EA202090571A1 - Конъюгаты производных glp-2 пролонгированного действия - Google Patents
Конъюгаты производных glp-2 пролонгированного действияInfo
- Publication number
- EA202090571A1 EA202090571A1 EA202090571A EA202090571A EA202090571A1 EA 202090571 A1 EA202090571 A1 EA 202090571A1 EA 202090571 A EA202090571 A EA 202090571A EA 202090571 A EA202090571 A EA 202090571A EA 202090571 A1 EA202090571 A1 EA 202090571A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- glp
- conjugates
- derivatives
- extended action
- extended
- Prior art date
Links
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 title abstract 5
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 abstract 2
- 102100040918 Pro-glucagon Human genes 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170126577 | 2017-09-28 | ||
| PCT/KR2018/011586 WO2019066586A1 (ko) | 2017-09-28 | 2018-09-28 | 글루카곤 유사 펩타이드-2(glp-2) 유도체의 지속형 결합체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202090571A1 true EA202090571A1 (ru) | 2020-07-30 |
Family
ID=65902619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090571A EA202090571A1 (ru) | 2017-09-28 | 2018-09-28 | Конъюгаты производных glp-2 пролонгированного действия |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11530249B2 (enExample) |
| EP (1) | EP3689898B1 (enExample) |
| JP (2) | JP7751381B2 (enExample) |
| KR (2) | KR102681143B1 (enExample) |
| CN (1) | CN111433221B (enExample) |
| AR (1) | AR113258A1 (enExample) |
| AU (1) | AU2018339210B2 (enExample) |
| BR (1) | BR112020006189A2 (enExample) |
| CA (1) | CA3084326A1 (enExample) |
| EA (1) | EA202090571A1 (enExample) |
| IL (1) | IL273528B2 (enExample) |
| MX (1) | MX2020004453A (enExample) |
| PH (1) | PH12020550105A1 (enExample) |
| SA (1) | SA520411644B1 (enExample) |
| SG (1) | SG11202002563WA (enExample) |
| TW (2) | TWI795443B (enExample) |
| WO (1) | WO2019066586A1 (enExample) |
| ZA (1) | ZA202001888B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202111311WA (en) | 2019-06-14 | 2021-12-30 | Zealand Pharma As | Pharmaceutical parenteral composition of dual glp1/2 agonist |
| JP7846622B2 (ja) * | 2019-12-24 | 2026-04-15 | ハンミ ファーマシューティカル カンパニー リミテッド | Ｇｌｐ－２又はその結合体を含む、代謝性骨疾患の予防又は治療用薬学的組成物 |
| EP4126004A1 (en) | 2020-03-30 | 2023-02-08 | Zealand Pharma A/S | Agonist combination |
| WO2021201654A1 (ko) | 2020-04-03 | 2021-10-07 | 한미약품 주식회사 | Glp-2 유도체 또는 이의 지속형 결합체를 포함하는 방사선요법, 화학요법, 또는 이들의 조합으로 유발된 점막염의 예방 또는 치료용 약학적 조성물 |
| MX2022014671A (es) * | 2020-05-22 | 2023-02-13 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de conjugado de glp-2 de accion prolongada. |
| BR112022025141A2 (pt) | 2020-06-09 | 2023-04-25 | Vectivbio Ag | Fabricação, formulação e dosagem de apraglutida |
| KR20220092446A (ko) * | 2020-12-24 | 2022-07-01 | 한미약품 주식회사 | 단장증후군의 예방 또는 치료를 위한 인슐린 분비 펩타이드 및 glp-2의 병용 요법 |
| JP2025513345A (ja) * | 2022-04-18 | 2025-04-24 | ハンミ ファーマシューティカル カンパニー リミテッド | 腸疾患の予防又は治療のためのＧＬＰ－２と、インスリン分泌ペプチド、ＴＮＦα抑制剤、又はその両方の併用療法 |
| CN120435309A (zh) | 2022-12-23 | 2025-08-05 | 韩美药品株式会社 | 含有glp-2衍生物或其长效缀合物的用于预防或治疗移植物抗宿主病的药物组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| DK1360202T3 (da) * | 2001-02-16 | 2008-09-22 | Conjuchem Biotechnologies Inc | Langvarigt glucagon-lignende peptid 2 (GLP-2) til behandling af gastrointestinale sygdomme og lidelser |
| US20090238838A1 (en) * | 2003-11-13 | 2009-09-24 | Hanmi Pharm. Ind. Co. Ltd. | Insulinotropic peptide conjugate using an immunoglobulin fc |
| HRP20060362A2 (en) * | 2004-04-23 | 2007-03-31 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| UA95235C2 (en) * | 2005-05-04 | 2011-07-25 | Зииланд Фарма А/С | Glucagon-like-peptide-2 (glp-2) analogues |
| JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| US20110171164A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of glp-2-like peptides |
| KR101746686B1 (ko) * | 2010-10-26 | 2017-06-15 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 글루카곤 유사 펩타이드―２（ｇｌｐ―２）약물 결합체 |
| JP6206972B2 (ja) * | 2011-09-12 | 2017-10-04 | アムニクス オペレーティング インコーポレイテッド | グルカゴン様ペプチド−２組成物およびその作製法および使用法 |
