EA202091217A1 - Конъюгат аналога тубулизина с разветвленными линкерами - Google Patents
Конъюгат аналога тубулизина с разветвленными линкерамиInfo
- Publication number
- EA202091217A1 EA202091217A1 EA202091217A EA202091217A EA202091217A1 EA 202091217 A1 EA202091217 A1 EA 202091217A1 EA 202091217 A EA202091217 A EA 202091217A EA 202091217 A EA202091217 A EA 202091217A EA 202091217 A1 EA202091217 A1 EA 202091217A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tubulisin
- branched
- conjugate
- analogue conjugate
- branched linkers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Настоящее изобретение относится к конъюгации соединения аналога тубулизина со связывающейся с клеткой молекулой с разветвленными линкерами/линкерами боковой цепи для обеспечения лучшей доставки соединения конъюгата и точного целевого лечения аномальных клеток. Оно также относится к способу конъюгации молекулы аналога тубулизина и связывающегося с клеткой лиганда с помощью разветвленных связей, а также к способу применения конъюгата в целевом лечении онкологического, инфекционного и аутоиммунного заболевания.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2017/120454 WO2019127607A1 (en) | 2017-12-31 | 2017-12-31 | A conjugate of a tubulysin analog with branched linkers |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202091217A1 true EA202091217A1 (ru) | 2020-09-18 |
Family
ID=67064953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091217A EA202091217A1 (ru) | 2017-12-31 | 2017-12-31 | Конъюгат аналога тубулизина с разветвленными линкерами |
Country Status (17)
Country | Link |
---|---|
US (3) | US20230149502A1 (ru) |
EP (1) | EP3621652A4 (ru) |
JP (2) | JP7262817B2 (ru) |
KR (2) | KR102603344B1 (ru) |
CN (1) | CN111093707A (ru) |
AU (2) | AU2017445144A1 (ru) |
BR (1) | BR112020010405A2 (ru) |
CA (1) | CA3085634C (ru) |
CL (1) | CL2020001600A1 (ru) |
EA (1) | EA202091217A1 (ru) |
IL (1) | IL275274A (ru) |
MX (1) | MX2020006192A (ru) |
NZ (1) | NZ764814A (ru) |
PH (1) | PH12020550657A1 (ru) |
SG (1) | SG11202004801WA (ru) |
WO (1) | WO2019127607A1 (ru) |
ZA (1) | ZA202003211B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2872157T3 (pl) | 2012-07-12 | 2020-07-13 | Hangzhou Dac Biotech Co., Ltd | Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi |
US11873281B2 (en) | 2012-07-12 | 2024-01-16 | Hangzhou Dac Biotech Co., Ltd. | Conjugates of cell binding molecules with cytotoxic agents |
CN114040779A (zh) * | 2019-06-24 | 2022-02-11 | 杭州多禧生物科技有限公司 | 含支链连接子的细胞结合分子与细胞毒性剂的偶联物 |
US20220249594A1 (en) * | 2019-06-24 | 2022-08-11 | Hangzhou Dac Biotech Co., Ltd | A formulation of a conjugate of a tubulysin analog to a cell-binding molecule |
EP3991752A4 (en) * | 2019-06-29 | 2023-03-29 | Hangzhou Dac Biotech Co., Ltd | CELL BINDING MOLECULE-TUBULYSIN DERIVATIVE CONJUGATE AND METHOD OF PREPARATION THEREOF |
US11596693B2 (en) | 2019-08-07 | 2023-03-07 | Mabplex International Co., Ltd | Antibody-drug conjugates and uses thereof |
CA3108168A1 (en) * | 2020-02-05 | 2021-08-05 | Yue Zhang | Conjugates of cell-binding molecules with cytotoxic agents |
US11045546B1 (en) | 2020-03-30 | 2021-06-29 | Cytodyn Inc. | Methods of treating coronavirus infection |
CN112755173B (zh) * | 2020-12-31 | 2022-01-07 | 深圳市科达顺生物技术有限公司 | 用于治疗三阴性乳腺癌的Ii-Key/HER2杂交多肽药物及其制备方法 |
CN112961060B (zh) * | 2021-02-09 | 2022-03-25 | 武汉大学 | 同位素标记的n,n-二甲基乙二胺及其制备方法和短链脂肪酸的分析方法 |
AU2022259314A1 (en) * | 2021-04-14 | 2023-11-30 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linkers, conjugates and applications thereof |
WO2022078524A2 (en) * | 2021-11-03 | 2022-04-21 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1521769B1 (de) * | 2002-07-09 | 2015-09-09 | Dömling, Alexander | Tubulysinkonjugate |
CN101678124A (zh) * | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
