EA201992613A1 - Фармацевтическая композиция, содержащая конструкции на основе биспецифического антитела, обеспечивающая улучшенное хранение и введение - Google Patents
Фармацевтическая композиция, содержащая конструкции на основе биспецифического антитела, обеспечивающая улучшенное хранение и введениеInfo
- Publication number
- EA201992613A1 EA201992613A1 EA201992613A EA201992613A EA201992613A1 EA 201992613 A1 EA201992613 A1 EA 201992613A1 EA 201992613 A EA201992613 A EA 201992613A EA 201992613 A EA201992613 A EA 201992613A EA 201992613 A1 EA201992613 A1 EA 201992613A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- introduction
- basis
- composition containing
- specific antibody
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
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- A—HUMAN NECESSITIES
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Abstract
В настоящем изобретении предусматривается фармацевтическая композиция, улучшенная в отношении хранения и введения, содержащая (a) конструкцию на основе биспецифического антитела, содержащую первый домен, связывающийся с поверхностным антигеном клетки-мишени, и второй домен, связывающийся со вторым антигеном, где конструкция на основе биспецифического антитела присутствует в концентрации в диапазоне от приблизительно 0,5 мкг/мл до 20 мг/мл, (b) консервант в концентрации, эффективной для подавления роста микроорганизмов, и (c) разбавитель, где конструкция на основе биспецифического антитела является стабильной и извлекаемой.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201762502578P | 2017-05-05 | 2017-05-05 | |
PCT/US2018/031347 WO2018204907A1 (en) | 2017-05-05 | 2018-05-07 | Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration |
Publications (1)
Publication Number | Publication Date |
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EA201992613A1 true EA201992613A1 (ru) | 2020-04-15 |
Family
ID=62555170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA201992613A EA201992613A1 (ru) | 2017-05-05 | 2018-05-07 | Фармацевтическая композиция, содержащая конструкции на основе биспецифического антитела, обеспечивающая улучшенное хранение и введение |
Country Status (17)
Country | Link |
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US (1) | US11918650B2 (ru) |
EP (1) | EP3618864A1 (ru) |
JP (1) | JP7325936B2 (ru) |
KR (1) | KR20190141243A (ru) |
CN (1) | CN110913904A (ru) |
AR (1) | AR111773A1 (ru) |
AU (1) | AU2018261951A1 (ru) |
BR (1) | BR112019022751A2 (ru) |
CA (1) | CA3060856A1 (ru) |
CL (1) | CL2019003166A1 (ru) |
EA (1) | EA201992613A1 (ru) |
MA (1) | MA48763A (ru) |
MX (1) | MX2019013142A (ru) |
SG (1) | SG11201909547TA (ru) |
TW (1) | TW201902510A (ru) |
UY (1) | UY37726A (ru) |
WO (1) | WO2018204907A1 (ru) |
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TWI796283B (zh) * | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
RS62841B1 (sr) | 2016-02-03 | 2022-02-28 | Amgen Res Munich Gmbh | Bcma i cd3 konstrukti antitela koji angažuju bispecifične t ćelije |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
JP7314146B2 (ja) * | 2017-12-28 | 2023-07-25 | 中外製薬株式会社 | 細胞傷害誘導治療剤 |
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AU2019351715A1 (en) * | 2018-10-01 | 2021-04-22 | Amgen Inc. | Methods for reducing aggregation of bispecific antibodies |
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MX2022014163A (es) * | 2020-05-11 | 2023-02-22 | Alkermes Pharma Ireland Ltd | Composiciones de polipeptido de fusion il-2 y metodos para fabricarlas y usarlas. |
CN111529721B (zh) * | 2020-05-22 | 2021-08-31 | 四川大学 | 一种自聚型纳米诊疗系统及其制备方法和应用 |
JP2023528305A (ja) * | 2020-05-29 | 2023-07-04 | アムジエン・インコーポレーテツド | 抗体製剤及びその使用 |
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WO2021250275A1 (en) | 2020-06-12 | 2021-12-16 | Ichnos Sciences SA | Antibody formulation diluent |
IL299242A (en) * | 2020-08-24 | 2023-02-01 | Amgen Inc | A pharmaceutical formulation that includes BITE, a bispecific antibody, and methionine |
AU2021340708A1 (en) | 2020-09-11 | 2023-04-13 | Amgen Inc. | Materials and methods to reduce protein aggregation |
WO2022094148A1 (en) * | 2020-10-30 | 2022-05-05 | Encodia, Inc. | Conjugation reagents and methods using 1,2-cyclohexanediones |
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CN112244025A (zh) * | 2020-11-27 | 2021-01-22 | 上海创宏生物科技有限公司 | 大分子蛋白和/或核酸用无菌处理剂及其制备方法和应用 |
AU2022304662A1 (en) * | 2021-06-30 | 2023-11-23 | Amgen Inc. | Method of reconstituting lyophilized formulation |
TW202340240A (zh) * | 2021-11-17 | 2023-10-16 | 大陸商江蘇先聲藥業有限公司 | 多特異性抗體及其藥物用途 |
CN114748618A (zh) * | 2022-04-02 | 2022-07-15 | 重庆智翔金泰生物制药股份有限公司 | 包含针对狂犬病病毒g蛋白的双特异性抗体的药物制剂及其制备方法 |
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- 2018-05-07 KR KR1020197035356A patent/KR20190141243A/ko not_active Application Discontinuation
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- 2018-05-07 EA EA201992613A patent/EA201992613A1/ru unknown
- 2018-05-07 US US15/972,489 patent/US11918650B2/en active Active
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US11918650B2 (en) | 2024-03-05 |
AU2018261951A1 (en) | 2019-10-31 |
KR20190141243A (ko) | 2019-12-23 |
MA48763A (fr) | 2020-04-08 |
JP7325936B2 (ja) | 2023-08-15 |
AR111773A1 (es) | 2019-08-21 |
CL2019003166A1 (es) | 2020-02-28 |
MX2019013142A (es) | 2019-12-16 |
BR112019022751A2 (pt) | 2020-05-19 |
UY37726A (es) | 2018-11-30 |
US20190151448A1 (en) | 2019-05-23 |
SG11201909547TA (en) | 2019-11-28 |
CN110913904A (zh) | 2020-03-24 |
CA3060856A1 (en) | 2018-11-08 |
TW201902510A (zh) | 2019-01-16 |
WO2018204907A1 (en) | 2018-11-08 |
EP3618864A1 (en) | 2020-03-11 |
JP2018188437A (ja) | 2018-11-29 |
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