EA202192137A1 - Конъюгат аматоксинового аналога с разветвленными линкерами - Google Patents

Конъюгат аматоксинового аналога с разветвленными линкерами

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Publication number
EA202192137A1
EA202192137A1 EA202192137A EA202192137A EA202192137A1 EA 202192137 A1 EA202192137 A1 EA 202192137A1 EA 202192137 A EA202192137 A EA 202192137A EA 202192137 A EA202192137 A EA 202192137A EA 202192137 A1 EA202192137 A1 EA 202192137A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amatoxy
branched linkers
analogue conjugate
branched
conjugate
Prior art date
Application number
EA202192137A
Other languages
English (en)
Inventor
Роберт Юнсинь Чжао
Цинлян Ян
Цзюнь Лей
Юаньюань Хуан
Линьяо Чжао
Ханбо Е
Шунь Гай
Минцзюнь Цао
Цяньцянь Тун
Лу Бай
Чжисян Го
Ченюй Ян
Сяомай Чжоу
Хуншэн Се
Ифан Сюй
Хуэйхуэй Го
Цзюньсян Цзя
Цзюнь Чжэнь
Чэн Линь
Сяотао Чжо
Вэньцзюнь Ли
Юн Ду
Сянфэй Кун
Биньбинь Чэнь
Яньлэй Ян
Яньхун Тун
Сяосяо Чэнь
Яньхуа Ли
Сючжэн Чжан
Цзюань Лай
Original Assignee
Ханчжоу Дэк Биотек Ко., Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ханчжоу Дэк Биотек Ко., Лтд filed Critical Ханчжоу Дэк Биотек Ко., Лтд
Publication of EA202192137A1 publication Critical patent/EA202192137A1/ru

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Abstract

Изобретение относится к конъюгации соединения аналога аматоксина со связывающейся с клеткой молекулой с разветвленными линкерами. Изобретение также относится к способу конъюгирования молекулы аналога аматоксина с клеточно-связывающим лигандом с разветвленной связью, а также к способам использования конъюгата для направленной профилактики или лечения рака, инфекций и иммунологических нарушений.
EA202192137A 2019-01-31 2019-01-31 Конъюгат аматоксинового аналога с разветвленными линкерами EA202192137A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/074176 WO2020155017A1 (en) 2019-01-31 2019-01-31 A conjugate of an amanita toxin with branched linkers

Publications (1)

Publication Number Publication Date
EA202192137A1 true EA202192137A1 (ru) 2021-10-25

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EA202192137A EA202192137A1 (ru) 2019-01-31 2019-01-31 Конъюгат аматоксинового аналога с разветвленными линкерами

Country Status (14)

Country Link
US (1) US20230057350A1 (ru)
EP (1) EP3917576A4 (ru)
JP (1) JP2022523103A (ru)
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