CY1122822T1 - Σακχαριτες παραγωγοποιημενοι με κυκλοαλκινιο - Google Patents

Σακχαριτες παραγωγοποιημενοι με κυκλοαλκινιο

Info

Publication number
CY1122822T1
CY1122822T1 CY20201100223T CY201100223T CY1122822T1 CY 1122822 T1 CY1122822 T1 CY 1122822T1 CY 20201100223 T CY20201100223 T CY 20201100223T CY 201100223 T CY201100223 T CY 201100223T CY 1122822 T1 CY1122822 T1 CY 1122822T1
Authority
CY
Cyprus
Prior art keywords
cycloalkynium
sugars
derivative
derivative sugars
conjugates
Prior art date
Application number
CY20201100223T
Other languages
English (en)
Inventor
Roberto ADAMO
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of CY1122822T1 publication Critical patent/CY1122822T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof

Abstract

Η εφεύρεση παρέχει νέα σακχαριτικά παράγωγα, συζεύγματα, και μεθόδους παρασκευής των παραγώγων και συζευγμάτων.
CY20201100223T 2013-01-15 2020-03-13 Σακχαριτες παραγωγοποιημενοι με κυκλοαλκινιο CY1122822T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1300707.5A GB201300707D0 (en) 2013-01-15 2013-01-15 Compounds and processes
PCT/EP2014/050483 WO2014111344A1 (en) 2013-01-15 2014-01-13 Cycloalkyne derivatized saccharides

Publications (1)

Publication Number Publication Date
CY1122822T1 true CY1122822T1 (el) 2021-05-05

Family

ID=47758014

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100223T CY1122822T1 (el) 2013-01-15 2020-03-13 Σακχαριτες παραγωγοποιημενοι με κυκλοαλκινιο

Country Status (16)

Country Link
US (2) US11135300B2 (el)
EP (1) EP2945641B1 (el)
JP (3) JP6719209B2 (el)
CN (1) CN105377282B (el)
BR (1) BR112015016817B1 (el)
CA (1) CA2897348C (el)
CY (1) CY1122822T1 (el)
DK (1) DK2945641T3 (el)
ES (1) ES2774729T3 (el)
GB (1) GB201300707D0 (el)
HR (1) HRP20200351T1 (el)
LT (1) LT2945641T (el)
PL (1) PL2945641T3 (el)
PT (1) PT2945641T (el)
SI (1) SI2945641T1 (el)
WO (1) WO2014111344A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201300707D0 (en) * 2013-01-15 2013-02-27 Novartis Ag Compounds and processes
WO2017149858A1 (ja) * 2016-03-04 2017-09-08 株式会社ユーグレナ 抗ウイルス剤及び抗ウイルス用食品
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
BR112019013475A2 (pt) 2016-12-30 2020-02-27 Sutrovax, Inc. Conjugados de polipeptídeo-antígeno com aminoácidos não naturais
JP7295571B2 (ja) * 2018-02-05 2023-06-21 国立大学法人 宮崎大学 細胞標識剤及び細胞標識キット
KR20210019441A (ko) 2018-06-14 2021-02-22 모찌다 세이야쿠 가부시끼가이샤 신규 가교 알긴산
WO2020010016A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Self-adjuvanted immunogenic conjugates
PE20240090A1 (es) * 2021-05-28 2024-01-16 Pfizer Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60325565D1 (de) 2002-03-26 2009-02-12 Novartis Vaccines & Diagnostic Modifizierte saccharide mit verbesserter stabilität in wasser
JP2008518953A (ja) * 2004-11-01 2008-06-05 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 連鎖球菌修飾多糖類およびそれらの使用法
GB0502095D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
DK2222341T3 (en) * 2007-11-21 2015-03-09 Univ Georgia AND METHODS alkynes of reacting alkynes of 1,3-dipole FUNCTIONAL COMPOUNDS
ITVI20090234A1 (it) * 2009-09-25 2011-03-26 Termotecniche Fraccaro S R L Off Dispositivo per il riscaldamento di ambienti ad alta efficienza energetica, nonche' sistema riscaldante comprendente tale dispositivo
CA2785410A1 (en) 2009-12-23 2011-06-30 Carlos F. Barbas, Iii Tyrosine bioconjugation through aqueous ene-like reactions
CN103153927B (zh) * 2010-04-27 2017-02-15 西纳福克斯股份有限公司 稠合的环辛炔化合物及其在无金属点击反应中的应用
WO2012017701A1 (ja) * 2010-08-05 2012-02-09 株式会社ミュージックゲート いびき防止マスク
GB201101665D0 (en) 2011-01-31 2011-03-16 Novartis Ag Immunogenic compositions
US9315468B2 (en) 2010-09-27 2016-04-19 University Of Georgia Research Foundation, Inc. Methods including latent 1,3-dipole-functional compounds and materials prepared thereby
US20120208722A1 (en) * 2010-10-19 2012-08-16 Richard Dluhy Surface enhanced raman spectroscopy platforms and methods
CA2843313C (en) * 2011-06-20 2018-02-13 Radiomedix Inc. Compositions, methods of synthesis and use of carbohydrate targeted agents
JP2015500800A (ja) * 2011-12-01 2015-01-08 アンジオケム インコーポレーテッド 標的化イズロン酸−２−スルファターゼ化合物
GB201300707D0 (en) * 2013-01-15 2013-02-27 Novartis Ag Compounds and processes

