EA201991452A1 - Конформное покрытие биологических поверхностей - Google Patents
Конформное покрытие биологических поверхностейInfo
- Publication number
- EA201991452A1 EA201991452A1 EA201991452A EA201991452A EA201991452A1 EA 201991452 A1 EA201991452 A1 EA 201991452A1 EA 201991452 A EA201991452 A EA 201991452A EA 201991452 A EA201991452 A EA 201991452A EA 201991452 A1 EA201991452 A1 EA 201991452A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- biological surfaces
- conformal coating
- organs
- click
- tissues
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Urology & Nephrology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Abstract
Изобретение предусматривает, среди прочего, биологические поверхности с ультратонким конформным покрытием, такие как живые клетки, кластеры клеток, ткани, органы и гибридные синтетические органы, и способы их получения, например, с использованием клик-реакционноспособных водорастворимых полимеров в условиях, которые не повреждают или существенно не модифицируют биологические поверхности. В некоторых вариантах реализации покрытые биологические поверхности являются пригодными для доставки нуждающемуся в этом субъекту.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662433449P | 2016-12-13 | 2016-12-13 | |
PCT/US2017/066072 WO2018112026A1 (en) | 2016-12-13 | 2017-12-13 | Conformal coating of biological surfaces |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201991452A1 true EA201991452A1 (ru) | 2020-01-16 |
Family
ID=60991532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201991452A EA201991452A1 (ru) | 2016-12-13 | 2017-12-13 | Конформное покрытие биологических поверхностей |
Country Status (11)
Country | Link |
---|---|
US (2) | US20190365955A1 (ru) |
EP (1) | EP3554569A1 (ru) |
JP (2) | JP7125398B2 (ru) |
KR (1) | KR20190097055A (ru) |
CN (2) | CN115463261A (ru) |
AU (1) | AU2017378248A1 (ru) |
CA (1) | CA3044892A1 (ru) |
EA (1) | EA201991452A1 (ru) |
IL (1) | IL267005B (ru) |
MX (1) | MX2019006536A (ru) |
WO (1) | WO2018112026A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11655343B2 (en) | 2016-03-24 | 2023-05-23 | Takeda Pharmaceutical Company Limited | Alginate hydrogel compositions |
JP2020524483A (ja) | 2017-05-25 | 2020-08-20 | プレリス バイオロジクス,インク. | 三次元印刷された器官、デバイス、およびマトリックス |
AU2018285539A1 (en) | 2017-06-14 | 2020-02-06 | Vertex Pharmaceuticals Incorporated | Devices and methods for delivering therapeutics |
CN113365674B (zh) * | 2019-02-27 | 2023-02-17 | 泰尔茂株式会社 | 医疗用具的制造方法及医疗用具 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9506844D0 (en) * | 1995-04-03 | 1995-05-24 | Armitage Ian M | Pharmaceutical microencapsulation |
EP1553893A4 (en) * | 2002-10-11 | 2010-09-22 | Novocell Inc | IMPLANTATION OF CAPTURED BIOLOGICAL MATERIAL FOR THE TREATMENT OF DISEASES |
US7824672B2 (en) | 2004-03-26 | 2010-11-02 | Emory University | Method for coating living cells |
US7674452B2 (en) | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
US20090220607A1 (en) * | 2005-09-15 | 2009-09-03 | Kiser Patrick F | Polymeric compositions and methods of making and using thereof |
EP2344131A1 (en) * | 2008-09-16 | 2011-07-20 | Envision Technologies, Inc. | Decomposable biocompatible hydrogels and system and method for using same |