CA2891280C (en) * | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
PT3122757T (pt) | 2014-02-28 | 2023-11-03 | Hangzhou Dac Biotech Co Ltd | Ligantes carregados e as suas utilizações em conjugação |
KR20160142392A (ko) * | 2014-04-11 | 2016-12-12 | 메디뮨 엘엘씨 | 튜부리신 유도체 |
CN110279872A (zh) * | 2014-11-11 | 2019-09-27 | 杭州多禧生物科技有限公司 | 细胞毒素分子同细胞结合受体分子的共轭体 |
WO2015151078A2 (en) | 2015-06-15 | 2015-10-08 | Suzhou M-Conj Biotech Co., Ltd | Hydrophilic linkers for conjugation |
CA2991975C (en) * | 2015-08-10 | 2021-04-06 | Suzhou M-Conj Biotech Co., Ltd. | Novel linkers and their uses in specific conjugation of drugs to a biological molecule |
AU2016202632B2 (en) * | 2016-02-04 | 2021-09-09 | Hangzhou Dac Biotech Co, Ltd | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof |
BR112018071465A2 (pt) * | 2016-04-20 | 2019-02-05 | Hangzhou Dac Biotech Co Ltd | derivados de toxinas de amanita e sua conjugação a uma molécula de ligação celular |
JP7138350B2 (ja) * | 2016-11-14 | 2022-09-16 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ. | 共役連結体、該連結体を含有する細胞結合分子-薬物共役体、並びに該共役体及び連結体の使用及び製造方法 |
EA201992081A1 (ru) * | 2017-04-06 | 2020-01-21 | Ханчжоу Дэк Биотек Ко., Лтд | Конъюгирование цитотоксических лекарственных средств посредством бис-связывания |
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2017
- 2017-12-31 EP EP17936036.7A patent/EP3621652A4/en active Pending
- 2017-12-31 EA EA202091217A patent/EA202091217A1/ru unknown
- 2017-12-31 SG SG11202004801WA patent/SG11202004801WA/en unknown
- 2017-12-31 KR KR1020207019406A patent/KR102603344B1/ko active IP Right Grant
- 2017-12-31 WO PCT/CN2017/120454 patent/WO2019127607A1/en unknown
- 2017-12-31 MX MX2020006192A patent/MX2020006192A/es unknown
- 2017-12-31 JP JP2020535958A patent/JP7262817B2/ja active Active
- 2017-12-31 CA CA3085634A patent/CA3085634C/en active Active
- 2017-12-31 AU AU2017445144A patent/AU2017445144A1/en not_active Abandoned
- 2017-12-31 KR KR1020237017364A patent/KR102641565B1/ko active IP Right Grant
- 2017-12-31 NZ NZ764814A patent/NZ764814A/en unknown
- 2017-12-31 BR BR112020010405-1A patent/BR112020010405A2/pt unknown
- 2017-12-31 CN CN201780094901.3A patent/CN111093707A/zh active Pending
-
2020
- 2020-05-18 PH PH12020550657A patent/PH12020550657A1/en unknown
- 2020-05-28 ZA ZA2020/03211A patent/ZA202003211B/en unknown
- 2020-06-10 IL IL275274A patent/IL275274A/en unknown
- 2020-06-15 CL CL2020001600A patent/CL2020001600A1/es unknown
-
2022
- 2022-07-15 AU AU2022205269A patent/AU2022205269A1/en active Pending
-
2023
- 2023-01-19 US US18/156,793 patent/US20230149502A1/en active Pending
- 2023-01-19 US US18/156,709 patent/US20230165930A1/en active Pending
- 2023-01-19 US US18/156,748 patent/US20230165931A1/en active Pending
- 2023-04-05 JP JP2023061065A patent/JP2023093531A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR102641565B1 (ko) | 2024-02-27 |
KR102603344B1 (ko) | 2023-11-16 |
AU2017445144A1 (en) | 2020-06-18 |
JP7262817B2 (ja) | 2023-04-24 |
EP3621652A4 (en) | 2021-01-13 |
EP3621652A1 (en) | 2020-03-18 |
US20200276261A1 (en) | 2020-09-03 |
IL275274A (en) | 2020-07-30 |
CL2020001600A1 (es) | 2021-03-19 |
ZA202003211B (en) | 2024-04-24 |
NZ764814A (en) | 2024-02-23 |
BR112020010405A2 (pt) | 2020-11-24 |
KR20230075530A (ko) | 2023-05-31 |
US20230165930A1 (en) | 2023-06-01 |
MX2020006192A (es) | 2020-08-20 |
CA3085634A1 (en) | 2019-07-04 |
US20230165931A1 (en) | 2023-06-01 |
JP2023093531A (ja) | 2023-07-04 |
CA3085634C (en) | 2023-11-14 |
JP2021507928A (ja) | 2021-02-25 |
WO2019127607A1 (en) | 2019-07-04 |
AU2022205269A1 (en) | 2022-08-11 |
PH12020550657A1 (en) | 2021-04-19 |
US20230149502A1 (en) | 2023-05-18 |
SG11202004801WA (en) | 2020-06-29 |
KR20200097295A (ko) | 2020-08-18 |
CN111093707A (zh) | 2020-05-01 |
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