Also Published As

Publication number Publication date
HRP20200351T1 (hr) 2020-06-12
JP6719209B2 (ja) 2020-07-08
PL2945641T3 (pl) 2020-06-15
JP2016506905A (ja) 2016-03-07
WO2014111344A1 (en) 2014-07-24
EP2945641A1 (en) 2015-11-25
GB201300707D0 (en) 2013-02-27
ES2774729T3 (es) 2020-07-22
JP2019073528A (ja) 2019-05-16
US11135300B2 (en) 2021-10-05
BR112015016817A2 (pt) 2017-07-11
US20210268116A1 (en) 2021-09-02
US20160166704A1 (en) 2016-06-16
CN105377282A (zh) 2016-03-02
CN105377282B (zh) 2020-07-17
BR112015016817B1 (pt) 2020-11-10
PT2945641T (pt) 2020-03-26
JP7036854B2 (ja) 2022-03-15
SI2945641T1 (sl) 2020-03-31
EP2945641B1 (en) 2020-01-01
CA2897348C (en) 2022-09-27
DK2945641T3 (da) 2020-03-09
CA2897348A1 (en) 2014-07-24
JP2020114839A (ja) 2020-07-30
LT2945641T (lt) 2020-02-25
BR112015016817A8 (pt) 2019-10-29

Similar Documents

Publication Publication Date Title
CY1122822T1 (el) Σακχαριτες παραγωγοποιημενοι με κυκλοαλκινιο
CY1124131T1 (el) Συζευγματα αντι-ρτκ7 αντισωματος-φαρμακου
BR112017005122A2 (pt) derivados tetracíclicos ativos em termos pesticidas com substituintes contendo enxofre.
BR112017015514A2 (pt) derivados policíclicos ativos com substituintes contendo enxofre ativos em termos pesticidas
DK3579883T3 (da) Pyrrolobenzodiazepin-antistofkonjugater
BR112017009454A2 (pt) derivados policíclicos ativos com substituintes contendo enxofre ativos em termos pesticidas
BR112015032224A2 (pt) anticorpos anti-fcrh5
BR112017019371A2 (pt) derivados tetracíclicos ativos em termos pesticidas com substituintes contendo enxofre
CR20150482A (es) Anticuerpos e inmunoconjugados anti-b7-h4
BR112017012232A2 (pt) derivados tetracíclicos ativos em termos pesticidas com substituintes contendo enxofre
BR112017019372A2 (pt) derivados tetracíclicos ativos em termos pesticidas com substituintes contendo enxofre
DK3324980T3 (da) Multimålrettede enkeltenhedskonjugater
PE20150892A1 (es) Anticuerpos anti-notch y conjugados de anticuerpo-farmaco
BR112017014061A2 (pt) derivados tetracíclicos ativos em termos pesticidas com substituintes contendo enxofre
TR201811764T4 (tr) Kinaz inhibitörleri olarak aminoheteroaril benzamidleri.
CY1124425T1 (el) Συνθεσεις οι οποιες περιλαμβανουν συζευγματα φαρμακου αντισωματος-δουοκαρμυκινης
BR112017014064A2 (pt) derivados policíclicos ativos com substituintes contendo enxofre ativos em termos pesticidas
EA201791359A1 (ru) Конъюгаты, связывающие белок-лекарственное средство, содержащие производные антрациклина
BR112016012146A8 (pt) derivados de aminopiridina como inibidores de quinase da família tam
UY4167Q (es) Par de auriculares
UY34602A (es) ?Derivados de bencimidazolil- e imidazopiridinil-metilamina?
CY1120759T1 (el) Παρασκευη διγλυκοζιτη (s,s)-σεκοϊσολαρικιρεσινολης και διγλυκοζιτη (r,r)-σεκοϊσολαρικιρεσινολης
BR112015029754A2 (pt) anticorpos anti-teicoico da parede e conjugados
BR112015019647A2 (pt) criação de perfil de caminho com uso de combinação de hardware e software.
BR112017028600A2 (pt) derivados policíclicos ativos com substituintes contendo enxofre ativos em termos pesticidas