CN102239248B (zh) * | 2008-12-02 | 2013-10-30 | 皇家飞利浦电子股份有限公司 | 同轴封装的细胞悬浮液和微组织 |
WO2010099818A1 (en) * | 2009-03-03 | 2010-09-10 | Ao Technology Ag | Thermoreversible polysaccharide hydrogel |
WO2012149496A1 (en) * | 2011-04-29 | 2012-11-01 | Converge Biotech Inc. | Conformal coating of cells for immunoisolation |
EP2879716B1 (en) * | 2012-07-31 | 2017-05-17 | The University of Akron | Strain-promoted crosslinking of peg-based hydrogels via copper-free cycloaddition |
JP6270158B2 (ja) * | 2012-08-31 | 2018-01-31 | 国立大学法人北陸先端科学技術大学院大学 | 凍結保存可能な細胞足場材料 |
ES2455441B1 (es) * | 2012-09-14 | 2015-02-05 | Universidad De Valladolid | Hidrogel útil como soporte inyectable para aplicación en terapia celular y como sistema de liberación controlada de fármacos |
CN104292454B (zh) * | 2013-07-17 | 2017-12-01 | 北京键凯科技股份有限公司 | 聚乙二醇‑环辛炔衍生物 |
US9381217B2 (en) | 2013-09-09 | 2016-07-05 | Georgia Tech Research Corporation | Microgels for encapsulation of cells and other biologic agents |
US20170182220A1 (en) * | 2014-02-26 | 2017-06-29 | University Of Massachusetts | Degradable hydrogel with predictable tuning of properties, and compositions and methods thereof |
CN104530441B (zh) * | 2015-01-19 | 2017-08-25 | 中山大学 | 一种用于基因和抗肿瘤药物共传递的直链淀粉改性物及其制备方法与应用 |
US10774186B2 (en) * | 2015-04-03 | 2020-09-15 | National Institute Of Advanced Industrial Science And Technology | Photodegradable hydrogel, culture device, method for forming tissue, and method for separating cells |
CA2992692C (en) * | 2015-09-09 | 2021-12-21 | Eth Zurich | Injectable macroporous hydrogels |
-
2017
- 2017-12-13 CN CN202210785817.9A patent/CN115463261A/zh active Pending
- 2017-12-13 EP EP17829779.2A patent/EP3554569A1/en active Pending
- 2017-12-13 MX MX2019006536A patent/MX2019006536A/es unknown
- 2017-12-13 CA CA3044892A patent/CA3044892A1/en not_active Abandoned
- 2017-12-13 JP JP2019529193A patent/JP7125398B2/ja active Active
- 2017-12-13 AU AU2017378248A patent/AU2017378248A1/en not_active Abandoned
- 2017-12-13 KR KR1020197017864A patent/KR20190097055A/ko active Search and Examination
- 2017-12-13 CN CN201780076468.0A patent/CN110049789B/zh active Active
- 2017-12-13 WO PCT/US2017/066072 patent/WO2018112026A1/en unknown
- 2017-12-13 EA EA201991452A patent/EA201991452A1/ru unknown
- 2017-12-13 US US16/467,524 patent/US20190365955A1/en active Pending
-
2019
- 2019-05-30 IL IL267005A patent/IL267005B/en unknown
-
2021
- 2021-12-07 JP JP2021198373A patent/JP2022022330A/ja active Pending
-
2023
- 2023-07-19 US US18/355,360 patent/US20240091414A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN115463261A (zh) | 2022-12-13 |
KR20190097055A (ko) | 2019-08-20 |
US20190365955A1 (en) | 2019-12-05 |
CA3044892A1 (en) | 2018-06-21 |
CN110049789B (zh) | 2022-07-19 |
IL267005A (en) | 2019-07-31 |
WO2018112026A1 (en) | 2018-06-21 |
AU2017378248A1 (en) | 2019-07-04 |
IL267005B (en) | 2021-12-01 |
CN110049789A (zh) | 2019-07-23 |
JP7125398B2 (ja) | 2022-08-24 |
JP2020501646A (ja) | 2020-01-23 |
MX2019006536A (es) | 2019-08-22 |
US20240091414A1 (en) | 2024-03-21 |
JP2022022330A (ja) | 2022-02-03 |
EP3554569A1 (en) | 2019-10-23 |
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