| KR101895047B1 (ko) * | 2011-12-30 | 2018-09-06 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 위치 특이적 글루카곤 유사 펩타이드-2 약물 결합체 |
-
2018
- 2018-09-28 EA EA202090571A patent/EA202090571A1/ru unknown
- 2018-09-28 SG SG11202002563WA patent/SG11202002563WA/en unknown
- 2018-09-28 AR ARP180102806A patent/AR113258A1/es unknown
- 2018-09-28 BR BR112020006189-1A patent/BR112020006189A2/pt unknown
- 2018-09-28 IL IL273528A patent/IL273528B2/en unknown
- 2018-09-28 EP EP18860379.9A patent/EP3689898B1/en active Active
- 2018-09-28 CN CN201880074180.4A patent/CN111433221B/zh active Active
- 2018-09-28 TW TW107134398A patent/TWI795443B/zh active
- 2018-09-28 MX MX2020004453A patent/MX2020004453A/es unknown
- 2018-09-28 KR KR1020180116327A patent/KR102681143B1/ko active Active
- 2018-09-28 WO PCT/KR2018/011586 patent/WO2019066586A1/ko not_active Ceased
- 2018-09-28 TW TW110126453A patent/TWI794897B/zh active
- 2018-09-28 CA CA3084326A patent/CA3084326A1/en active Pending
- 2018-09-28 JP JP2020517828A patent/JP7751381B2/ja active Active
- 2018-09-28 AU AU2018339210A patent/AU2018339210B2/en active Active
-
2020
- 2020-03-19 PH PH12020550105A patent/PH12020550105A1/en unknown
- 2020-03-24 ZA ZA2020/01888A patent/ZA202001888B/en unknown
- 2020-03-27 US US16/832,634 patent/US11530249B2/en active Active
- 2020-03-28 SA SA520411644A patent/SA520411644B1/ar unknown
-
2022
- 2022-04-14 US US17/721,048 patent/US20220251164A1/en active Pending
- 2022-11-02 US US17/979,531 patent/US20230090790A1/en active Pending
-
2023
- 2023-07-06 JP JP2023111438A patent/JP2023138505A/ja active Pending
-
2024
- 2024-01-22 KR KR1020240009740A patent/KR102681144B1/ko active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA202090571A1 (ru) | Конъюгаты производных glp-2 пролонгированного действия | |
| CL2023000198A1 (es) | Derivado de glucagón y una composición que comprende un conjugado de acción prolongada del mismo | |
| MX2024002632A (es) | Enlazadores que contienen peptido para conjugados anticuerpo-farmaco. | |
| CY1121949T1 (el) | Φαρμακοτεχνικες μορφες συζευγματος anti-egfr αντισωματος-φαρμακου | |
| CY1121783T1 (el) | Συζευγμα αντισωματος-igf-1r-φαρμακου και η χρηση αυτου για την αγωγη του καρκινου | |
| MX2021008334A (es) | Ligadores que modulan la estabilidad para usar con conjugados anticuerpo-farmaco. | |
| PH12018500693A1 (en) | Pyrrolobenzodiazepine antibody drug conjugates and methods of use | |
| MX2022014125A (es) | Anticuerpos y conjugados de los mismos. | |
| CR20160596A (es) | Ácidos grasos novedosos y su uso en la conjugación con biomoléculas | |
| MX2021010550A (es) | Conjugados de anticuerpo-farmaco hidrofilicos. | |
| EA201690744A1 (ru) | Конъюгаты белок-полимер-лекарственное средство | |
| BR112016024525A2 (pt) | novos anticorpos anti-rnf43 e métodos de uso | |
| CL2018003754A1 (es) | Derivado de glucagon, conjugado del mismo, composición que comprende el mismo y uso terapéutico del mismo. | |
| TN2017000246A1 (en) | Anti-c10orf54 antibodies and uses thereof | |
| MX389728B (es) | Conjugados de farmacos proteinas de union que comprenden derivados de antraciclina. | |
| CY1122822T1 (el) | Σακχαριτες παραγωγοποιημενοι με κυκλοαλκινιο | |
| ZA201803476B (en) | Anti-cd22 antibody-maytansine conjugates and methods of use thereof | |
| ECSP18010616A (es) | Inmunoconjugados de il22 | |
| MX2018007818A (es) | Anticuerpos dirigidos contra upk1b novedosos y metodos para su uso. | |
| EP4400507A3 (en) | Multidimensional chromatography method for analysis of antibody-drug conjugates | |
| CY1124480T1 (el) | Βελτιωμενη διεργασια για τη συνθεση του συνδετη-φαρμακου vc-seco | |
| CL2023000971A1 (es) | Esteroides y conjugados de proteínas de los mismos. | |
| EA201892068A1 (ru) | Конъюгаты napi2b-нацеленное антитело-лекарственное средство и способы их применения | |
| EA201990011A1 (ru) | Производное глюкагона, конъюгат на его основе, содержащая их композиция и их терапевтическое применение |