CY1124480T1 - Βελτιωμενη διεργασια για τη συνθεση του συνδετη-φαρμακου vc-seco - Google Patents
Βελτιωμενη διεργασια για τη συνθεση του συνδετη-φαρμακου vc-secoInfo
- Publication number
- CY1124480T1 CY1124480T1 CY20211100786T CY211100786T CY1124480T1 CY 1124480 T1 CY1124480 T1 CY 1124480T1 CY 20211100786 T CY20211100786 T CY 20211100786T CY 211100786 T CY211100786 T CY 211100786T CY 1124480 T1 CY1124480 T1 CY 1124480T1
- Authority
- CY
- Cyprus
- Prior art keywords
- seco
- synthesis
- improved process
- drug
- drug binder
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000011230 binding agent Substances 0.000 title 1
- RFQYSAASDBNNDZ-UCGHAGIGSA-N [(1s)-1-(chloromethyl)-3-[6-[(4-hydroxybenzoyl)amino]imidazo[1,2-a]pyridine-2-carbonyl]-9-methyl-1,2-dihydrobenzo[e]indol-5-yl] n-[2-[[4-[[(2s)-5-(carbamoylamino)-2-[[(2s)-2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxycarbonylamino]-3-methylbutanoyl]amino]pe Chemical compound N([C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=O)C(=O)NC=1C=CC(COC(=O)N(C)CCN(CCOCCO)C(=O)OC=2C3=CC=CC(C)=C3C=3[C@H](CCl)CN(C=3C=2)C(=O)C=2N=C3C=CC(NC(=O)C=4C=CC(O)=CC=4)=CN3C=2)=CC=1)C(=O)OCCOCCN1C(=O)C=CC1=O RFQYSAASDBNNDZ-UCGHAGIGSA-N 0.000 abstract 1
- 239000000611 antibody drug conjugate Substances 0.000 abstract 1
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μία βελτιωμένη διεργασία για τη σύνθεση συνδέτη-φαρμάκου vc-seco-DUBA και ενδιαμέσων ενώσεων αυτού, όπως επίσης τη χρήση της εν λόγω βελτιωμένης διεργασίας σε μία διεργασία για την παρασκευή ενός συζεύγματος αντισώματος-φαρμάκου που περιλαμβάνει τον συνδέτη-φάρμακο vc-seco-DUBA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17203457 | 2017-11-24 | ||
PCT/EP2018/082199 WO2019101850A1 (en) | 2017-11-24 | 2018-11-22 | Improved process for the synthesis of linker-drug vc-seco-duba |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124480T1 true CY1124480T1 (el) | 2022-07-22 |
Family
ID=60452506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100786T CY1124480T1 (el) | 2017-11-24 | 2021-09-06 | Βελτιωμενη διεργασια για τη συνθεση του συνδετη-φαρμακου vc-seco |
Country Status (16)
Country | Link |
---|---|
US (1) | US11633492B2 (el) |
EP (1) | EP3713939B1 (el) |
JP (1) | JP7279042B2 (el) |
KR (1) | KR20200091431A (el) |
CN (1) | CN111556870B (el) |
AU (1) | AU2018371966B2 (el) |
CA (1) | CA3083169A1 (el) |
CY (1) | CY1124480T1 (el) |
DK (1) | DK3713939T3 (el) |
ES (1) | ES2889775T3 (el) |
HR (1) | HRP20211435T1 (el) |
HU (1) | HUE055305T2 (el) |
LT (1) | LT3713939T (el) |
PL (1) | PL3713939T3 (el) |
PT (1) | PT3713939T (el) |
WO (1) | WO2019101850A1 (el) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7714016B2 (en) | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
AU2010293028B2 (en) | 2009-09-08 | 2014-12-18 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
KR101901555B1 (ko) * | 2010-04-21 | 2018-09-21 | 신타가 비.브이. | Cc―1065 유사체와 2작용성 링커의 신규한 콘쥬게이트 |
DK3151865T3 (da) * | 2014-05-22 | 2021-10-25 | Byondis Bv | Stedsspecifik konjugation af linker medicin til antistof og resulterende adcs |
EP3152191B1 (en) | 2014-06-05 | 2019-05-15 | Synthon Biopharmaceuticals B.V. | Improved process for making duocarmycin prodrugs |
JP2015199772A (ja) | 2015-06-25 | 2015-11-12 | シグネーチャー セラピューティクス,インク.Signature Therapeutics, Inc. | 酵素切断可能なオピオイドプロドラッグとそのインヒビターとを含んでなる組成物 |
HUE050726T2 (hu) | 2016-02-12 | 2021-01-28 | Byondis Bv | Génsebészeti eljárással bejuttatott ciszteint tartalmazó ellenanyagok szelektív redukálása |
JP7058666B2 (ja) | 2016-11-25 | 2022-04-22 | マブウェル (シャンハイ) バイオサイエンス カンパニー リミテッド | 抗体-薬物複合体化のための二置換マレインアミドリンカーならびにその調製方法および使用 |
-
2018
- 2018-11-22 DK DK18811180.1T patent/DK3713939T3/da active
- 2018-11-22 WO PCT/EP2018/082199 patent/WO2019101850A1/en unknown
- 2018-11-22 CN CN201880075808.2A patent/CN111556870B/zh active Active
- 2018-11-22 HU HUE18811180A patent/HUE055305T2/hu unknown
- 2018-11-22 JP JP2020528269A patent/JP7279042B2/ja active Active
- 2018-11-22 PT PT188111801T patent/PT3713939T/pt unknown
- 2018-11-22 US US16/766,150 patent/US11633492B2/en active Active
- 2018-11-22 HR HRP20211435TT patent/HRP20211435T1/hr unknown
- 2018-11-22 LT LTEPPCT/EP2018/082199T patent/LT3713939T/lt unknown
- 2018-11-22 ES ES18811180T patent/ES2889775T3/es active Active
- 2018-11-22 CA CA3083169A patent/CA3083169A1/en active Pending
- 2018-11-22 AU AU2018371966A patent/AU2018371966B2/en active Active
- 2018-11-22 PL PL18811180T patent/PL3713939T3/pl unknown
- 2018-11-22 KR KR1020207018101A patent/KR20200091431A/ko not_active Application Discontinuation
- 2018-11-22 EP EP18811180.1A patent/EP3713939B1/en active Active
-
2021
- 2021-09-06 CY CY20211100786T patent/CY1124480T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2019101850A1 (en) | 2019-05-31 |
AU2018371966A1 (en) | 2020-06-18 |
DK3713939T3 (da) | 2021-09-13 |
US20200368362A1 (en) | 2020-11-26 |
RU2020120838A3 (el) | 2022-03-03 |
PT3713939T (pt) | 2021-09-16 |
CA3083169A1 (en) | 2019-05-31 |
JP7279042B2 (ja) | 2023-05-22 |
CN111556870B (zh) | 2023-09-29 |
HUE055305T2 (hu) | 2021-11-29 |
AU2018371966B2 (en) | 2021-02-25 |
HRP20211435T1 (hr) | 2022-01-07 |
EP3713939B1 (en) | 2021-07-21 |
RU2020120838A (ru) | 2021-12-24 |
CN111556870A (zh) | 2020-08-18 |
US11633492B2 (en) | 2023-04-25 |
ES2889775T3 (es) | 2022-01-13 |
JP2021504351A (ja) | 2021-02-15 |
KR20200091431A (ko) | 2020-07-30 |
LT3713939T (lt) | 2021-10-25 |
EP3713939A1 (en) | 2020-09-30 |
PL3713939T3 (pl) | 2021-12-13 |
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