EA202190417A1 - Мышечно-специфические комплексы и их применение для лечения болезни помпе - Google Patents

Мышечно-специфические комплексы и их применение для лечения болезни помпе

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Publication number
EA202190417A1
EA202190417A1 EA202190417A EA202190417A EA202190417A1 EA 202190417 A1 EA202190417 A1 EA 202190417A1 EA 202190417 A EA202190417 A EA 202190417A EA 202190417 A EA202190417 A EA 202190417A EA 202190417 A1 EA202190417 A1 EA 202190417A1
Authority
EA
Eurasian Patent Office
Prior art keywords
muscle
disease
pump
treatment
application
Prior art date
Application number
EA202190417A
Other languages
English (en)
Russian (ru)
Inventor
Ромеш Р. Субраманиян
Мохаммед Т. Катанани
Тимоти Уиден
Original Assignee
Дайн Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайн Терапьютикс, Инк. filed Critical Дайн Терапьютикс, Инк.
Publication of EA202190417A1 publication Critical patent/EA202190417A1/ru

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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EA202190417A 2018-08-02 2019-08-02 Мышечно-специфические комплексы и их применение для лечения болезни помпе EA202190417A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862713959P 2018-08-02 2018-08-02
PCT/US2019/044960 WO2020028841A1 (en) 2018-08-02 2019-08-02 Muscle targeting complexes and uses thereof for treating pompe disease

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EA202190417A1 true EA202190417A1 (ru) 2021-06-23

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US (1) US20210317226A1 (enExample)
EP (1) EP3830127A4 (enExample)
JP (2) JP2021533197A (enExample)
KR (1) KR20210054513A (enExample)
CN (2) CN112912399A (enExample)
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EA (1) EA202190417A1 (enExample)
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JP7779653B2 (ja) 2018-02-07 2025-12-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 治療用タンパク質送達のための方法および組成物
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