
MX2021002923A (es) 2021-09-08
IL281276A (en) 2021-04-29
US11053199B2 (en) 2021-07-06
MA53607B1 (fr) 2025-05-30
EP3849970A1 (en) 2021-07-21
MA53607A (fr) 2021-12-22
FI3849970T3 (fi) 2024-09-20
CN118530218A (zh) 2024-08-23
IL281276B2 (en) 2025-01-01
ES2993173T3 (en) 2024-12-23
SMT202400369T1 (it) 2024-11-15
US20260062384A1 (en) 2026-03-05
RS65967B1 (sr) 2024-10-31
CN113227069B (zh) 2024-11-05
US20200095201A1 (en) 2020-03-26
SI3849970T1 (sl) 2024-11-29
LT3849970T (lt) 2024-10-10

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