EA202090333A1 - Фармацевтические комбинации, содержащие антитело к bst1 и аналог цитидина - Google Patents

Фармацевтические комбинации, содержащие антитело к bst1 и аналог цитидина

Info

Publication number
EA202090333A1
EA202090333A1 EA202090333A EA202090333A EA202090333A1 EA 202090333 A1 EA202090333 A1 EA 202090333A1 EA 202090333 A EA202090333 A EA 202090333A EA 202090333 A EA202090333 A EA 202090333A EA 202090333 A1 EA202090333 A1 EA 202090333A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bst1
cytidine
analogue
pharmaceutical combinations
combinations containing
Prior art date
Application number
EA202090333A
Other languages
English (en)
Russian (ru)
Inventor
Чечилия Симонелли
Андреа Пеллакани
Моника Бинаски
Даниэла Беллароза
Коррадо Карризи
Original Assignee
Берлин-Хеми Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берлин-Хеми Аг filed Critical Берлин-Хеми Аг
Publication of EA202090333A1 publication Critical patent/EA202090333A1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EA202090333A 2017-07-21 2018-07-20 Фармацевтические комбинации, содержащие антитело к bst1 и аналог цитидина EA202090333A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1711785.4A GB201711785D0 (en) 2017-07-21 2017-07-21 Antibodies
PCT/EP2018/069768 WO2019016371A1 (en) 2017-07-21 2018-07-20 PHARMACEUTICAL ASSOCIATIONS COMPRISING ANTI-BST-1 ANTIBODY AND A CYTIDINE ANALOG

Publications (1)

Publication Number Publication Date
EA202090333A1 true EA202090333A1 (ru) 2020-05-06

Family

ID=59771583

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090333A EA202090333A1 (ru) 2017-07-21 2018-07-20 Фармацевтические комбинации, содержащие антитело к bst1 и аналог цитидина

Country Status (22)

Country Link
US (1) US20200231694A1 (https=)
EP (1) EP3655033A1 (https=)
JP (1) JP2020527594A (https=)
KR (1) KR20200032162A (https=)
CN (1) CN111132697A (https=)
AR (1) AR112460A1 (https=)
AU (1) AU2018303241A1 (https=)
BR (1) BR112020001320A2 (https=)
CA (1) CA3070264A1 (https=)
CL (1) CL2020000175A1 (https=)
CO (1) CO2020001792A2 (https=)
EA (1) EA202090333A1 (https=)
GB (1) GB201711785D0 (https=)
IL (1) IL272096A (https=)
MA (1) MA49627A (https=)
MX (1) MX2020000752A (https=)
PH (1) PH12020550024A1 (https=)
SG (1) SG11202000390TA (https=)
TW (1) TW201907952A (https=)
UY (1) UY37815A (https=)
WO (1) WO2019016371A1 (https=)
ZA (1) ZA202000881B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201809746D0 (en) * 2018-06-14 2018-08-01 Berlin Chemie Ag Pharmaceutical combinations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004063494A1 (de) * 2004-12-23 2006-07-13 Tegenero Ag Antikörper
UA114478C2 (uk) * 2011-06-28 2017-06-26 Берлін-Хемі Аг Антитіло, яке специфічно зв'язується з bst1
GB201806084D0 (en) * 2018-04-13 2018-05-30 Berlin Chemie Ag Antibodies
CN114555123B (zh) * 2019-10-18 2024-04-02 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法

Also Published As

Publication number Publication date
GB201711785D0 (en) 2017-09-06
SG11202000390TA (en) 2020-02-27
ZA202000881B (en) 2021-08-25
BR112020001320A2 (pt) 2020-08-11
MX2020000752A (es) 2020-08-17
AR112460A1 (es) 2019-10-30
IL272096A (en) 2020-03-31
WO2019016371A1 (en) 2019-01-24
CL2020000175A1 (es) 2020-06-12
TW201907952A (zh) 2019-03-01
CN111132697A (zh) 2020-05-08
EP3655033A1 (en) 2020-05-27
AU2018303241A1 (en) 2020-02-20
UY37815A (es) 2019-02-28
CO2020001792A2 (es) 2020-07-31
CA3070264A1 (en) 2019-01-24
MA49627A (fr) 2020-05-27
US20200231694A1 (en) 2020-07-23
PH12020550024A1 (en) 2021-02-15
KR20200032162A (ko) 2020-03-25
JP2020527594A (ja) 2020-09-10

Similar Documents

Publication Publication Date Title
SA520420801B1 (ar) أil جسام مضادة لـ -11
EA202092410A1 (ru) Конъюгаты камптотецина с пептидом
EA201990019A1 (ru) Соединения и композиции для подавления активности shp2
BR112022003956A2 (pt) Anticorpos anti-cd73
JOP20210323A1 (ar) ارتباط أجسام مضادة ثقيلة السلسلة ومتعددة النوعية بـ cd22 وcd3
EA201891988A1 (ru) Ингибиторы mcl-1 на основе замещенных индолов
MX2022004937A (es) Inhibidores de las cinasas raf.
PH12019502576A1 (en) Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
EA201792583A1 (ru) Способы и композиции для ингибирования взаимодействия менина с белками mll
SA518400356B1 (ar) مثبطات الأرجيناز واستخداماتها العلاجية
JOP20200157A1 (ar) أجسام مضادة ذات سلسلة ثقيلة ترتبط بـ cd22
ZA202103867B (en) Tubulysins and protein-tubulysin conjugates
EA201992516A1 (ru) Способ получения бифункциональных белков и их производных
MX2020011100A (es) Compuestos, composiciones farmaceuticas y metodos de uso de agonistas de ppar.
CY1123231T1 (el) Ενωσεις τετραϋδροπυριμιδοδιαζεπινης και τετραϋδροπυριδοδιαζεπινης για θεραπεια πονου και καταστασεων σχετικων με τον πονο
EA202091577A1 (ru) Глюкуронилирование в качестве новой кислотной посттрансляционной модификации терапевтических моноклональных антител
EA202091112A1 (ru) Сокристаллы, фармацевтические композиции на их основе и способы лечения, предусматривающие их применение
EA201891342A1 (ru) Изоиндольные соединения
EA202190807A1 (ru) Антитела к синуклеину
EA202192488A1 (ru) Антитела против tsg-6 и их применения
EA202092540A1 (ru) Комбинации для лечения рака
JOP20220068A1 (ar) بروتينات اندماج nkg2d واستخداماتها
EA202090333A1 (ru) Фармацевтические комбинации, содержащие антитело к bst1 и аналог цитидина
SA521421375B1 (ar) عمليات بديلة لتحضير مركبات تيوبولايسن ومركبات وسيطة منها
EA202191758A1 (ru) Пептиды для лечения и профилактики диабета и связанных с ним заболеваний